Low-density lipoprotein (LDL)-antioxidant biflavonoids from garcinia madruno

ABSTRACT: Six biflavonoids were isolated from G. madruno, one of which, 7''-O-(6''''-acetyl)-glucoside of morelloflavone, is a new compound identified on the basis of 1D, 2D NMR (HMQC and HMBC) spectroscopic methods and chemical evidence. The antioxidant activity of the...

Full description

Autores:
Osorio Durango, Edison
Londoño Londoño, Julián Alberto
Bastida Argengol, Jaime
Tipo de recurso:
Article of investigation
Fecha de publicación:
2013
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/20584
Acceso en línea:
http://hdl.handle.net/10495/20584
Palabra clave:
Flavonoides
Flavonoids
Lipoproteínas LDL
Lipoproteins, LDL
Guttiferae
Garcinia madruno
http://aims.fao.org/aos/agrovoc/c_3444
Rights
openAccess
License
http://creativecommons.org/licenses/by/2.5/co/
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oai_identifier_str oai:bibliotecadigital.udea.edu.co:10495/20584
network_acronym_str UDEA2
network_name_str Repositorio UdeA
repository_id_str
dc.title.spa.fl_str_mv Low-density lipoprotein (LDL)-antioxidant biflavonoids from garcinia madruno
title Low-density lipoprotein (LDL)-antioxidant biflavonoids from garcinia madruno
spellingShingle Low-density lipoprotein (LDL)-antioxidant biflavonoids from garcinia madruno
Flavonoides
Flavonoids
Lipoproteínas LDL
Lipoproteins, LDL
Guttiferae
Garcinia madruno
http://aims.fao.org/aos/agrovoc/c_3444
title_short Low-density lipoprotein (LDL)-antioxidant biflavonoids from garcinia madruno
title_full Low-density lipoprotein (LDL)-antioxidant biflavonoids from garcinia madruno
title_fullStr Low-density lipoprotein (LDL)-antioxidant biflavonoids from garcinia madruno
title_full_unstemmed Low-density lipoprotein (LDL)-antioxidant biflavonoids from garcinia madruno
title_sort Low-density lipoprotein (LDL)-antioxidant biflavonoids from garcinia madruno
dc.creator.fl_str_mv Osorio Durango, Edison
Londoño Londoño, Julián Alberto
Bastida Argengol, Jaime
dc.contributor.author.none.fl_str_mv Osorio Durango, Edison
Londoño Londoño, Julián Alberto
Bastida Argengol, Jaime
dc.contributor.researchgroup.spa.fl_str_mv Grupo de Investigación en Sustancias Bioactivas (GISB)
dc.subject.decs.none.fl_str_mv Flavonoides
Flavonoids
Lipoproteínas LDL
Lipoproteins, LDL
topic Flavonoides
Flavonoids
Lipoproteínas LDL
Lipoproteins, LDL
Guttiferae
Garcinia madruno
http://aims.fao.org/aos/agrovoc/c_3444
dc.subject.agrovoc.none.fl_str_mv Guttiferae
dc.subject.proposal.spa.fl_str_mv Garcinia madruno
dc.subject.agrovocuri.none.fl_str_mv http://aims.fao.org/aos/agrovoc/c_3444
description ABSTRACT: Six biflavonoids were isolated from G. madruno, one of which, 7''-O-(6''''-acetyl)-glucoside of morelloflavone, is a new compound identified on the basis of 1D, 2D NMR (HMQC and HMBC) spectroscopic methods and chemical evidence. The antioxidant activity of the biflavonoids against low-density lipoprotein (LDL) peroxidation induced with Cu2+, was studied by means of a TBARS assay. The antioxidant potential of a biflavonoid fraction (BF) was also evaluated and correlated with its biflavonoid content. The flavanone-(3→8'')-flavone biflavonoids displayed antioxidant activity, particularly morelloflavone, which was significantly more potent than quercetin, with a CE50 of 12.36 μg/mL. Lipid peroxidation, was also significantly reduced in the presence of the BF (EC50 = 11.85 μg/mL). These results suggest that the BF is an excellent antioxidant.
publishDate 2013
dc.date.issued.none.fl_str_mv 2013
dc.date.accessioned.none.fl_str_mv 2021-07-02T12:53:23Z
dc.date.available.none.fl_str_mv 2021-07-02T12:53:23Z
dc.type.spa.fl_str_mv Artículo de investigación
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dc.identifier.issn.none.fl_str_mv 1420-3049
