Leishmanicidal and trypanocidal activity of Sapindus saponaria
ABSTRACT: Leishmaniasis and trypanosomiasis are parasitic diseases with a high infection rate, being a serious public health issue in the new world. Unfortunately, there are few available commercial drugs, poorly efficient and with increasing parasite resistance. Under these conditions, there is a n...
- Autores:
-
Correa Garcés, Edwin Andrés
Quiñones Fletcher, Winston
Robledo Restrepo, Sara María
Carrillo Bonilla, Lina María
Archbold Joseph, Rosendo
Torres, Fernando
Escobar Peláez, Gustavo
Herrera Loaiza, Natalia Andrea
Echeverri López, Luis Fernando
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2014
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/22183
- Acceso en línea:
- http://hdl.handle.net/10495/22183
- Palabra clave:
- Leishmaniasis
Tripanosomosis
Trypanosomosis
Sapindus saponaria
Saponinas triterpenicas
http://aims.fao.org/aos/agrovoc/c_7988
https://id.nlm.nih.gov/mesh/D007896
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-nd/4.0/
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| dc.title.spa.fl_str_mv |
Leishmanicidal and trypanocidal activity of Sapindus saponaria |
| dc.title.translated.spa.fl_str_mv |
Actividad leishmanicida y tripanocida de Sapindus saponaria |
| title |
Leishmanicidal and trypanocidal activity of Sapindus saponaria |
| spellingShingle |
Leishmanicidal and trypanocidal activity of Sapindus saponaria Leishmaniasis Tripanosomosis Trypanosomosis Sapindus saponaria Saponinas triterpenicas http://aims.fao.org/aos/agrovoc/c_7988 https://id.nlm.nih.gov/mesh/D007896 |
| title_short |
Leishmanicidal and trypanocidal activity of Sapindus saponaria |
| title_full |
Leishmanicidal and trypanocidal activity of Sapindus saponaria |
| title_fullStr |
Leishmanicidal and trypanocidal activity of Sapindus saponaria |
| title_full_unstemmed |
Leishmanicidal and trypanocidal activity of Sapindus saponaria |
| title_sort |
Leishmanicidal and trypanocidal activity of Sapindus saponaria |
| dc.creator.fl_str_mv |
Correa Garcés, Edwin Andrés Quiñones Fletcher, Winston Robledo Restrepo, Sara María Carrillo Bonilla, Lina María Archbold Joseph, Rosendo Torres, Fernando Escobar Peláez, Gustavo Herrera Loaiza, Natalia Andrea Echeverri López, Luis Fernando |
| dc.contributor.author.none.fl_str_mv |
Correa Garcés, Edwin Andrés Quiñones Fletcher, Winston Robledo Restrepo, Sara María Carrillo Bonilla, Lina María Archbold Joseph, Rosendo Torres, Fernando Escobar Peláez, Gustavo Herrera Loaiza, Natalia Andrea Echeverri López, Luis Fernando |
| dc.contributor.researchgroup.spa.fl_str_mv |
Programa de Estudio y Control de Enfermedades Tropicales (PECET) Química Orgánica de Productos Naturales |
| dc.subject.decs.none.fl_str_mv |
Leishmaniasis |
| topic |
Leishmaniasis Tripanosomosis Trypanosomosis Sapindus saponaria Saponinas triterpenicas http://aims.fao.org/aos/agrovoc/c_7988 https://id.nlm.nih.gov/mesh/D007896 |
| dc.subject.agrovoc.none.fl_str_mv |
Tripanosomosis Trypanosomosis |
| dc.subject.proposal.spa.fl_str_mv |
Sapindus saponaria Saponinas triterpenicas |
| dc.subject.agrovocuri.none.fl_str_mv |
http://aims.fao.org/aos/agrovoc/c_7988 |
| dc.subject.meshuri.none.fl_str_mv |
https://id.nlm.nih.gov/mesh/D007896 |
| description |
ABSTRACT: Leishmaniasis and trypanosomiasis are parasitic diseases with a high infection rate, being a serious public health issue in the new world. Unfortunately, there are few available commercial drugs, poorly efficient and with increasing parasite resistance. Under these conditions, there is a need for new molecules to develop new and better drugs. One approach to carry out this search is using traditional medicine as information source to obtain new molecules or extracts to control these parasite diseases. Sapindus saponaria (Sapindaceae) fruit resin is used in Colombia to treat ulcers caused by Leishmaniasis. In a bioguided study, we have analyzed the in vitro effect of fruit resin, chromatographical fractions from fruit resin and also pure compounds against Leishmania species (L. panamensis, L. braziliensis, L. amazonensis and L. donovani) and Trypanosoma cruzi. The in vivo antileishmanial effect was established under the hamster model for cutaneous leishmaniasis by L. panamensis; refined extract of S. saponaria and pure saponins displayed high in vitro and in vivo activity as leishmanicides. In addition, extracts caused low viability on T. cruzi amastigotes. The use of the crude extract can be a good alternative against cutaneous leishmaniasis, due to its activity, reduced hemolytic effect, and easy production procedures. |
| publishDate |
2014 |
| dc.date.issued.none.fl_str_mv |
2014 |
| dc.date.accessioned.none.fl_str_mv |
2021-09-04T02:37:09Z |
| dc.date.available.none.fl_str_mv |
2021-09-04T02:37:09Z |
| dc.type.spa.fl_str_mv |
Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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https://purl.org/redcol/resource_type/ART |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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publishedVersion |
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0717-7917 |
