Factores genéticos y epigenéticos del cáncer gástrico
ABSTRACT: Gastric cancer (GC) is the leading cause of cancer death in Colombia, gastric tumorigenesis is a gradual and long evolution process involving genetic and epigenetic changes that activate protooncogenes and inactivate tumor suppressor genes (GST). The genetic changes include loss of heteroz...
- Autores:
-
Pérez Cala, Tania
Camargo Guerrero, Mauricio
Martínez, Alonso
- Tipo de recurso:
- Review article
- Fecha de publicación:
- 2017
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- spa
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/11074
- Acceso en línea:
- http://hdl.handle.net/10495/11074
- Palabra clave:
- Neoplasias gástricas
Stomach neoplasms
Genes supresores de tumor
Genes, tumor suppressor
Oncogenes
Genética
Genetics
Metilación
Methylation
Cáncer gástrico
http://aims.fao.org/aos/agrovoc/c_24872
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-sa/2.5/co/
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| dc.title.spa.fl_str_mv |
Factores genéticos y epigenéticos del cáncer gástrico |
| dc.title.translated.spa.fl_str_mv |
Genetic and epigenetic factors of gastric cancer |
| title |
Factores genéticos y epigenéticos del cáncer gástrico |
| spellingShingle |
Factores genéticos y epigenéticos del cáncer gástrico Neoplasias gástricas Stomach neoplasms Genes supresores de tumor Genes, tumor suppressor Oncogenes Genética Genetics Metilación Methylation Cáncer gástrico http://aims.fao.org/aos/agrovoc/c_24872 |
| title_short |
Factores genéticos y epigenéticos del cáncer gástrico |
| title_full |
Factores genéticos y epigenéticos del cáncer gástrico |
| title_fullStr |
Factores genéticos y epigenéticos del cáncer gástrico |
| title_full_unstemmed |
Factores genéticos y epigenéticos del cáncer gástrico |
| title_sort |
Factores genéticos y epigenéticos del cáncer gástrico |
| dc.creator.fl_str_mv |
Pérez Cala, Tania Camargo Guerrero, Mauricio Martínez, Alonso |
| dc.contributor.author.none.fl_str_mv |
Pérez Cala, Tania Camargo Guerrero, Mauricio Martínez, Alonso |
| dc.contributor.researchgroup.spa.fl_str_mv |
Genética, Regeneración y Cáncer Bacterias & Cáncer |
| dc.subject.decs.none.fl_str_mv |
Neoplasias gástricas Stomach neoplasms Genes supresores de tumor Genes, tumor suppressor Oncogenes |
| topic |
Neoplasias gástricas Stomach neoplasms Genes supresores de tumor Genes, tumor suppressor Oncogenes Genética Genetics Metilación Methylation Cáncer gástrico http://aims.fao.org/aos/agrovoc/c_24872 |
| dc.subject.lemb.none.fl_str_mv |
Genética Genetics |
| dc.subject.agrovoc.none.fl_str_mv |
Metilación Methylation |
| dc.subject.proposal.spa.fl_str_mv |
Cáncer gástrico |
| dc.subject.agrovocuri.none.fl_str_mv |
http://aims.fao.org/aos/agrovoc/c_24872 |
| description |
ABSTRACT: Gastric cancer (GC) is the leading cause of cancer death in Colombia, gastric tumorigenesis is a gradual and long evolution process involving genetic and epigenetic changes that activate protooncogenes and inactivate tumor suppressor genes (GST). The genetic changes include loss of heterozygosity (LOH), microsatellite instability (MSI), translocations, aneuploidy, and mutations in GST; and mutations in protooncogenes or ampli cations. Meanwhile, methylation of promoters is the commonest epigenetic alteration. Actually, CG is a public health problem in the country for three factors: high rates of incidence/mortality, overruns treatments for advanced disease stages and lack of public access to services health. This review the genetic and epigenetic alterations that are found more often in CG, and its association with different types of CG. Key words: gastric cancer, genetic, methylation, oncogene, tumour suppressor genes. |
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2017 |
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2017 |
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2019-05-20T17:35:27Z |
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2019-05-20T17:35:27Z |
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Pérez T, Camargo M, Martínez A. Factores genéticos y epigenéticos del cáncer gástrico. Actual. Biol. 2017; 39 (106): 5-20. DOI: 10.17533/udea.acbi.v39n106a01 |
