Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition

ABSTRACT: Alcohol dependence is a common, complex and debilitating disorder with genetic and environmental influences. Here we show that alcohol consumption increases following mutations to the g-aminobutyric acidA receptor (GABAAR) b1 subunit gene (Gabrb1). Using N-ethyl-N-nitrosourea mutagenesis o...

Full description

Autores:

Martínez, Alonso
Anstee, Quentin M.
Knapp, Susanne
Maguire, Edward P.
Hosie, Alastair M.
Thomas, Philip
Mortensen, Martin
Bhome, Rohan
Walker, Sophie E.
Dixon, Claire I.
Ruparelia, Kush
Montagnese, Sara
Kuo, Yu-Ting
Herlihy, Amy
Bell, Jimmy D.
Robinson, Iain
Guerrini, Irene
McQuillin, Andrew
Fisher, Elizabeth M.C.
Ungless, Mark A.
Gurling, Hugh M.D.
Morgan, Marsha Y.
Brown, Steve D.M.
Stephens, David N.
Belelli, Delia
Lambert, Jeremy J.
Smart, Trevor G.
Thomas, Howard C.

Tipo de recurso:

Article of investigation

Fecha de publicación:

2024

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/43358

Acceso en línea:

https://hdl.handle.net/10495/43358

Palabra clave:

Consumo de Bebidas Alcohólicas
Alcohol Drinking
Trastornos Relacionados con Alcohol
Alcohol-Related Disorders
Genes Dominantes
Genes, Dominant
Células HEK293
HEK293 Cells
Ratones Endogámicos BALB C
Mice, Inbred BALB C
Ratones Endogámicos C3H
Mice, Inbred C3H
Núcleo Accumbens
Nucleus Accumbens
Mutación Puntual
Point Mutation
Receptores de GABA-A
Receptors, GABA-A
https://id.nlm.nih.gov/mesh/D000428
https://id.nlm.nih.gov/mesh/D019973
https://id.nlm.nih.gov/mesh/D005799
https://id.nlm.nih.gov/mesh/D057809
https://id.nlm.nih.gov/mesh/D008807
https://id.nlm.nih.gov/mesh/D008809
https://id.nlm.nih.gov/mesh/D009714
https://id.nlm.nih.gov/mesh/D017354
https://id.nlm.nih.gov/mesh/D011963

Rights

openAccess

License

http://creativecommons.org/licenses/by/2.5/co/