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http://hdl.handle.net/10495/22183 |
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0717-7917 |
| url |
http://hdl.handle.net/10495/22183 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Bol. latinoam. Caribe plantas med. aromát. |
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323 |
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4 |
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311 |
| dc.relation.citationvolume.spa.fl_str_mv |
13 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Boletín latinoamericano y del Caribe de plantas medicinales y aromáticas |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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http://creativecommons.org/licenses/by-nc-nd/2.5/co/ |
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openAccess |
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Cooperación Latinoamericana y Caribeña en Plantas Medicinales y Aromáticas |
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Santiago de Chile, Chile |
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Universidad de Antioquia |
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Correa Garcés, Edwin AndrésQuiñones Fletcher, WinstonRobledo Restrepo, Sara MaríaCarrillo Bonilla, Lina MaríaArchbold Joseph, RosendoTorres, FernandoEscobar Peláez, GustavoHerrera Loaiza, Natalia AndreaEcheverri López, Luis FernandoPrograma de Estudio y Control de Enfermedades Tropicales (PECET)Química Orgánica de Productos Naturales2021-09-04T02:37:09Z2021-09-04T02:37:09Z20140717-7917http://hdl.handle.net/10495/22183ABSTRACT: Leishmaniasis and trypanosomiasis are parasitic diseases with a high infection rate, being a serious public health issue in the new world. Unfortunately, there are few available commercial drugs, poorly efficient and with increasing parasite resistance. Under these conditions, there is a need for new molecules to develop new and better drugs. One approach to carry out this search is using traditional medicine as information source to obtain new molecules or extracts to control these parasite diseases. Sapindus saponaria (Sapindaceae) fruit resin is used in Colombia to treat ulcers caused by Leishmaniasis. In a bioguided study, we have analyzed the in vitro effect of fruit resin, chromatographical fractions from fruit resin and also pure compounds against Leishmania species (L. panamensis, L. braziliensis, L. amazonensis and L. donovani) and Trypanosoma cruzi. The in vivo antileishmanial effect was established under the hamster model for cutaneous leishmaniasis by L. panamensis; refined extract of S. saponaria and pure saponins displayed high in vitro and in vivo activity as leishmanicides. In addition, extracts caused low viability on T. cruzi amastigotes. The use of the crude extract can be a good alternative against cutaneous leishmaniasis, due to its activity, reduced hemolytic effect, and easy production procedures.RESUMEN: La Leishmaniasis y la tripanosomiasis son enfermedades parasitarias con una alta incidencia, siendo un serio asunto de salud pública en el nuevo mundo. Desafortunadamente, hay pocas drogas comerciales disponibles, con pobre eficiencia y con una creciente resistencia parasitaria. Bajo esas condiciones, se necesitan nuevas moléculas para desarrollar nuevas y mejores drogas. Una aproximación para llevar a cabo esa búsqueda es usar la medicina tradicional como fuente de información para obtener nuevas moléculas o extractos para controlar esas enfermedades parasitarias. La resina de Sapindus saponaria (Sapindaceae) se usa en Colombia para tratar úlceras causadas por la Leishmaniasis. En un estudio bioguiado, se analizó el efecto in vitro de varios extractos de la resina, sus fracciones cromatográficas y algunos compuestos puros, contra varias especies de Leishmania (L. panamensis, L. braziliensis, L. amazonensis y L. donovani) panamensis y Trypanosoma cruzi. El efecto lesihmanicida in vivo fue establecido usando el modelo en hamster de leishmaniasis cutánea producida por L. panamensis; los extractos refinados de S. saponaria y las saponinas puras mostraron alta actividad in vitro e in vivo como leishmanicidas. Además, los extractos causaron una baja viabilidad en amastigotes de T. cruzi. El uso de extractos refinados en vez de saponinas puras podría ser una buena alternativa contra leishmaniasis cutánea debido a su actividad, poco efecto hemolítico y procedimientos de producción mucho más fáciles.COL0015339COL001509914application/pdfengCooperación Latinoamericana y Caribeña en Plantas Medicinales y AromáticasSantiago de Chile, Chilehttps://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/2.5/co/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Leishmanicidal and trypanocidal activity of Sapindus saponariaActividad leishmanicida y tripanocida de Sapindus saponariaArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionLeishmaniasisTripanosomosisTrypanosomosisSapindus saponariaSaponinas triterpenicashttp://aims.fao.org/aos/agrovoc/c_7988https://id.nlm.nih.gov/mesh/D007896Bol. latinoam. 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