Leukogram Profile and Clinical Status in vivax and falciparum Malaria Patients from Colombia
ABSTARCT: Hematological alterations are frequent in malaria patients; the relationship between alterations in white blood cell counts and clinical status in malaria is not well understood. In Colombia, with low endemicity and unstable transmission for malaria, with malaria vivax predominance, the he...
- Autores:
-
Tobón Castaño, Alberto
Mesa Echeverry, Esteban
Miranda Arboleda, Andrés Felipe
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2015
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/11422
- Acceso en línea:
- http://hdl.handle.net/10495/11422
- Palabra clave:
- Malaria Falciparum
Malaria Vivax
Recuento de Leucocitos
Leukocyte Count
Malaria, Falciparum
Malaria, Vivax
Malaria
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by/2.5/co/
| id |
UDEA2_78d8e689d7336927bca1cfce7419a439 |
|---|---|
| oai_identifier_str |
oai:bibliotecadigital.udea.edu.co:10495/11422 |
| network_acronym_str |
UDEA2 |
| network_name_str |
Repositorio UdeA |
| repository_id_str |
|
| dc.title.spa.fl_str_mv |
Leukogram Profile and Clinical Status in vivax and falciparum Malaria Patients from Colombia |
| title |
Leukogram Profile and Clinical Status in vivax and falciparum Malaria Patients from Colombia |
| spellingShingle |
Leukogram Profile and Clinical Status in vivax and falciparum Malaria Patients from Colombia Malaria Falciparum Malaria Vivax Recuento de Leucocitos Leukocyte Count Malaria, Falciparum Malaria, Vivax Malaria |
| title_short |
Leukogram Profile and Clinical Status in vivax and falciparum Malaria Patients from Colombia |
| title_full |
Leukogram Profile and Clinical Status in vivax and falciparum Malaria Patients from Colombia |
| title_fullStr |
Leukogram Profile and Clinical Status in vivax and falciparum Malaria Patients from Colombia |
| title_full_unstemmed |
Leukogram Profile and Clinical Status in vivax and falciparum Malaria Patients from Colombia |
| title_sort |
Leukogram Profile and Clinical Status in vivax and falciparum Malaria Patients from Colombia |
| dc.creator.fl_str_mv |
Tobón Castaño, Alberto Mesa Echeverry, Esteban Miranda Arboleda, Andrés Felipe |
| dc.contributor.author.none.fl_str_mv |
Tobón Castaño, Alberto Mesa Echeverry, Esteban Miranda Arboleda, Andrés Felipe |
| dc.contributor.researchgroup.spa.fl_str_mv |
Grupo Malaria |
| dc.subject.none.fl_str_mv |
Malaria Falciparum Malaria Vivax Recuento de Leucocitos Leukocyte Count Malaria, Falciparum Malaria, Vivax Malaria |
| topic |
Malaria Falciparum Malaria Vivax Recuento de Leucocitos Leukocyte Count Malaria, Falciparum Malaria, Vivax Malaria |
| description |
ABSTARCT: Hematological alterations are frequent in malaria patients; the relationship between alterations in white blood cell counts and clinical status in malaria is not well understood. In Colombia, with low endemicity and unstable transmission for malaria, with malaria vivax predominance, the hematologic profile in malaria patients is not well characterized. The aim of this study was to characterize the leukogram in malaria patients and to analyze its alterations in relation to the clinical status. METHODS: 888 leukogram profiles of malaria patients from different Colombian regions were studied: 556 with P. falciparum infection (62.6%), 313 with P. vivax infection (35.2%), and 19 with mixed infection by these species (2.1%). RESULTS: Leukocyte counts at diagnosis were within normal range in 79% of patients and 18% had leucopenia; the most frequent alteration was lymphopenia (54%) followed by monocytosis (11%); the differential granulocyte count in 298 patients revealed eosinophilia (15%) and high basophil counts (8%). Leukocytosis, eosinopenia, and neutrophilia were associated with clinical complications. The utility of changes in leukocyte counts as markers of severity should be explored in depth. A better understanding of these hematological parameters will allow their use in prompt diagnosis of malaria complications and monitoring treatment response. |
