Assessment of the tableting characteristics of a novel sorbitol and calcium diphosphate composites

ABSTRACT: Objective: To improve the tableting properties of sorbitol (SOR) via particle engineering through agglomeration with anhydrous calcium diphosphate (ACD) employing a house-made agglomerator. Methods: A novel SOR: ACD composites were produced by agglomeration at the 95:5; 80:20, 50:50, 20:80 and 6:94 SOR to ACD. The resulting tableting properties such as densification, compressibility, compactibility, ejection force, elastic recovery, sensitivity to lubricants, compression speed and disintegration time were then evaluated. Results: The new agglomerated excipient had better flow, compressibility and compactibility than the physical mixture of SOR and ACD being the 95:5 SOR: ACD ratio the composite that exhibited the best tableting properties. Conclusion: This novel excipient has a potential use as a pharmaceutical aid for direct compression applications.

• Autores: Rojas Camargo, John Jairo; Echeverri Pineda, Edward; Yepes, Marcel
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2015
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/35701
• Acceso en línea: https://hdl.handle.net/10495/35701; https://innovareacademics.in/journals/index.php/ijpps
• Palabra clave: Sorbitol; Pirofosfato de Calcio; Calcium Pyrophosphate; Excipientes; Excipients; Preparaciones Farmacéuticas; Pharmaceutical Preparations
• Rights: openAccess
• License: https://creativecommons.org/licenses/by/4.0/