Minocycline mitigates Aβ and TAU pathology, neuronal dysfunction, and death in the PSEN1 E280A cholinergic-like neurons model of familial Alzheimer’s disease

ABSTRACT: Familial Alzheimer's disease (FAD) presenilin 1 E280A (PSEN1 E280A) is a severe neurological condition due to the loss of cholinergic neurons (ChNs), accumulation of amyloid beta (Aβ), and abnormal phosphorylation of the TAU protein. Up to date, there are no effective therapies availa...

Full description

Autores:

Giraldo Berrío, Daniela
Jiménez del Río, Marlene
Vélez Pardo, Carlos Alberto

Tipo de recurso:

Article of investigation

Fecha de publicación:

2024

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/42374

Acceso en línea:

https://hdl.handle.net/10495/42374

Palabra clave:

Enfermedad de Alzheimer
Alzheimer Disease
Apoptosis
Caspasa 3
Caspase 3
Proteína Desglicasa DJ-1
Protein Deglycase DJ-1
Péptidos beta-Amiloides
Amyloid beta-Peptides
Peróxido de Hidrógeno
Hydrogen Peroxide
Minociclina
Minocycline
https://id.nlm.nih.gov/mesh/D001618
https://id.nlm.nih.gov/mesh/D017209
https://id.nlm.nih.gov/mesh/D053148
https://id.nlm.nih.gov/mesh/D000071617
https://id.nlm.nih.gov/mesh/D016229
https://id.nlm.nih.gov/mesh/D006861
https://id.nlm.nih.gov/mesh/D008911

Rights

openAccess

License

http://creativecommons.org/licenses/by-nc-nd/2.5/co/