Selective interaction of lansoprazole and astemizole with tau polymers: potential new clinical use in diagnosis of Alzheimer's disease

ABSTRACT: We describe the interactions of two benzimidazole derivatives, astemizole (AST) and lansoprazole (LNS), with anomalous aggregates of tau protein (neurofibrillary tangles). Interestingly, these compounds, with important medical applications in the treatment of allergies and gastrointestinal...

Full description

Autores:

Alzate Morales, Jans Humberto
Rojo, Leonel E.
Saavedra, Iván N.
Davies, Peter
Maccioni, Ricardo B.

Tipo de recurso:

Article of investigation

Fecha de publicación:

2010

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/35961

Acceso en línea:

https://hdl.handle.net/10495/35961

Palabra clave:

Enfermedad de Alzheimer
Alzheimer Disease
Astemizol - química
Astemizole - chemistry
Cromatografía Líquida de Alta Presión
Chromatography, High Pressure Liquid
Biología Computacional
Computational Biology
Relación Dosis-Respuesta a Droga
Dose-Response Relationship, Drug
Técnicas Electroquímicas
Electrochemical Techniques
Tomografía con Microscopio Electrónico - métodos
Electron Microscope Tomography - methods
Inhibidores Enzimáticos - química
Enzyme Inhibitors - chemistry
Lansoprazol
Lansoprazole
Modelos Moleculares
Models, Molecular
Ovillos Neurofibrilares
Neurofibrillary Tangles
Resonancia por Plasmón de Superficie
Surface Plasmon Resonance

Rights

openAccess

License

https://creativecommons.org/licenses/by-nc/4.0/