Bisbenzylisoquinolines as modulators of chloroquine resistance in Plasmodium falciparum and multidrug resistance in tumor cells

ABSTRACT: Ten naturally occurring bisbenzylisoquinolines (BBIQ) and two dihydro derivatives belonging to five BBIQ subgroups were evaluated in vitro for their ability to inhibit Plasmodium falciparum growth and, in drug combination, to reverse the resistance to chloroquine of strain FcB1. The same a...

Full description

Autores:

Sáez Vega, Jairo Antonio
Frappier, Francois
Jossang, Akino
Soudon, Jacques
Calvo, Fabien
Rasoanaivo, Philippe
Ratsimamanga Urverg, Suzanne
Schrevel, Joseph
Grellier, Philippe

Tipo de recurso:

Article of investigation

Fecha de publicación:

1996

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/33431

Acceso en línea:

https://hdl.handle.net/10495/33431

Palabra clave:

Antimaláricos
Antimalarials
Cloroquina
Chloroquine
Farmacorresistencia Microbiana
Drug Resistance, Microbial
Resistencia a Múltiples Medicamentos
Drug Resistance, Multiple
Sinergismo Farmacológico
Drug Synergism
Plasmodium falciparum
Leucemia-Linfoma Linfoblástico de Células T Precursoras
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Relación Estructura-Actividad
Structure-Activity Relationship
Células Tumorales Cultivadas
Tumor Cells, Cultured

Rights

openAccess

License

http://creativecommons.org/licenses/by-nc-nd/2.5/co/