A Genomewide Admixture Map for Latino Populations

ABSTRACT: Admixture mapping is an economical and powerful approach for localizing disease genes in populations of recently mixed ancestry and has proven successful in African Americans. The method holds equal promise for Latinos, who typically inherit a mix of European, Native American, and African ancestry. However, admixture mapping in Latinos has not been practical because of the lack of a map of ancestry-informative markers validated in Native American and other populations. To address this, we screened multiple databases, containing millions of markers, to identify 4,186 markers that were putatively informative for determining the ancestry of chromosomal segments in Latino populations. We experimentally validated each of these markers in at least 232 new Latino, European, Native American, and African samples, and we selected a subset of 1,649 markers to form an admixture map. An advantage of our strategy is that we focused our map on markers distinguishing Native American from other ancestries and restricted it to markers with very similar frequencies in Europeans and Africans, which decreased the number of markers needed and minimized the possibility of false disease associations. We evaluated the effectiveness of our map for localizing disease genes in four Latino populations from both North and South America.

• Autores: Price, Alkes; Patterson, Nick; Yu, Fuli; Cox, David; Waliszewska, Alicja; McDonald, Gavin; Tandon, Arti; Schirmer, Christine; Neubauer, Julie; Bedoya Berrío, Gabriel de Jesús; Duque Vélez, Constanza Elena; Villegas Perrasse, Alberto; Bortolini, María Cátira; Salzano, Francisco Mauro; Gallo, Carla; Mazzotti, Guido; Tello Ruiz, Marcela; Riba, Laura; Aguilar Salinas, Carlos Alberto; Canizales Quinteros, Samuel; Menjívar Iraheta, Marta Alicia; Klitz, William; Henderson, Brian; Haiman, Christopher; Winkler, Cheryl; Tusie Luna, Teresa; Ruíz Linares, Andrés; Reich, David
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2007
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/26745
• Acceso en línea: http://hdl.handle.net/10495/26745
• Palabra clave: Alelos; Alleles; Grupo de Ascendencia Continental Africana; African Continental Ancestry Group; Estudios de Casos y Controles; Case-Control Studies; Mapeo Cromosómico; Chromosome Mapping; Cromosomas Humanos; Chromosomes, Human; Bases de Datos Genéticas; Databases, Genetic; Marcadores Genéticos; Genetic Markers; Predisposición Genética a la Enfermedad; Genetic Predisposition to Disease; Indios Norteamericanos; Indians, North American; Genética de Población; Genetics, Population
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc-nd/2.5/co/