The 2015 IUIS Phenotypic Classification for Primary Immunodeficiencies

ABSTRACT: There are now nearly 300 single-gene inborn errors of immunity underlying phenotypes as diverse as infection, malignancy, allergy, auto-immunity, and auto-inflammation. For each of these five categories, a growing variety of phenotypes are ascribed to Primary Immunodeficiency Diseases (PID), making PIDs a rapidly expanding field of medicine. The International Union of Immunological Societies (IUIS) PID expert committee (EC) has published every other year a classification of these disorders into tables, defined by shared pathogenesis and/or clinical consequences. In 2013, the IUIS committee also proposed a more user-friendly, phenotypic classification, based on the selection of key phenotypes at the bedside. We herein propose the revised figures, based on the accompanying 2015 IUIS PID EC classification.

• Autores: Franco Restrepo, José Luis; Bousfiha, Aziz; Jeddane, Leïla; Al Herz, Waleed; Ailal, Fatima; Casanova, Jean Laurent; Chatila, Talal; Conley, Mary Ellen; Cunningham Rundles, Charlotte; Etzioni, Amos; Gaspar, H. Bobby; Holland, Steven M.; Klein, Christoph; Nonoyama, Shigeaki; Ochs, Hans D.; Oksenhendler, Eric; Picard, Capucine; Puck, Jennifer M.; Sullivan, Kathleen E.; Tang, Mimi L. K.
• Tipo de recurso: Review article
• Fecha de publicación: 2015
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/43124
• Acceso en línea: https://hdl.handle.net/10495/43124
• Palabra clave: Autoimmunity; Autoinmunidad; Expert Testimony; Testimonio de Experto; Hypersensitivity; Hipersensibilidad; Immunity; Inmunidad; Immunologic Deficiency Syndromes; Síndromes de Inmunodeficiencia; Infections; Infecciones; Inflammation; Inflamación; Neoplasms; Neoplasias; https://id.nlm.nih.gov/mesh/D015551; https://id.nlm.nih.gov/mesh/D005104; https://id.nlm.nih.gov/mesh/D006967; https://id.nlm.nih.gov/mesh/D007109; https://id.nlm.nih.gov/mesh/D007153; https://id.nlm.nih.gov/mesh/D007239; https://id.nlm.nih.gov/mesh/D007249; https://id.nlm.nih.gov/mesh/D009369
• Rights: openAccess
• License: https://creativecommons.org/licenses/by/4.0/