Non-Newtonian Behavior Effect on Gas-liquid Mass Transfer using an Anchor Impeller for CSTR Bioreactors: A CFD Approach

ABSTRACT: Objectives: kLa mass transfer coefficient was predicted using CFD (computational fluid dynamics) for analyzing non-newtonian effects on gas liquid mass transfer in a 10 L bioreactor stirred with an Anchor Impeller. Methods/Statistical Analysis: The set up bioreactor configurations were defined by typical culturing conditions used for fungi organism. Bubble breakage frequency and coalescence rate were simulated using Luo - Colaloglou and Tavlarides models and PBM approaches, respectively. Simulated results from different shear rates due to non-newtonian behaviour are compared by analyzing its influences in bubble size and power input. Findings: A clear relationship between high levels of shear rates and small bubble sizes is found in this work. The later is also associated with the high values of kLa simulated (270 h-1) and compared to levels found at low shear rates (62 h-1). Application/Improvements: Impressed by these findings new design optimizations for non-newtonian bioprocessing applications would be improved using CFD.

• Autores: Niño López, Lilibeth; Peñuela Vásquez, Mariana; Gelves, Germán Ricardo
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2018
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/35487
• Acceso en línea: https://hdl.handle.net/10495/35487
• Palabra clave: Fluidos viscosos; Viscous fluid; Dinámica de fluidos; Fluid dynamics; non-Newtonian fluids; Fluidos no newtonianos; Biorreactores; Bioreactors; Biotecnología; Biotechnology; Anchor; Bubble coalescence; Sauter diameter; http://aims.fao.org/aos/agrovoc/c_6b709a96; http://aims.fao.org/aos/agrovoc/c_27469; http://aims.fao.org/aos/agrovoc/c_16165
• Rights: openAccess
• License: http://creativecommons.org/licenses/by/2.5/co/