| publishDate |
2015 |
| dc.date.issued.none.fl_str_mv |
2015 |
| dc.date.accessioned.none.fl_str_mv |
2019-07-12T19:22:25Z |
| dc.date.available.none.fl_str_mv |
2019-07-12T19:22:25Z |
| dc.type.spa.fl_str_mv |
Artículo de investigación |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/ART |
| dc.type.coarversion.spa.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| status_str |
publishedVersion |
| dc.identifier.citation.spa.fl_str_mv |
Tobón-Castaño A, Mesa-Echeverry E, Miranda-Arboleda AF. Leukogram Profile and Clinical Status in vivax and falciparum Malaria Patients from Colombia. J Trop Med. 2015;2015:796182 |
| dc.identifier.issn.none.fl_str_mv |
1687-9686 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/11422 |
| dc.identifier.doi.none.fl_str_mv |
10.1155/2015/796182 |
| dc.identifier.eissn.none.fl_str_mv |
1687-9694 |
| identifier_str_mv |
Tobón-Castaño A, Mesa-Echeverry E, Miranda-Arboleda AF. Leukogram Profile and Clinical Status in vivax and falciparum Malaria Patients from Colombia. J Trop Med. 2015;2015:796182 1687-9686 10.1155/2015/796182 1687-9694 |
| url |
http://hdl.handle.net/10495/11422 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
J. Trop. Med |
| dc.relation.citationendpage.spa.fl_str_mv |
12 |
| dc.relation.citationstartpage.spa.fl_str_mv |
1 |
| dc.relation.citationvolume.spa.fl_str_mv |
2015 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
ournal of Tropical Medicine |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by/2.5/co/ |
| dc.rights.uri.spa.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
| dc.rights.accessrights.*.fl_str_mv |
Atribución 2.5 |
| dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.coar.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| rights_invalid_str_mv |
http://creativecommons.org/licenses/by/2.5/co/ https://creativecommons.org/licenses/by/4.0/ Atribución 2.5 http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.extent.spa.fl_str_mv |
11 |
| dc.format.mimetype.spa.fl_str_mv |
application/pdf |
| dc.publisher.spa.fl_str_mv |
Hindawi Publishing Corporation |
| dc.publisher.place.spa.fl_str_mv |
Egipto |
| institution |
Universidad de Antioquia |
| bitstream.url.fl_str_mv |
https://bibliotecadigital.udea.edu.co/bitstreams/2126e450-10d8-4646-8f32-e47037b37487/download https://bibliotecadigital.udea.edu.co/bitstreams/7d31632f-19b1-4916-863a-c95889191f64/download https://bibliotecadigital.udea.edu.co/bitstreams/da454a05-8c8e-478b-9aeb-34ccfc43e1e9/download https://bibliotecadigital.udea.edu.co/bitstreams/fe15c602-efcf-468f-bbed-909c4e5a2fa4/download https://bibliotecadigital.udea.edu.co/bitstreams/e1a4e6ec-c853-4954-a141-42f438a545bf/download https://bibliotecadigital.udea.edu.co/bitstreams/dfa2be52-bbe2-4275-9325-277e0a31c129/download https://bibliotecadigital.udea.edu.co/bitstreams/3180ff6d-531b-4388-a12b-7a6a2d519074/download |
| bitstream.checksum.fl_str_mv |
1ab9e1c8df1a0b8b4e34826de150662b 4afdbb8c545fd630ea7db775da747b2f d41d8cd98f00b204e9800998ecf8427e d41d8cd98f00b204e9800998ecf8427e 8a4605be74aa9ea9d79846c1fba20a33 472552db93efe839d635c6ca1bbdb180 a494fda0d343e3e15886136e2d836d7a |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositorio Institucional de la Universidad de Antioquia |
| repository.mail.fl_str_mv |
aplicacionbibliotecadigitalbiblioteca@udea.edu.co |
| _version_ |
1851052147734478848 |
| spelling |
