Antiparasitic bromotyrosine derivatives from the marine sponge Verongula rigida

ABSTARCT: Nine bromotyrosine-derived compounds were isolated from the Caribbean marine sponge Verongula rigida. Two of them, aeroplysinin-1 (1) and dihydroxyaerothionin (2), are known compounds for this species, and the other seven are unknown compounds for this species, namely: 3,5-dibromo-N,N,N-trimethyltyraminium (3), 3,5-dibromo-N,N,N, O-tetramethyltyraminium (4), purealidin R (5), 19-deoxyfistularin 3 (6), purealidin B (7), 11-hydroxyaerothionin (8) and fistularin-3 (9). Structural determination of the isolated compounds was performed using one- and two-dimensional NMR, MS and other spectroscopy data. All isolated compounds were screened for their in vitro activity against three parasitic protozoa: Leishmania panamensis, Plasmodium falciparum and Trypanosoma cruzi. Compounds 7 and 8 showed selective antiparasitic activity at 10 and 5 μM against Leishmania and Plasmodium parasites, respectively. Cytotoxicity of these compounds on a human promonocytic cell line was also assessed.

• Autores: Galeano Jaramillo, Elkin de Jesús; Thomas, Oliver P.; Robledo Restrepo, Sara María; Muñoz Herrera, Diana Lorena; Martínez Martínez, Alejandro
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2011
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/13067
• Acceso en línea: http://hdl.handle.net/10495/13067
• Palabra clave: Antiparasitarios; Agentes antiparasitarios; Antiparasitic agents; Esponjas; sponges; Bromotirosina; Esponja marina Verongula rigida; http://aims.fao.org/aos/agrovoc/c_7321
• Rights: openAccess
• License: https://creativecommons.org/licenses/by/2.5/co/