Serological Markers and Risk Factors for Hepatitis B and C Viruses in Patients Infected with Human Immunodeficiency Virus
ABSTRACT: Both hepatitis B and hepatitis C viruses (HBV and HCV) infection are common in HIV-infected individuals as a result of shared risk factors for acquisition. A serological studyfor HBV and HCV was performed in 251 HIV-positive individuals from Medellín, Colombia. A qualitative RT-PCR for HCV...
- Autores:
-
Hoyos Orrego, Álvaro Darío
Massaro Ceballos, Mónica
Ospina Ospina, Marta
Gómez Builes, Carolina
Vanegas Arroyave, Nora
Tobón Pereira, Juan
Jaramillo Hurtado, Javier
Rugeles López, María Teresa
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2006
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/35031
- Acceso en línea:
- https://hdl.handle.net/10495/35031
- Palabra clave:
- Hepatitis B virus
Virus de la Hepatitis B
Hepacivirus
HIV
VIH
Risk Factors
Factores de Riesgo
Hepatitis C
Biomarkers
Biomarcadores
Diagnosis
Diagnóstico
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc/2.5/co/
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| dc.title.spa.fl_str_mv |
Serological Markers and Risk Factors for Hepatitis B and C Viruses in Patients Infected with Human Immunodeficiency Virus |
| dc.title.translated.spa.fl_str_mv |
Marcadores serológicos y factores de riesgo para los virus de la hepatitis B y C en individuos infectados por el VIH |
| title |
Serological Markers and Risk Factors for Hepatitis B and C Viruses in Patients Infected with Human Immunodeficiency Virus |
| spellingShingle |
Serological Markers and Risk Factors for Hepatitis B and C Viruses in Patients Infected with Human Immunodeficiency Virus Hepatitis B virus Virus de la Hepatitis B Hepacivirus HIV VIH Risk Factors Factores de Riesgo Hepatitis C Biomarkers Biomarcadores Diagnosis Diagnóstico |
| title_short |
Serological Markers and Risk Factors for Hepatitis B and C Viruses in Patients Infected with Human Immunodeficiency Virus |
| title_full |
Serological Markers and Risk Factors for Hepatitis B and C Viruses in Patients Infected with Human Immunodeficiency Virus |
| title_fullStr |
Serological Markers and Risk Factors for Hepatitis B and C Viruses in Patients Infected with Human Immunodeficiency Virus |
| title_full_unstemmed |
Serological Markers and Risk Factors for Hepatitis B and C Viruses in Patients Infected with Human Immunodeficiency Virus |
| title_sort |
Serological Markers and Risk Factors for Hepatitis B and C Viruses in Patients Infected with Human Immunodeficiency Virus |
| dc.creator.fl_str_mv |
Hoyos Orrego, Álvaro Darío Massaro Ceballos, Mónica Ospina Ospina, Marta Gómez Builes, Carolina Vanegas Arroyave, Nora Tobón Pereira, Juan Jaramillo Hurtado, Javier Rugeles López, María Teresa |
| dc.contributor.author.none.fl_str_mv |
Hoyos Orrego, Álvaro Darío Massaro Ceballos, Mónica Ospina Ospina, Marta Gómez Builes, Carolina Vanegas Arroyave, Nora Tobón Pereira, Juan Jaramillo Hurtado, Javier Rugeles López, María Teresa |
| dc.contributor.researchgroup.spa.fl_str_mv |
Inmunovirología |
| dc.subject.decs.none.fl_str_mv |
Hepatitis B virus Virus de la Hepatitis B Hepacivirus HIV VIH Risk Factors Factores de Riesgo Hepatitis C Biomarkers Biomarcadores Diagnosis Diagnóstico |
| topic |
Hepatitis B virus Virus de la Hepatitis B Hepacivirus HIV VIH Risk Factors Factores de Riesgo Hepatitis C Biomarkers Biomarcadores Diagnosis Diagnóstico |
| description |
ABSTRACT: Both hepatitis B and hepatitis C viruses (HBV and HCV) infection are common in HIV-infected individuals as a result of shared risk factors for acquisition. A serological studyfor HBV and HCV was performed in 251 HIV-positive individuals from Medellín, Colombia. A qualitative RT-PCR for HCV was done in 90 patients with CD4+ T-cell count < 150 per mm³. Serological markers for HBV infection were present in 97 (38.6%) patients. Thirty six of them (37.1%) had isolated anti-HBc. A multivariate analysis indicated that the following risk factors were significantly associated with the presence of these markers: age (OR = 1.05, 95% CI: 1.01-1.08), pediculosis pubis (OR = 1.83, 95% CI: 1.01-3.33), men who have sex with men and women (OR = 3.23, 95% CI: 1.46-7.13) and men who have sex only with men (OR = 3.73, 95% CI: 1.58-8.78). The same analysis restricted to women showed syphilis as the only significant risk factor. Thus, HBV infection was considerably associated with high risk sexual behavior. HCV was present in only two (0.8%) of HIV patients. Both of them were positive by RT-PCR and anti-HCV. This low frequency of HIV/HCV coinfection was probably due to the uncommon intravenous drug abuse in this population. The frequent finding of isolated anti-HBc warrants molecular approaches to rule out the presence of cryptic HBV infection. |
