Bacterial Meningitis in Neonates: A Multicenter Descriptive Study in the City of Medellín, Colombia

ABSTRACT: Introduction: Bacterial meningitis is a severe infection requiring early empirical therapeutic intervention. In Colombia, there is limited information regarding this disease in the neonatal stage, necessitating up-to-date data to guide timely antibiotic therapy. Objective: To describe the clinical, microbiological, and epidemiological characteristics of neonatal bacterial meningitis in three hospital centers in the city of Medellín during the years 2010 to 2019. Methods: A descriptive study was conducted using electronic medical records of newborns treated in three hospitals in Medellín from 2010 to 2019. Clinical records with a discharge diagnosis of bacterial meningitis and corresponding microbiological isolation were reviewed. Data were extracted from SAP® and Servinte Clinical Suite Enterprise® and recorded in a Google® spreadsheet. Results: A total of 125 records with a diagnosis of neonatal meningitis were reviewed with only 42 cases meeting microbiological isolation criteria.The mean gestational age was 35 weeks, and the most frequentlyisolated pathogens were Escherichia coli (40.5%) and Streptococcus agalactiae (40.5%). In 71.4% of cases, the meningitis was classified as late-onset according to age. Primary symptoms included irritability (56.1%) and fever (48.8%). Conclusions: The most common causative agents identified in this population were S. agalactiae and E. coli. Principal symptoms were irritability and fever. A significant proportion of neonates did not present suggestive symptoms of central nervous system infection. Additionally, prematurity was predominant in the studied population.

• Autores: Zúñiga Muñoz, Yulieth Alexandra; Vélez Martínez, Luis Felipe; López García, Leidy Carolina; Beltrán Arroyave, Claudia Patricia; Cornejo Ochoa, José William
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2023
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/39271
• Acceso en línea: https://hdl.handle.net/10495/39271
• Palabra clave: Meningitis, Bacterial; Meningitis Bacterianas; Newborn Infant; Recién Nacido; Electronic Health Records; Registros Electrónicos de Salud; Anti-Infective Agents; Antiinfecciosos; Sepsis; Sepsis; Pleocytosis; Leucocitosis; https://id.nlm.nih.gov/mesh/D016920; https://id.nlm.nih.gov/mesh/D007231; https://id.nlm.nih.gov/mesh/D057286; https://id.nlm.nih.gov/mesh/D000890; https://id.nlm.nih.gov/mesh/D018805; https://id.nlm.nih.gov/mesh/D007964
• Rights: openAccess
• License: https://creativecommons.org/licenses/by-nc-sa/4.0/