Biological activities of 4H-thiochromen-4-one 1,1-dioxide derivatives against tropical disease parasites: A target-based drug design approach
ABSTRACT: A promising strategy for developing novel therapies against tropical diseases, including malaria, leishmaniasis, and trypanosomiasis, is to detect biological targets such as trypanothione reductase, a vital parasite enzyme that regulates oxidative stress. This enzyme is highly selective an...
- Autores:
-
Ortiz Bonilla, Cristian
Robledo Restrepo, Sara María
Echeverri López, Luis Fernando
Vargas Cano, Esteban
Quiñones Fletcher, Winston
Breuning, Matthias
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2023
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/42187
- Acceso en línea:
- https://hdl.handle.net/10495/42187
- Palabra clave:
- Medicina Tropical
Tropical Medicine
Especies Reactivas de Oxígeno
Reactive Oxygen Species
Regulación Alostérica
Allosteric Regulation
https://id.nlm.nih.gov/mesh/D014330
https://id.nlm.nih.gov/mesh/D017382
https://id.nlm.nih.gov/mesh/D000494
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-nd/2.5/co/