| publishDate |
2006 |
| dc.date.issued.none.fl_str_mv |
2006 |
| dc.date.accessioned.none.fl_str_mv |
2023-05-16T17:16:59Z |
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2023-05-16T17:16:59Z |
| dc.type.spa.fl_str_mv |
Artículo de investigación |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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0036-4665 |
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https://hdl.handle.net/10495/35031 |
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1678-9946 |
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0036-4665 1678-9946 |
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https://hdl.handle.net/10495/35031 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Rev. Inst. Med. Trop. São Paulo. |
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326 |
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6 |
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321 |
| dc.relation.citationvolume.spa.fl_str_mv |
48 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Revista do Instituto de Medicina Tropical de Sao Paulo |
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http://creativecommons.org/licenses/by-nc/2.5/co/ |
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Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo |
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São Paulo, Brasil |
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sin facultad - programa |
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Universidad de Antioquia |
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Hoyos Orrego, Álvaro DaríoMassaro Ceballos, MónicaOspina Ospina, MartaGómez Builes, CarolinaVanegas Arroyave, NoraTobón Pereira, JuanJaramillo Hurtado, JavierRugeles López, María TeresaInmunovirología2023-05-16T17:16:59Z2023-05-16T17:16:59Z20060036-4665https://hdl.handle.net/10495/350311678-9946ABSTRACT: Both hepatitis B and hepatitis C viruses (HBV and HCV) infection are common in HIV-infected individuals as a result of shared risk factors for acquisition. A serological studyfor HBV and HCV was performed in 251 HIV-positive individuals from Medellín, Colombia. A qualitative RT-PCR for HCV was done in 90 patients with CD4+ T-cell count < 150 per mm³. Serological markers for HBV infection were present in 97 (38.6%) patients. Thirty six of them (37.1%) had isolated anti-HBc. A multivariate analysis indicated that the following risk factors were significantly associated with the presence of these markers: age (OR = 1.05, 95% CI: 1.01-1.08), pediculosis pubis (OR = 1.83, 95% CI: 1.01-3.33), men who have sex with men and women (OR = 3.23, 95% CI: 1.46-7.13) and men who have sex only with men (OR = 3.73, 95% CI: 1.58-8.78). The same analysis restricted to women showed syphilis as the only significant risk factor. Thus, HBV infection was considerably associated with high risk sexual behavior. HCV was present in only two (0.8%) of HIV patients. Both of them were positive by RT-PCR and anti-HCV. This low frequency of HIV/HCV coinfection was probably due to the uncommon intravenous drug abuse in this population. The frequent finding of isolated anti-HBc warrants molecular approaches to rule out the presence of cryptic HBV infection.ABSTRACT: Both hepatitis B and hepatitis C viruses (HBV and HCV) infection are common in HIV-infected individuals as a result of shared risk factors for acquisition. A serological studyfor HBV and HCV was performed in 251 HIV-positive individuals from Medellín, Colombia. A qualitative RT-PCR for HCV was done in 90 patients with CD4+ T-cell count < 150 per mm³. Serological markers for HBV infection were present in 97 (38.6%) patients. Thirty six of them (37.1%) had isolated anti-HBc. A multivariate analysis indicated that the following risk factors were significantly associated with the presence of these markers: age (OR = 1.05, 95% CI: 1.01-1.08), pediculosis pubis (OR = 1.83, 95% CI: 1.01-3.33), men who have sex with men and women (OR = 3.23, 95% CI: 1.46-7.13) and men who have