Synthesis and antiviral activity of scopadulcic acids analogues

ABSTRACT: The synthesis and antiviral properties of several scopadulcic acid analogues functionalized at C-6/C-7 and C-13 is reported. The preparation of advanced intermediates for the synthesis of scopadulcic acid B/scopadulciol analogues is also described. The biological study revealed the importa...

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Autores:
Betancur Galvis, Liliana Amparo
Bueno Sánchez, Juan Gabriel
Arnó, Manuel
González, Miguel Ángel
Zaragoza ́, Ramón
Tipo de recurso:
Article of investigation
Fecha de publicación:
2003
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/45278
Acceso en línea:
https://hdl.handle.net/10495/45278
Palabra clave:
Antivirales
Antiviral Agents
Scoparia
https://id.nlm.nih.gov/mesh/D000998
https://id.nlm.nih.gov/mesh/D036721
Rights
openAccess
License
Derechos reservados - Está prohibida la reproducción parcial o total de esta publicación
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dc.title.spa.fl_str_mv Synthesis and antiviral activity of scopadulcic acids analogues
title Synthesis and antiviral activity of scopadulcic acids analogues
spellingShingle Synthesis and antiviral activity of scopadulcic acids analogues
Antivirales
Antiviral Agents
Scoparia
https://id.nlm.nih.gov/mesh/D000998
https://id.nlm.nih.gov/mesh/D036721
title_short Synthesis and antiviral activity of scopadulcic acids analogues
title_full Synthesis and antiviral activity of scopadulcic acids analogues
title_fullStr Synthesis and antiviral activity of scopadulcic acids analogues
title_full_unstemmed Synthesis and antiviral activity of scopadulcic acids analogues
title_sort Synthesis and antiviral activity of scopadulcic acids analogues
dc.creator.fl_str_mv Betancur Galvis, Liliana Amparo
Bueno Sánchez, Juan Gabriel
Arnó, Manuel
González, Miguel Ángel
Zaragoza ́, Ramón
dc.contributor.author.none.fl_str_mv Betancur Galvis, Liliana Amparo
Bueno Sánchez, Juan Gabriel
Arnó, Manuel
González, Miguel Ángel
Zaragoza ́, Ramón
dc.contributor.researchgroup.spa.fl_str_mv Infección y Cáncer
dc.subject.decs.none.fl_str_mv Antivirales
Antiviral Agents
Scoparia
topic Antivirales
Antiviral Agents
Scoparia
https://id.nlm.nih.gov/mesh/D000998
https://id.nlm.nih.gov/mesh/D036721
dc.subject.meshuri.none.fl_str_mv https://id.nlm.nih.gov/mesh/D000998
https://id.nlm.nih.gov/mesh/D036721
description ABSTRACT: The synthesis and antiviral properties of several scopadulcic acid analogues functionalized at C-6/C-7 and C-13 is reported. The preparation of advanced intermediates for the synthesis of scopadulcic acid B/scopadulciol analogues is also described. The biological study revealed the importance of polar groups at C-13, while the stereochemistry at C-8 was not critical for activity.
publishDate 2003
dc.date.issued.none.fl_str_mv 2003
dc.date.accessioned.none.fl_str_mv 2025-02-28T19:54:05Z
dc.date.available.none.fl_str_mv 2025-02-28T19:54:05Z
dc.type.spa.fl_str_mv Artículo de investigación
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dc.type.redcol.spa.fl_str_mv https://purl.org/redcol/resource_type/ART
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dc.identifier.issn.none.fl_str_mv 0040-4020
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10495/45278
dc.identifier.doi.none.fl_str_mv 10.1016/S0040-4020(03)01071-8
dc.identifier.eissn.none.fl_str_mv 1464-5416
identifier_str_mv 0040-4020
10.1016/S0040-4020(03)01071-8
1464-5416
url https://hdl.handle.net/10495/45278
dc.language.iso.spa.fl_str_mv eng
language eng
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dc.relation.citationendpage.spa.fl_str_mv 6464
dc.relation.citationissue.spa.fl_str_mv 34
dc.relation.citationstartpage.spa.fl_str_mv 6455
dc.relation.citationvolume.spa.fl_str_mv 59
dc.relation.ispartofjournal.spa.fl_str_mv Tetrahedron
dc.rights.uri.spa.fl_str_mv Derechos reservados - Está prohibida la reproducción parcial o total de esta publicación
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
dc.format.extent.spa.fl_str_mv 10 páginas
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dc.publisher.spa.fl_str_mv Elsevier
dc.publisher.place.spa.fl_str_mv Oxford, Inglaterra
institution Universidad de Antioquia
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spelling Betancur Galvis, Liliana AmparoBueno Sánchez, Juan GabrielArnó, ManuelGonzález, Miguel ÁngelZaragoza ́, RamónInfección y Cáncer2025-02-28T19:54:05Z2025-02-28T19:54:05Z20030040-4020https://hdl.handle.net/10495/4527810.1016/S0040-4020(03)01071-81464-5416ABSTRACT: The synthesis and antiviral properties of several scopadulcic acid analogues functionalized at C-6/C-7 and C-13 is reported. The preparation of advanced intermediates for the synthesis of scopadulcic acid B/scopadulciol analogues is also described. 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