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0304-3584 |
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http://hdl.handle.net/10495/11074 |
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10.17533/udea.acbi.v39n106a01 |
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2145-7166 |
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Pérez T, Camargo M, Martínez A. Factores genéticos y epigenéticos del cáncer gástrico. Actual. Biol. 2017; 39 (106): 5-20. DOI: 10.17533/udea.acbi.v39n106a01 0304-3584 10.17533/udea.acbi.v39n106a01 2145-7166 |
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Universidad de Antioquia, Facultad de Ciencias Exactas y Naturales, Instituto de Biología |
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Medellín, Colombia |
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Pérez Cala, TaniaCamargo Guerrero, MauricioMartínez, AlonsoGenética, Regeneración y CáncerBacterias & Cáncer2019-05-20T17:35:27Z2019-05-20T17:35:27Z2017Pérez T, Camargo M, Martínez A. Factores genéticos y epigenéticos del cáncer gástrico. Actual. Biol. 2017; 39 (106): 5-20. DOI: 10.17533/udea.acbi.v39n106a010304-3584http://hdl.handle.net/10495/1107410.17533/udea.acbi.v39n106a012145-7166ABSTRACT: Gastric cancer (GC) is the leading cause of cancer death in Colombia, gastric tumorigenesis is a gradual and long evolution process involving genetic and epigenetic changes that activate protooncogenes and inactivate tumor suppressor genes (GST). The genetic changes include loss of heterozygosity (LOH), microsatellite instability (MSI), translocations, aneuploidy, and mutations in GST; and mutations in protooncogenes or ampli cations. Meanwhile, methylation of promoters is the commonest epigenetic alteration. Actually, CG is a public health problem in the country for three factors: high rates of incidence/mortality, overruns treatments for advanced disease stages and lack of public access to services health. This review the genetic and epigenetic alterations that are found more often in CG, and its association with different types of CG. Key words: gastric cancer, genetic, methylation, oncogene, tumour suppressor genes.RESUMEN: El cáncer gástrico (CG) es la primera causa de muerte por cáncer en Colombia, la tumorogénesis gástrica es un proceso gradual y de larga evolución que incluye cambios genéticos y epigenéticos que activan protooncogenes e inactivan genes supresores de tumor (GST). Los cambios genéticos incluyen pérdida de heterocigocidad (LOH), inestabilidad microsatelital (MSI), translocaciones, aneuploidía, y mutaciones en GST; y ampli caciones o mutaciones en protooncogenes. Por otro lado, la alteración epigenética más frecuente es la metilación de los promotores. En la actualidad, el CG es un problema de salud pública en Colombia por tres factores: las altas tasas de incidencia/mortalidad, los sobrecostos de los tratamientos de la enfermedad en estadios avanzado y la falta de acceso de la población a los servicios de salud. Esta revisión expondrá las alteraciones genéticas y epigenéticas que se encuentran con mayor frecuencia en CG, y su asociación con los diferentes tipos de CG. Palabras clave: cáncer gástrico, genes supresores de tumor, genética, metilación, oncogenes.COL0006769COL0070457application/pdfspaUniversidad de Antioquia, Facultad de Ciencias Exactas y Naturales, Instituto de BiologíaMedellín, Colombiahttps://creativecommons.org/licenses/by-nc-sa/2.5/co/https://creativecommons.org/licenses/by-nc-sa/4.0/Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Factores genéticos y epigenéticos del cáncer gástricoGenetic and epigenetic factors of gastric cancerArtículo de revisiónhttp://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTREVhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionNeoplasias gástricasStomach neoplasmsGenes supresores de tumorGenes, tumor suppressorOncogenesGenéticaGeneticsMetilaciónMethylationCáncer gástricohttp://aims.fao.org/aos/agrovoc/c_24872Actual. 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