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10495/20584
dc.identifier.doi.none.fl_str_mv 10.3390/molecules18056092
identifier_str_mv 1420-3049
10.3390/molecules18056092
url http://hdl.handle.net/10495/20584
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Molecules
dc.relation.citationendpage.spa.fl_str_mv 6100
dc.relation.citationissue.spa.fl_str_mv 5
dc.relation.citationstartpage.spa.fl_str_mv 6093
dc.relation.citationvolume.spa.fl_str_mv 18
dc.relation.ispartofjournal.spa.fl_str_mv Molecules
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dc.publisher.place.spa.fl_str_mv Basilea, Suiza
institution Universidad de Antioquia
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spelling Osorio Durango, EdisonLondoño Londoño, Julián AlbertoBastida Argengol, JaimeGrupo de Investigación en Sustancias Bioactivas (GISB)2021-07-02T12:53:23Z2021-07-02T12:53:23Z20131420-3049http://hdl.handle.net/10495/2058410.3390/molecules18056092ABSTRACT: Six biflavonoids were isolated from G. madruno, one of which, 7''-O-(6''''-acetyl)-glucoside of morelloflavone, is a new compound identified on the basis of 1D, 2D NMR (HMQC and HMBC) spectroscopic methods and chemical evidence. The antioxidant activity of the biflavonoids against low-density lipoprotein (LDL) peroxidation induced with Cu2+, was studied by means of a TBARS assay. The antioxidant potential of a biflavonoid fraction (BF) was also evaluated and correlated with its biflavonoid content. The flavanone-(3→8'')-flavone biflavonoids displayed antioxidant activity, particularly morelloflavone, which was significantly more potent than quercetin, with a CE50 of 12.36 μg/mL. Lipid peroxidation, was also significantly reduced in the presence of the BF (EC50 = 11.85 μg/mL). These results suggest that the BF is an excellent antioxidant.COL00103599application/pdfengMDPIBasilea, Suizahttp://creativecommons.org/licenses/by/2.5/co/https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Low-density lipoprotein (LDL)-antioxidant biflavonoids from garcinia madrunoArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionFlavonoidesFlavonoidsLipoproteínas LDLLipoproteins, LDLGuttiferaeGarcinia madrunohttp://aims.fao.org/aos/agrovoc/c_3444Molecules61005609318MoleculesPublicationORIGINALOsorioEdison_2013_DensityLipoproteinAntioxidant.pdfOsorioEdison_2013_DensityLipoproteinAntioxidant.pdfArtículo de investigaciónapplication/pdf264906https://bibliotecadigital.udea.edu.co/bitstreams/cf32e82e-4d18-4b6a-acb9-5aeb948ddea6/download1114a51f3a0d76b5506543ad5ddd8027MD51trueAnonymousREADCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8927https://bibliotecadigital.udea.edu.co/bitstreams/7d9813ab-1d11-4909-816a-bd735d1e9372/download1646d1f6b96dbbbc38035efc9239ac9cMD52falseAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstreams/1c8a577c-fe07-44e1-a14a-4db248d1a2ae/download8a4605be74aa9ea9d79846c1fba20a33MD53falseAnonymousREADTEXTOsorioEdison_2013_DensityLipoproteinAntioxidant.pdf.txtOsorioEdison_2013_DensityLipoproteinAntioxidant.pdf.txtExtracted texttext/plain25021https://bibliotecadigital.udea.edu.co/bitstreams/1c628fec-e255-4f9c-8beb-514127701ca1/downloadb1ad437dc2c90bb27ab4d394015e0c92MD56falseAnonymousREADTHUMBNAILOsorioEdison_2013_DensityLipoproteinAntioxidant.pdf.jpgOsorioEdison_2013_DensityLipoproteinAntioxidant.pdf.jpgGenerated Thumbnailimage/jpeg13948https://bibliotecadigital.udea.edu.co/bitstreams/77db1630-ee96-4c85-80be-5dc8f1a4bede/download2e2cb67664e3a09334d48755f8caf931MD57falseAnonymousREAD10495/20584oai:bibliotecadigital.udea.edu.co:10495/205842025-03-26 18:15:37.165http://creativecommons.org/licenses/by/2.5/co/open.accesshttps://bibliotecadigital.udea.edu.coRepositorio Institucional de la Universidad de Antioquiaaplicacionbibliotecadigitalbiblioteca@udea.edu.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