Anthropometry, body shape in early-life and risk of premenopausal breast cancer among Latin American women results from the PRECAMA study

ABSTRACT: Cumulating evidence in Caucasian women suggests a positive association between height and premenopausal breast cancer risk and a negative association with overall adiposity; however data from Latin America are scarce. We investigated the associations between excess adiposity, body shape evolution across life, and risk of premenopausal breast cancer among 406 cases (women aged 20-45) and 406 matched population-based controls from Chile, Colombia, Costa Rica, and Mexico. Negative associations between adult adiposity and breast cancer risk were observed in adjusted models (body mass index (BMI): Odds ratio (OR) per 1 kg/m2 = 0.93; 95% confidence interval = 0.89-0.96; waist circumference (WC): OR per 10 cm = 0.81 (0.69-0.96); hip circumference (HC): OR per 10 cm = 0.80 (0.67-0.95)). Height and leg length were not associated with risk. In normal weight women (18.5 ≤ BMI < 25), women with central obesity (WC > 88 cm) had an increased risk compared to women with normal WC (OR = 3.60(1.47-8.79)). Residuals of WC over BMI showed positive associations when adjusted for BMI (OR per 10 cm = 1.38 (0.98-1.94)). Body shape at younger ages and body shape evolution were not associated with risk. No heterogeneity was observed by receptor status. In this population of Latin American premenopausal women, different fat distributions in adulthood were differentially associated with risk of breast cancer.

• Autores: Bedoya Berrío, Gabriel de Jesús; Sánchez Vásquez, Gloria; Borrero Franco, Mauricio; Torres Mejía, Gabriela; Ángeles Llerenas, Angélica; Alvarado Cabrero, Isabel; His, Mathilde; Biessy, Carine; Porras, Carolina; Rodríguez, Ana Cecilia; Garmendia, Maria Luisa; Olivier, Magali; Porter, Peggy L; Lin, MingGang; Gunter, Marc J; Romieu, Isabelle; Rinaldi, Sabina; Tejeda, Jenny; Navarro, Edgar; Jaramillo, Roberto; Rodas Cortes, Yorlany; Ángel, Alberto; Andres Ossa, Carlos; Arias, William H; Cock Rada, Alicia María; Echeverri, Carolina; Herazo, Fernando; Díaz Yunez, Israel; Hernández, Ángel; Cortes, Bernal; González, Paula; Ocampo, Rebecca; Guillen, Diego; Moyano, Leonor; Soto, José Luis; Donato, Elizabeth; Guenthoer, Jamie; Donn, Thomas; Wirtala, Kelly; Loucks, Hailey
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2020
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/41110
• Acceso en línea: https://hdl.handle.net/10495/41110
• Palabra clave: Adiposity; Adiposidad; Body Mass Index; Índice de Masa Corporal; Breast Neoplasms; Neoplasias de la Mama; Case-Control Studies; Estudios de Casos y Controles; Obesity, Abdominal; Obesidad Abdominal; Premenopause; Premenopausia; Risk Factors; Factores de Riesgo; Waist Circumference; Circunferencia de la Cintura; https://id.nlm.nih.gov/mesh/D050154; https://id.nlm.nih.gov/mesh/D015992; https://id.nlm.nih.gov/mesh/D001943; https://id.nlm.nih.gov/mesh/D016022; https://id.nlm.nih.gov/mesh/D056128; https://id.nlm.nih.gov/mesh/D017697; https://id.nlm.nih.gov/mesh/D012307; https://id.nlm.nih.gov/mesh/D055105
• Rights: openAccess
• License: http://creativecommons.org/licenses/by/2.5/co/