Antibody Response to Plasmodium Vivax Antigens in Fy-Negative Individuals From the Colombian Pacific Coast

ABSTRACT: The Duffy antigen (Fy) is necessary for Plasmodium vivax invasion of human erythrocytes. Some populations have a highly prevalent Fy-negative phenotype; such persons are naturally protected from P. vivax blood infection but are expected to completely support the P. vivax pre-erythrocytic cycle, representing a valuable model for studying the immune response during these parasitic stages. We typed 214 individuals, mostly Afro-Colombians, from a P. vivax-endemic area for Fy expression and determined the antibody response to P. vivax pre-erythrocytic (sporozoites and CS) and blood-stage antigens (blood forms, P. vivax merozoite surface protein 1, and P. vivax Duffy binding protein [PvDBP]). Antibody titers to P. vivax circumsporozoite protein, P11, and N-terminal peptides and the number of responders were similar in Fy-negative and Fy-positive individuals. The number of responders to sporozoites, blood forms, and PvDBP were different between these groups. Thus, Fy-negative individuals from malaria-endemic areas can be used to study the immune response to the P. vivax liver phase without interference of the erythrocytic cycle

• Autores: Herrera Valencia, Socrates; Gómez, Andrés; Vera Lezcano, Omaira; Vergara, Juana; Valderrama Aguirre, Augusto; Maestre Buitrago, Amanda Elena; Méndez Paz, Fabian; Wang, Ruibing; Chitnis, Chetan E; Yazdani, Syed S; Arévalo Herrera, Myriam
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2005
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/21376
• Acceso en línea: http://hdl.handle.net/10495/21376
• Palabra clave: Malaria; Plasmodium vivax; Antígenos; Antigens
• Rights: openAccess
• License: http://creativecommons.org/licenses/by/2.5/co/