Tobón Castaño, AlbertoMesa Echeverry, EstebanMiranda Arboleda, Andrés FelipeGrupo Malaria2019-07-12T19:22:25Z2019-07-12T19:22:25Z2015Tobón-Castaño A, Mesa-Echeverry E, Miranda-Arboleda AF. Leukogram Profile and Clinical Status in vivax and falciparum Malaria Patients from Colombia. J Trop Med. 2015;2015:7961821687-9686http://hdl.handle.net/10495/1142210.1155/2015/7961821687-9694ABSTARCT: Hematological alterations are frequent in malaria patients; the relationship between alterations in white blood cell counts and clinical status in malaria is not well understood. In Colombia, with low endemicity and unstable transmission for malaria, with malaria vivax predominance, the hematologic profile in malaria patients is not well characterized. The aim of this study was to characterize the leukogram in malaria patients and to analyze its alterations in relation to the clinical status. METHODS: 888 leukogram profiles of malaria patients from different Colombian regions were studied: 556 with P. falciparum infection (62.6%), 313 with P. vivax infection (35.2%), and 19 with mixed infection by these species (2.1%). RESULTS: Leukocyte counts at diagnosis were within normal range in 79% of patients and 18% had leucopenia; the most frequent alteration was lymphopenia (54%) followed by monocytosis (11%); the differential granulocyte count in 298 patients revealed eosinophilia (15%) and high basophil counts (8%). Leukocytosis, eosinopenia, and neutrophilia were associated with clinical complications. The utility of changes in leukocyte counts as markers of severity should be explored in depth. A better understanding of these hematological parameters will allow their use in prompt diagnosis of malaria complications and monitoring treatment response.11application/pdfengHindawi Publishing CorporationEgiptohttp://creativecommons.org/licenses/by/2.5/co/https://creativecommons.org/licenses/by/4.0/Atribución 2.5info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Malaria FalciparumMalaria VivaxRecuento de LeucocitosLeukocyte CountMalaria, FalciparumMalaria, VivaxMalariaLeukogram Profile and Clinical Status in vivax and falciparum Malaria Patients from ColombiaArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionJ. Trop. Med1212015ournal of Tropical MedicinePublicationORIGINALTobonCastañoAlberto_2015_LeukogramProfileVivax.pdfTobonCastañoAlberto_2015_LeukogramProfileVivax.pdfArtículo de investigaciónapplication/pdf2204298https://bibliotecadigital.udea.edu.co/bitstreams/2126e450-10d8-4646-8f32-e47037b37487/download1ab9e1c8df1a0b8b4e34826de150662bMD51trueAnonymousREADCC-LICENSElicense_urllicense_urltext/plain; charset=utf-849https://bibliotecadigital.udea.edu.co/bitstreams/7d31632f-19b1-4916-863a-c95889191f64/download4afdbb8c545fd630ea7db775da747b2fMD52falseAnonymousREADlicense_textlicense_texttext/html; charset=utf-80https://bibliotecadigital.udea.edu.co/bitstreams/da454a05-8c8e-478b-9aeb-34ccfc43e1e9/downloadd41d8cd98f00b204e9800998ecf8427eMD53falseAnonymousREADlicense_rdflicense_rdfLicenciaapplication/rdf+xml; charset=utf-80https://bibliotecadigital.udea.edu.co/bitstreams/fe15c602-efcf-468f-bbed-909c4e5a2fa4/downloadd41d8cd98f00b204e9800998ecf8427eMD54falseAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstreams/e1a4e6ec-c853-4954-a141-42f438a545bf/download8a4605be74aa9ea9d79846c1fba20a33MD55falseAnonymousREADTEXTTobonCastañoAlberto_2015_LeukogramProfileVivax.pdf.txtTobonCastañoAlberto_2015_LeukogramProfileVivax.pdf.txtExtracted texttext/plain54534https://bibliotecadigital.udea.edu.co/bitstreams/dfa2be52-bbe2-4275-9325-277e0a31c129/download472552db93efe839d635c6ca1bbdb180MD58falseAnonymousREADTHUMBNAILTobonCastañoAlberto_2015_LeukogramProfileVivax.pdf.jpgTobonCastañoAlberto_2015_LeukogramProfileVivax.pdf.jpgGenerated Thumbnailimage/jpeg13612https://bibliotecadigital.udea.edu.co/bitstreams/3180ff6d-531b-4388-a12b-7a6a2d519074/downloada494fda0d343e3e15886136e2d836d7aMD59falseAnonymousREAD10495/11422oai:bibliotecadigital.udea.edu.co:10495/114222025-03-26 17:41:42.671http://creativecommons.org/licenses/by/2.5/co/open.accesshttps://bibliotecadigital.udea.edu.coRepositorio Institucional de la Universidad de Antioquiaaplicacionbibliotecadigitalbiblioteca@udea.edu.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 |