Frequency of Aspirin Resistance in Ischemic Stroke Patients and Healthy Controls from Colombia

ABSTRACT: Objective: To evaluate the aspirin resistance prevalence in patients with previous ischemic cerebrovascular disease undergoing aspirin therapy for secondary prevention. Materials and methods: Three hundred fifty patients presenting ischemic strokes and 100 healthy controls under aspirin treatment were evaluated using the optic platelet aggregation test. Results: Aspirin resistance was found in 7.4% of the patients with ischemic stroke and 4% of controls. Aspirin resistance was associated with stroke recurrence in univariate analysis (p = 0.004). Aspirin resistance was not associated with smoking, diabetes, or hypercholesterolemia. Conclusion: Aspirin resistance is present in Colombian patients with ischemic stroke as well as in healthy controls.

• Autores: Bedoya Berrío, Gabriel de Jesús; Román González, Alejandro; Naranjo González, Carlos Andrés; Cardona Maya, Walter Darío; Vallejo, Dionis; García, Francisco; Franco, Cesar; Álvarez Pelaéz, María Leonor; Tobón Acosta, Luis Ignacio; López, Marta Ibeth; Rúa Molina, Diana Carolina; Cadavid Jaramillo, Ángela Patricia; Torres Hernández, José Domingo
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2021
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/41097
• Acceso en línea: https://hdl.handle.net/10495/41097
• Palabra clave: Aspirina; Aspirin; Accidente Cerebrovascular Isquémico; Ischemic Stroke; Colombia; Resistencia a Medicamentos; Drug Resistance; Agregación Plaquetaria; Platelet Aggregation; https://id.nlm.nih.gov/mesh/D001241; https://id.nlm.nih.gov/mesh/D000083242; https://id.nlm.nih.gov/mesh/D003105; https://id.nlm.nih.gov/mesh/D004351; https://id.nlm.nih.gov/mesh/D010974
• Rights: openAccess
• License: http://creativecommons.org/licenses/by/2.5/co/