Variant in CAPN10 gene and environmental factors show evidence of association with excess weight among young people in a Colombian population

ABSTRACT: Obesity results from interaction between genetic and environmental risk factors. Objective: To evaluate the effect of three gene variants and environmental factors on obesity and overweight in young people aged 10 to 18 years in a Colombian population. Materials and methods: A total of 424 subjects were selected and separated into three groups for a cross-sectional study; 100 obese and 112 overweight subjects were matched with 212 normal-weight controls. Associations were evaluated between excess weight and three genetic polymorphisms (UCP3- rs1800849, FTO-rs17817449, and CAPN10-rs3842570), as well as the family history, the time spent watching television and playing video games, and the diet. Results: A family history of obesity, the time spent watching television and playing video games, the lack of breastfeeding, a low consumption of cereals, legumes, fruits, vegetables, and a high consumption of fast foods were characteristics typically found in obese individuals compared to controls. A significant association between genotype I/I (SNP19 of CAPN10) and excess weight was found even with an active lifestyle. In addition, significant associations between the C/C genotype of the UCP3 gene and the G/G and T/T genotypes of the FTO gene and excess weight were found only in young sedentary individuals. Conclusions: In this population, inadequate diet and sedentary lifestyle increased the risk of excess weight. Genotype I/I of SNP19 in CAPN10 was significantly associated with excess weight. In contrast, FTO and UCP3 variants exhibited effects only in sedentary environments.

• Autores: Orozco, Ana Carolina; Muñoz Contreras, Angélica María; Velásquez Rodríguez, Claudia María; Uscátegui Peñuela, Rosa María; Parra Marín, María Victoria; Patiño Villada, Fredy Alonso; Manjarrés Correa, Luz Mariela; Parra Sosa, Beatriz Elena; Estrada Restrepo, Alejandro; Agudelo Ochoa, Gloria María
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2014
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/12068
• Acceso en línea: http://hdl.handle.net/10495/12068
• Palabra clave: Obesity; Obesidad; Adolescent; Adolescente; Risk factors; Factores de riesgo; Motor activity; Actividad motora; Colombia
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc-nd/2.5/co/