IgG4-related Disease : A Concise Review of the Current Literature

ABSTRACT: IgG4-related disease is the term used to refer to a condition characterized by a lymphoplasmacytic infiltrate, fibrosis and an increased number of IgG4+ cells present in tissue, in most cases, with an elevated serum IgG4 level. This disease frequently affects the pancreas, salivary glands and lymph nodes, but can involve almost any tissue. Its etiology and the exact role of the different inflammatory cells in the damage to the target organ is still unclear. As yet, there is no international consensus about diagnostic criteria for the disease, but there are important advances in its treatment and in the quest to achieve remission. We include a review of the history, possible pathogenesis, clinical manifestations, diagnostic approach and available therapeutic approaches.

• Autores: Ardila Suárez, Oscar; Gómez Puerta, José Alfredo; Andy, Abril
• Tipo de recurso: Review article
• Fecha de publicación: 2017
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng; spa
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/29759
• Acceso en línea: https://hdl.handle.net/10495/29759
• Palabra clave: Pancreatitis Autoinmune; Autoimmune pancreatitis; Enfermedad de Mikulicz; Mikulicz' Disease; Enfermedad Relacionada con Inmunoglobulina G4; Immunoglobulin G4-Related Disease
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc-nd/2.5/co/