CFD Prediction of Heterogeneities in the Scale up of Liquid-Liquid Dispersions

In this work simulations were developed in order to allow the examinations of heterogeneities in the scale up of liquid-liquid dispersions (oil-water) in 3 and 300 L stirred tank bioreactors using CFD simulations (Computational Fluid Dynamics). The effects of turbulence, rotating flow, drop breakage were simulated by using the k-e, MRF (Multiple Reference Frame) and PBM (Population Balance Model), respectively, providing detailed information of important bioreactor conditions. CFD modeling predicts with good approach hydrodynamic trends which can affect the liquid-liquid dispersion process of large scale bioreactors. Motivated by these results, CFD simulations are qualified as a very promising tool for predicting hydrodynamics and drop sizes especially useful for liquid-liquid applications which are characterized by the challenging problem of emulsion stability due to undesired drop and heterogeneities in the scale up process.

• Autores: Niño Lopez, Lilibet Caridad; Gelves Zambrano, Germán Ricardo
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2014
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/46336
• Acceso en línea: https://hdl.handle.net/10495/46336
• Palabra clave: Dinámica de fluidos computacional; Computational fluid dynamics; Biorreactores - Dinámica de fluidos; Bioreactors - Fluid dynamics; Hidrodinámica; Hydrodynamics; Bioreactors; Biorreactor; http://aims.fao.org/aos/agrovoc/c_27469; http://id.loc.gov/authorities/subjects/sh2007008173; http://id.loc.gov/authorities/subjects/sh88004258
• Rights: openAccess
• License: http://creativecommons.org/licenses/by/4.0/