Effects of Cathepsin S Inhibition in the Age-Related Dry Eye Phenotype

ABSTRACT: Purpose: Aged C57BL/6J (B6) mice have increased levels of cathepsin S, and aged cathepsin S (Ctss-/-) knockout mice are resistant to age-related dry eye. This study investigated the effects of cathepsin S inhibition on age-related dry eye disease. Methods: Female B6 mice aged 15.5 to 17 mo...

Full description

Autores:

Trujillo Vargas, Claudia Milena
Galletti, Jeremias G.
Scholand, Kaitlin K.
Haap, Wolfgang
Santos Ferreira, Tiago
Ullmer, Christoph
Yu, Zhiyuan
de Paiva, Cintia S.

Tipo de recurso:

Article of investigation

Fecha de publicación:

2023

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/39048

Acceso en línea:

https://hdl.handle.net/10495/39048

Palabra clave:

Modelos Animales de Enfermedad
Disease Models, Animal
Síndromes de Ojo Seco
Dry Eye Syndromes
Enfermedades del Aparato Lagrimal
Lacrimal Apparatus Diseases
Ratones Endogámicos C57BL
Mice, Inbred C57BL
Alcohol Polivinílico
Polyvinyl Alcohol
Lagrimas - metabolismo
Tears - metabolism
https://id.nlm.nih.gov/mesh/D015352
https://id.nlm.nih.gov/mesh/D008810
https://id.nlm.nih.gov/mesh/D004195
https://id.nlm.nih.gov/mesh/D007766
https://id.nlm.nih.gov/mesh/D011142
https://id.nlm.nih.gov/mesh/D013666

Rights

openAccess

License

https://creativecommons.org/licenses/by-nc-nd/4.0/