sex only with men (OR = 3.73, 95% CI: 1.58-8.78). The same analysis restricted to women showed syphilis as the only significant risk factor. Thus, HBV infection was considerably associated with high risk sexual behavior. HCV was present in only two (0.8%) of HIV patients. Both of them were positive by RT-PCR and anti-HCV. This low frequency of HIV/HCV coinfection was probably due to the uncommon intravenous drug abuse in this population. The frequent finding of isolated anti-HBc warrants molecular approaches to rule out the presence of cryptic HBV infection.RESUMEN: La infección por los virus de la hepatitis B y hepatitis C (VHB y VHC) es frecuente en individuos infectados por el VIH como resultado de compartir factores de riesgo para su contagio. Se realizó un estudio serológico para el VHB y VHC en 251 individuos VIH positivos de la ciudad de Medellín, Colombia. En 90 pacientes con un recuento de linfocitos T < 150 células por mm³ se hizo una PCR-RT cualitativa para el VHC. Se encontraron marcadores serológicos para la infección por el VHB en 97 (38.6%) pacientes. Treinta y seis de 97 (37.1%) tuvieron un anti-HBc aislado. El análisis multivariado indicó que los factores de riesgo significativos asociados a la presencia de estos marcadores fueron: edad (OR = 1.05, 95% IC: 1.01-1.08), pediculosis púbica (OR = 1.83, 95% IC: 1.01-3.33), hombres que tienen sexo con hombres y mujeres (OR = 3.23, 95% IC: 1.46-7.13) y hombres que tienen sexo solo con hombres (OR = 3.73, 95% IC: 1.58-8.78). El mismo análisis restringido a mujeres mostró que la sífilis fue el único factor de riesgo significativo. Por lo tanto, la infección por el VHB fue considerablemente asociada a conductas sexuales de alto riesgo. El VHC se presentó en solo 2 (0.8%) de los pacientes VIH. Ambos pacientes fueron positivos por la PCR-RT y los anti-VHC. La baja frecuencia de la coinfección VIH/VHC fue probablemente debido al bajo uso de drogas intravenosas en esta población. El hallazgo frecuente de anti-HBc como marcador aislado asegura estudios moleculares para descartar la presencia de infección críptica por el VHB.RESUMEN: La infección por los virus de la hepatitis B y hepatitis C (VHB y VHC) es frecuente en individuos infectados por el VIH como resultado de compartir factores de riesgo para su contagio. Se realizó un estudio serológico para el VHB y VHC en 251 individuos VIH positivos de la ciudad de Medellín, Colombia. En 90 pacientes con un recuento de linfocitos T < 150 células por mm³ se hizo una PCR-RT cualitativa para el VHC. Se encontraron marcadores serológicos para la infección por el VHB en 97 (38.6%) pacientes. Treinta y seis de 97 (37.1%) tuvieron un anti-HBc aislado. El análisis multivariado indicó que los factores de riesgo significativos asociados a la presencia de estos marcadores fueron: edad (OR = 1.05, 95% IC: 1.01-1.08), pediculosis púbica (OR = 1.83, 95% IC: 1.01-3.33), hombres que tienen sexo con hombres y mujeres (OR = 3.23, 95% IC: 1.46-7.13) y hombres que tienen sexo solo con hombres (OR = 3.73, 95% IC: 1.58-8.78). El mismo análisis restringido a mujeres mostró que la sífilis fue el único factor de riesgo significativo. Por lo tanto, la infección por el VHB fue considerablemente asociada a conductas sexuales de alto riesgo. El VHC se presentó en solo 2 (0.8%) de los pacientes VIH. Ambos pacientes fueron positivos por la PCR-RT y los anti-VHC. La baja frecuencia de la coinfección VIH/VHC fue probablemente debido al bajo uso de drogas intravenosas en esta población. El hallazgo frecuente de anti-HBc como marcador aislado asegura estudios moleculares para descartar la presencia de infección críptica por el VHB.COL00124446application/pdfengUniversidade de São Paulo, Instituto de Medicina Tropical de São PauloSão Paulo, Brasilsin facultad - programahttp://creativecommons.org/licenses/by-nc/2.5/co/https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Serological Markers and Risk Factors for Hepatitis B and C Viruses in Patients Infected with Human Immunodeficiency VirusMarcadores serológicos y factores de riesgo para los virus de la hepatitis B y C en individuos infectados por el VIHArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionHepatitis B virusVirus de la Hepatitis BHepacivirusHIVVIHRisk FactorsFactores de RiesgoHepatitis CBiomarkersBiomarcadoresDiagnosisDiagnósticoRev. Inst. Med. Trop. 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