Papel de la leptina y su receptor en la glándula mamaria bovina
ABSTRACT: Leptin is a hormone-like protein involved in physiological processes related to the regulation of energy metabolism, reproduction, immunity, cancer, breastfeeding, among others. Leptin receptor is expressed in almost all tissues and generates six isoforms from a single mRNA. The predominan...
- Autores:
-
Echeverry Berrío, Diana María
Penagos Tabares, Felipe
Ruiz Cortés, Zulma Tatiana
- Tipo de recurso:
- Review article
- Fecha de publicación:
- 2012
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- spa
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/9000
- Acceso en línea:
- http://hdl.handle.net/10495/9000
- Palabra clave:
- Bovinos
Lactancia (animales)
Rumiantes
Bovine
Ruminants
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-sa/4.0/
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Papel de la leptina y su receptor en la glándula mamaria bovina |
| dc.title.translated.spa.fl_str_mv |
Role of leptin and its receptor on bovine mammary gland |
| title |
Papel de la leptina y su receptor en la glándula mamaria bovina |
| spellingShingle |
Papel de la leptina y su receptor en la glándula mamaria bovina Bovinos Lactancia (animales) Rumiantes Bovine Ruminants |
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Papel de la leptina y su receptor en la glándula mamaria bovina |
| title_full |
Papel de la leptina y su receptor en la glándula mamaria bovina |
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Papel de la leptina y su receptor en la glándula mamaria bovina |
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Papel de la leptina y su receptor en la glándula mamaria bovina |
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Papel de la leptina y su receptor en la glándula mamaria bovina |
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Echeverry Berrío, Diana María Penagos Tabares, Felipe Ruiz Cortés, Zulma Tatiana |
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Echeverry Berrío, Diana María Penagos Tabares, Felipe Ruiz Cortés, Zulma Tatiana |
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Biogénesis |
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Bovinos Lactancia (animales) Rumiantes Bovine Ruminants |
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Bovinos Lactancia (animales) Rumiantes Bovine Ruminants |
| description |
ABSTRACT: Leptin is a hormone-like protein involved in physiological processes related to the regulation of energy metabolism, reproduction, immunity, cancer, breastfeeding, among others. Leptin receptor is expressed in almost all tissues and generates six isoforms from a single mRNA. The predominant isoform in bovine mammary gland is the Ob-Rb, which triggers a signaling cascade through JAK-STAT molecules to induce proliferation, differentiation and apoptosis, according to the female reproductive stage. In small ruminants, such as sheep and goats, leptin and its receptor levels vary widely, being high at the beginning of pregnancy, tending to fall in mid-gestation, and remaining low until the end of lactation. An expression pattern of leptin receptor has not yet been established for the various reproductive stages in bovine mammary gland. Such study is considered important and necessary to understand the effect of leptin via its receptor in mammary gland, especially during lactation when the gland undergoes tissue remodeling to sustain high milk production. This review presents a hypothesis about the signaling pathway triggered by leptin receptor in the mammary gland during bovine lactation. |
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2012 |
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2012 |
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2018-02-01T19:58:34Z |
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Echeverry DM, Penagos F, Ruíz-Cortéz ZT. Papel de la leptina y su receptor en la glándula mamaria bovina. Rev Colomb Cienc Pecu. 2012;25(3):500-510. |
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2256-2958 |
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Echeverry DM, Penagos F, Ruíz-Cortéz ZT. Papel de la leptina y su receptor en la glándula mamaria bovina. Rev Colomb Cienc Pecu. 2012;25(3):500-510. 0120-0690 2256-2958 |
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spa |
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Rev. Colomb. Cienc. Pecu. |
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Echeverry Berrío, Diana MaríaPenagos Tabares, FelipeRuiz Cortés, Zulma TatianaBiogénesis2018-02-01T19:58:34Z2018-02-01T19:58:34Z2012Echeverry DM, Penagos F, Ruíz-Cortéz ZT. Papel de la leptina y su receptor en la glándula mamaria bovina. Rev Colomb Cienc Pecu. 2012;25(3):500-510.0120-0690http://hdl.handle.net/10495/90002256-2958ABSTRACT: Leptin is a hormone-like protein involved in physiological processes related to the regulation of energy metabolism, reproduction, immunity, cancer, breastfeeding, among others. Leptin receptor is expressed in almost all tissues and generates six isoforms from a single mRNA. The predominant isoform in bovine mammary gland is the Ob-Rb, which triggers a signaling cascade through JAK-STAT molecules to induce proliferation, differentiation and apoptosis, according to the female reproductive stage. In small ruminants, such as sheep and goats, leptin and its receptor levels vary widely, being high at the beginning of pregnancy, tending to fall in mid-gestation, and remaining low until the end of lactation. An expression pattern of leptin receptor has not yet been established for the various reproductive stages in bovine mammary gland. Such study is considered important and necessary to understand the effect of leptin via its receptor in mammary gland, especially during lactation when the gland undergoes tissue remodeling to sustain high milk production. This review presents a hypothesis about the signaling pathway triggered by leptin receptor in the mammary gland during bovine lactation.RESUMEN: La leptina es una hormona proteínica que participa en procesos fisiológicos relacionados con la regulación del metabolismo energético, reproducción, inmunidad, cáncer, lactancia, entre otros. Su receptor se expresa en casi la totalidad de los tejidos, presentando seis isoformas a partir de un mismo ARNm. La isoforma predominante en la glándula mamaria bovina es la Ob-Rb, a través de la cual se puede desencadenar una cascada de señalización por medio de las moléculas JAK-STAT, para inducir proliferación, diferenciación y apoptosis celular de acuerdo al estadio reproductivo de la hembra. En pequeños rumiantes, tales como ovejas y cabras, los niveles de leptina y su receptor varían considerablemente durante la preñez y lactancia: son altos al inicio de la gestación, tienden a descender hasta la mitad de esta etapa y permanecen bajos hasta la finalización de la lactancia. En la glándula mamaria de bovinos aún no se ha establecido un patrón de expresión de los receptores durante diferentes etapas reproductivas, estudio que se considera importante y necesario para comprender el efecto de la leptina sobre su receptor en glándula mamaria, especialmente durante la lactancia, período durante el cual sufre una remodelación celular del tejido glandular para sostener una alta producción láctea. En la presente revisión se plantea una hipótesis de cómo podría ser la vía de señalización desencadenada por el receptor de leptina en la glándula mamaria durante la lactancia.COL0066561application/pdfspaUniversidad de Antioquia, Facultad de Ciencias AgrariasMedellín, Colombiahttps://creativecommons.org/licenses/by-nc-sa/4.0/https://creativecommons.org/licenses/by-nc-sa/2.5/co/Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2BovinosLactancia (animales)RumiantesBovineRuminantsPapel de la leptina y su receptor en la glándula mamaria bovinaRole of leptin and its receptor on bovine mammary glandArtículo de revisiónhttp://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTREVhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRev. Colomb. Cienc. 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