Serological Markers and Risk Factors for Hepatitis B and C Viruses in Patients Infected with Human Immunodeficiency Virus

ABSTRACT: Both hepatitis B and hepatitis C viruses (HBV and HCV) infection are common in HIV-infected individuals as a result of shared risk factors for acquisition. A serological studyfor HBV and HCV was performed in 251 HIV-positive individuals from Medellín, Colombia. A qualitative RT-PCR for HCV was done in 90 patients with CD4+ T-cell count < 150 per mm³. Serological markers for HBV infection were present in 97 (38.6%) patients. Thirty six of them (37.1%) had isolated anti-HBc. A multivariate analysis indicated that the following risk factors were significantly associated with the presence of these markers: age (OR = 1.05, 95% CI: 1.01-1.08), pediculosis pubis (OR = 1.83, 95% CI: 1.01-3.33), men who have sex with men and women (OR = 3.23, 95% CI: 1.46-7.13) and men who have sex only with men (OR = 3.73, 95% CI: 1.58-8.78). The same analysis restricted to women showed syphilis as the only significant risk factor. Thus, HBV infection was considerably associated with high risk sexual behavior. HCV was present in only two (0.8%) of HIV patients. Both of them were positive by RT-PCR and anti-HCV. This low frequency of HIV/HCV coinfection was probably due to the uncommon intravenous drug abuse in this population. The frequent finding of isolated anti-HBc warrants molecular approaches to rule out the presence of cryptic HBV infection.

• Autores: Hoyos Orrego, Álvaro Darío; Massaro Ceballos, Mónica; Ospina Ospina, Marta; Gómez Builes, Carolina; Vanegas Arroyave, Nora; Tobón Pereira, Juan; Jaramillo Hurtado, Javier; Rugeles López, María Teresa
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2006
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/35031
• Acceso en línea: https://hdl.handle.net/10495/35031
• Palabra clave: Hepatitis B virus; Virus de la Hepatitis B; Hepacivirus; HIV; VIH; Risk Factors; Factores de Riesgo; Hepatitis C; Biomarkers; Biomarcadores; Diagnosis; Diagnóstico
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc/2.5/co/