Proinflammatory Differentiation of Macrophages Through Microparticles That Form Immune Complexes Leads to T- and B-Cell Activation in Systemic Autoimmune Diseases

ABSTRACT: Patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) demonstrate increased circulating microparticles (MP). These vesicles, primarily those that form immune complexes (MP-IC), may activate monocytes. We evaluated the effect of MP and MP-IC in the differentiation o...

Full description

Autores:

Burbano Arciniegas, Catalina
Villar Vesga, Juan Manuel
Vásquez Duque, Gloria María
Muñoz Vahos, Carlos
Rojas López, Mauricio
Castaño Monsalve, Diana María

Tipo de recurso:

Article of investigation

Fecha de publicación:

2019

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/43135

Acceso en línea:

https://hdl.handle.net/10495/43135

Palabra clave:

Enfermedades Autoinmunes
Autoimmune Diseases
Linfocitos B
B-Lymphocytes
Artritis Reumatoide
Arthritis, Rheumatoid
Biomarcadores
Biomarkers
Diferenciación Celular
Cell Differentiation
Micropartículas Derivadas de Células - metabolismo
Cell-Derived Microparticles - metabolism
Técnicas de Cocultivo
Coculture Techniques
Citocinas - metabolismo
Cytokines - metabolism
Mediadores de Inflamación
Inflammation Mediators
Activación de Linfocitos
Lymphocyte Activation
Macrófagos
Macrophages
Fagocitos
Phagocytes
Linfocitos T
T-Lymphocytes
https://id.nlm.nih.gov/mesh/D001327
https://id.nlm.nih.gov/mesh/D001402
https://id.nlm.nih.gov/mesh/D001172
https://id.nlm.nih.gov/mesh/D015415
https://id.nlm.nih.gov/mesh/D002454
https://id.nlm.nih.gov/mesh/D055252
https://id.nlm.nih.gov/mesh/D018920
https://id.nlm.nih.gov/mesh/D016207
https://id.nlm.nih.gov/mesh/D018836
https://id.nlm.nih.gov/mesh/D008213
https://id.nlm.nih.gov/mesh/D008264
https://id.nlm.nih.gov/mesh/D010586
https://id.nlm.nih.gov/mesh/D013601

Rights

openAccess

License

https://creativecommons.org/licenses/by/4.0/