Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain

ABSTARCT: Seven diterpenes isolated of the latex of the Euphorbia obtusifolia were evaluated as inhibitors of the NADH oxidase activity in submitochondrial particles from bovine heart. Compound 2,2,3,5,7,8,9,15-heptahydroxyjatropha-6(17),11-diene-14-one 8,9-diacetate 7-isobutyrate 2.3-bis(2-methylbu...

Full description

Autores:
Betancur Galvis, Liliana Amparo
Checa, Javier
Marco Ventura, Juan Alberto
Estornell, Ernesto
Tipo de recurso:
Article of investigation
Fecha de publicación:
2003
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/8522
Acceso en línea:
http://hdl.handle.net/10495/8522
Palabra clave:
Jatrophane Diterpenes
Látex de euphorbia obtusifolia
Actividad inhibitoria
Cadena respiratoria mitocondrial
Rights
openAccess
License
http://creativecommons.org/licenses/by/2.5/co/
id UDEA2_7453060f5dfb97cad031e66c2e9053cf
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network_acronym_str UDEA2
network_name_str Repositorio UdeA
repository_id_str
dc.title.spa.fl_str_mv Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain
title Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain
spellingShingle Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain
Jatrophane Diterpenes
Látex de euphorbia obtusifolia
Actividad inhibitoria
Cadena respiratoria mitocondrial
title_short Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain
title_full Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain
title_fullStr Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain
title_full_unstemmed Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain
title_sort Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain
dc.creator.fl_str_mv Betancur Galvis, Liliana Amparo
Checa, Javier
Marco Ventura, Juan Alberto
Estornell, Ernesto
dc.contributor.author.none.fl_str_mv Betancur Galvis, Liliana Amparo
Checa, Javier
Marco Ventura, Juan Alberto
Estornell, Ernesto
dc.contributor.researchgroup.spa.fl_str_mv Infección y Cáncer
dc.subject.none.fl_str_mv Jatrophane Diterpenes
Látex de euphorbia obtusifolia
Actividad inhibitoria
Cadena respiratoria mitocondrial
topic Jatrophane Diterpenes
Látex de euphorbia obtusifolia
Actividad inhibitoria
Cadena respiratoria mitocondrial
description ABSTARCT: Seven diterpenes isolated of the latex of the Euphorbia obtusifolia were evaluated as inhibitors of the NADH oxidase activity in submitochondrial particles from bovine heart. Compound 2,2,3,5,7,8,9,15-heptahydroxyjatropha-6(17),11-diene-14-one 8,9-diacetate 7-isobutyrate 2.3-bis(2-methylbutyrate), was the most potent inhibitor with an inhibitory concentration (IC50) value of 5.1 ± 0.2 µM. In the present study, some structure-activity trends are suggested for the inhibitory activity of these natural products on the mammalian mitochondrial respiratory chain.
publishDate 2003
dc.date.issued.none.fl_str_mv 2003
dc.date.accessioned.none.fl_str_mv 2017-10-10T16:53:50Z
dc.date.available.none.fl_str_mv 2017-10-10T16:53:50Z
dc.type.spa.fl_str_mv Artículo de investigación
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.redcol.spa.fl_str_mv https://purl.org/redcol/resource_type/ART
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dc.identifier.citation.spa.fl_str_mv Betancur Galvis, L. A., Checa, J., Marco Ventura, J. A., & Estornell, E. Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain. Planta Médica. 2003; 69: 177-178.
dc.identifier.issn.none.fl_str_mv 0032-0943
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10495/8522
dc.identifier.doi.none.fl_str_mv 10.1055/s-2003-37701
dc.identifier.eissn.none.fl_str_mv 1439-0221
identifier_str_mv Betancur Galvis, L. A., Checa, J., Marco Ventura, J. A., & Estornell, E. Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain. Planta Médica. 2003; 69: 177-178.
0032-0943
10.1055/s-2003-37701
1439-0221
url http://hdl.handle.net/10495/8522
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Planta. Med.
dc.relation.citationendpage.spa.fl_str_mv 178
dc.relation.citationissue.spa.fl_str_mv 2
dc.relation.citationstartpage.spa.fl_str_mv 177
dc.relation.citationvolume.spa.fl_str_mv 69
dc.relation.ispartofjournal.spa.fl_str_mv Planta Medica
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by/2.5/co/
dc.rights.uri.spa.fl_str_mv https://creativecommons.org/licenses/by/4.0/
dc.rights.accessrights.*.fl_str_mv Atribución 2.5
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dc.format.extent.spa.fl_str_mv 2 páginas
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dc.publisher.spa.fl_str_mv Thieme Gruppe
dc.publisher.place.spa.fl_str_mv Stuttgart, Alemania
institution Universidad de Antioquia
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spelling Betancur Galvis, Liliana AmparoCheca, JavierMarco Ventura, Juan AlbertoEstornell, ErnestoInfección y Cáncer2017-10-10T16:53:50Z2017-10-10T16:53:50Z2003Betancur Galvis, L. A., Checa, J., Marco Ventura, J. A., & Estornell, E. Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain. Planta Médica. 2003; 69: 177-178.0032-0943http://hdl.handle.net/10495/852210.1055/s-2003-377011439-0221ABSTARCT: Seven diterpenes isolated of the latex of the Euphorbia obtusifolia were evaluated as inhibitors of the NADH oxidase activity in submitochondrial particles from bovine heart. Compound 2,2,3,5,7,8,9,15-heptahydroxyjatropha-6(17),11-diene-14-one 8,9-diacetate 7-isobutyrate 2.3-bis(2-methylbutyrate), was the most potent inhibitor with an inhibitory concentration (IC50) value of 5.1 ± 0.2 µM. 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