Actividad inmunomoduladora de las estatinas y su efecto potencial sobre las células T reguladoras FOXP3+

ABSTRACT: Statins are a group of drugs that inhibit the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase, which limits cholesterol synthesis and production of isoprenoid compounds, phenomena responsible for the reduction of atherosclerotic disease in individuals with hypercholesterolemia. Due to the wide prescription and use of these drugs, some additional beneficial effects have been observed in various clinical settings, mainly related to the decreased production of isoprenoid compounds. Some of these effects have been associated with the modulation of the immune system, but their effect on regulatory T cells (Treg) has not been well studied, despite the fact these cells are crucial to regulate the intensity of the immune response and to preserve immune homeostasis. This review focuses on the common pathways through which statins and Treg cells interact to regulate the immune response. Although the results from early investigations show that statins increase the frequency and suppressive capacity of Treg cells, further research is required to determine whether that relationship produces beneficial or harmful consequences for the immune regulation in different clinical settings.

• Autores: Rodríguez Perea, Ana Lucía; Montoya Guarín, Carlos Julio; Velilla Hernández, Paula Andrea
• Tipo de recurso: Review article
• Fecha de publicación: 2011
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: spa
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/12877
• Acceso en línea: http://hdl.handle.net/10495/12877
• Palabra clave: Factores de Transcripción Forkhead; Inhibidores de Hidroximetilglutaril-CoA Reductasas; Inmunomodulación
• Rights: openAccess
• License: https://creativecommons.org/licenses/by-nc-sa/2.5/co/