Apoptotic markers in protozoan parasites
ABSTRACT: The execution of the apoptotic death program in metazoans is characterized by a sequence of morphological and biochemical changes that include cell shrinkage, presentation of phosphatidylserine at the cell surface, mitochondrial alterations, chromatin condensation, nuclear fragmentation, m...
- Autores:
-
Alzate Restrepo, Juan Fernando
Jiménez Ruiz, Antonio
MacLeod, Ewan Thomas
Kurt Lüder, Carsten Günter
Fasel, Nicolas
Hurd, Hilary
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2010
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/38552
- Acceso en línea:
- https://hdl.handle.net/10495/38552
- Palabra clave:
- Apoptosis
https://id.nlm.nih.gov/mesh/D017209
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by/2.5/co/
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| dc.title.spa.fl_str_mv |
Apoptotic markers in protozoan parasites |
| title |
Apoptotic markers in protozoan parasites |
| spellingShingle |
Apoptotic markers in protozoan parasites Apoptosis https://id.nlm.nih.gov/mesh/D017209 |
| title_short |
Apoptotic markers in protozoan parasites |
| title_full |
Apoptotic markers in protozoan parasites |
| title_fullStr |
Apoptotic markers in protozoan parasites |
| title_full_unstemmed |
Apoptotic markers in protozoan parasites |
| title_sort |
Apoptotic markers in protozoan parasites |
| dc.creator.fl_str_mv |
Alzate Restrepo, Juan Fernando Jiménez Ruiz, Antonio MacLeod, Ewan Thomas Kurt Lüder, Carsten Günter Fasel, Nicolas Hurd, Hilary |
| dc.contributor.author.none.fl_str_mv |
Alzate Restrepo, Juan Fernando Jiménez Ruiz, Antonio MacLeod, Ewan Thomas Kurt Lüder, Carsten Günter Fasel, Nicolas Hurd, Hilary |
| dc.contributor.researchgroup.spa.fl_str_mv |
Grupo de Parasitología, Universidad de Antioquia |
| dc.subject.decs.none.fl_str_mv |
Apoptosis |
| topic |
Apoptosis https://id.nlm.nih.gov/mesh/D017209 |
| dc.subject.meshuri.none.fl_str_mv |
https://id.nlm.nih.gov/mesh/D017209 |
| description |
ABSTRACT: The execution of the apoptotic death program in metazoans is characterized by a sequence of morphological and biochemical changes that include cell shrinkage, presentation of phosphatidylserine at the cell surface, mitochondrial alterations, chromatin condensation, nuclear fragmentation, membrane blebbing and the formation of apoptotic bodies. Methodologies for measuring apoptosis are based on these markers. Except for membrane blebbing and formation of apoptotic bodies, all other events have been observed in most protozoan parasites undergoing cell death. However, while techniques exist to detect these markers, they are often optimised for metazoan cells and therefore may not pick up subtle differences between the events occurring in unicellular organisms and multicellular organisms. In this review we discuss the markers most frequently used to analyze cell death in protozoan parasites, paying special attention to changes in cell morphology, mitochondrial activity, chromatin structure and plasma membrane structure/permeability. Regarding classical regulators/executors of apoptosis, we have reviewed the present knowledge of caspase-like and nuclease activities. |
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2010 |
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2010 |
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2024-03-11T22:35:55Z |
| dc.date.available.none.fl_str_mv |
2024-03-11T22:35:55Z |
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Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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https://purl.org/redcol/resource_type/ART |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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Jiménez-Ruiz, A., Alzate, J. F., MacLeod, E. T., Lüder, C. G. K., Fasel, N., & Hurd, H. (2010). Apoptotic markers in protozoan parasites. Parasites & vectors, 3(1), 1-15. |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/10495/38552 |
| dc.identifier.doi.none.fl_str_mv |
10.1186/1756-3305-3-104 |
| dc.identifier.eissn.none.fl_str_mv |
1756-3305 |
| identifier_str_mv |
Jiménez-Ruiz, A., Alzate, J. F., MacLeod, E. T., Lüder, C. G. K., Fasel, N., & Hurd, H. (2010). Apoptotic markers in protozoan parasites. Parasites & vectors, 3(1), 1-15. 10.1186/1756-3305-3-104 1756-3305 |
| url |
https://hdl.handle.net/10495/38552 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Parasit. Vectors. |
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15 |
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1 |
| dc.relation.citationvolume.spa.fl_str_mv |
3 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Parasites and Vectors |
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http://creativecommons.org/licenses/by/2.5/co/ |
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https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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15 páginas |
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application/pdf |
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BMC (BioMed Central) |
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Londres, Inglaterra |
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Universidad de Antioquia |
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Alzate Restrepo, Juan FernandoJiménez Ruiz, AntonioMacLeod, Ewan ThomasKurt Lüder, Carsten GünterFasel, NicolasHurd, HilaryGrupo de Parasitología, Universidad de Antioquia2024-03-11T22:35:55Z2024-03-11T22:35:55Z2010Jiménez-Ruiz, A., Alzate, J. F., MacLeod, E. T., Lüder, C. G. K., Fasel, N., & Hurd, H. (2010). Apoptotic markers in protozoan parasites. Parasites & vectors, 3(1), 1-15.https://hdl.handle.net/10495/3855210.1186/1756-3305-3-1041756-3305ABSTRACT: The execution of the apoptotic death program in metazoans is characterized by a sequence of morphological and biochemical changes that include cell shrinkage, presentation of phosphatidylserine at the cell surface, mitochondrial alterations, chromatin condensation, nuclear fragmentation, membrane blebbing and the formation of apoptotic bodies. Methodologies for measuring apoptosis are based on these markers. Except for membrane blebbing and formation of apoptotic bodies, all other events have been observed in most protozoan parasites undergoing cell death. However, while techniques exist to detect these markers, they are often optimised for metazoan cells and therefore may not pick up subtle differences between the events occurring in unicellular organisms and multicellular organisms. In this review we discuss the markers most frequently used to analyze cell death in protozoan parasites, paying special attention to changes in cell morphology, mitochondrial activity, chromatin structure and plasma membrane structure/permeability. Regarding classical regulators/executors of apoptosis, we have reviewed the present knowledge of caspase-like and nuclease activities.COL000750615 páginasapplication/pdfengBMC (BioMed Central)Londres, Inglaterrahttp://creativecommons.org/licenses/by/2.5/co/https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Apoptotic markers in protozoan parasitesArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionApoptosishttps://id.nlm.nih.gov/mesh/D017209Parasit. 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