Characterization and structure prediction of the 5' untranslated region from Hepatitis C Virus Colombian isolates
ABSTRACT: The genome of the Hepatitis C Virus (HCV) is a single stranded positive sense RNA flanked by 5’ and 3’ untranslated regions (UTR). The 5’UTR has a relevant role in translation of the HCV polyprotein driven by the internal ribosome entry site (IRES). This structured región contains four dom...
- Autores:
-
Álvarez Cárdenas, Santiago
López Osorio, María Camila
Ochoa Deossa, Rodrigo Alonso
Navas Navas, María Cristina
- Tipo de recurso:
- http://purl.org/coar/resource_type/c_6670
- Fecha de publicación:
- 2022
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/37176
- Acceso en línea:
- https://hdl.handle.net/10495/37176
- Palabra clave:
- Hepacivirus
Hepatitis C
Regiones no Traducidas 5'
5' Untranslated Regions
Regiones no Traducidas 3'
3' Untranslated Regions
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-sa/4.0/
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Characterization and structure prediction of the 5' untranslated region from Hepatitis C Virus Colombian isolates |
| title |
Characterization and structure prediction of the 5' untranslated region from Hepatitis C Virus Colombian isolates |
| spellingShingle |
Characterization and structure prediction of the 5' untranslated region from Hepatitis C Virus Colombian isolates Hepacivirus Hepatitis C Regiones no Traducidas 5' 5' Untranslated Regions Regiones no Traducidas 3' 3' Untranslated Regions |
| title_short |
Characterization and structure prediction of the 5' untranslated region from Hepatitis C Virus Colombian isolates |
| title_full |
Characterization and structure prediction of the 5' untranslated region from Hepatitis C Virus Colombian isolates |
| title_fullStr |
Characterization and structure prediction of the 5' untranslated region from Hepatitis C Virus Colombian isolates |
| title_full_unstemmed |
Characterization and structure prediction of the 5' untranslated region from Hepatitis C Virus Colombian isolates |
| title_sort |
Characterization and structure prediction of the 5' untranslated region from Hepatitis C Virus Colombian isolates |
| dc.creator.fl_str_mv |
Álvarez Cárdenas, Santiago López Osorio, María Camila Ochoa Deossa, Rodrigo Alonso Navas Navas, María Cristina |
| dc.contributor.author.none.fl_str_mv |
Álvarez Cárdenas, Santiago López Osorio, María Camila Ochoa Deossa, Rodrigo Alonso Navas Navas, María Cristina |
| dc.contributor.conferencename.spa.fl_str_mv |
Annual meeting of American Society for Virology (41 : Del 16 al 20 de julio de 2022, University of Wisconsin, Madison, Estados Unidos) |
| dc.contributor.researchgroup.spa.fl_str_mv |
Grupo de Gastrohepatología Grupo Tandem en Nano-bio-física |
| dc.subject.decs.none.fl_str_mv |
Hepacivirus Hepatitis C Regiones no Traducidas 5' 5' Untranslated Regions Regiones no Traducidas 3' 3' Untranslated Regions |
| topic |
Hepacivirus Hepatitis C Regiones no Traducidas 5' 5' Untranslated Regions Regiones no Traducidas 3' 3' Untranslated Regions |
| description |
ABSTRACT: The genome of the Hepatitis C Virus (HCV) is a single stranded positive sense RNA flanked by 5’ and 3’ untranslated regions (UTR). The 5’UTR has a relevant role in translation of the HCV polyprotein driven by the internal ribosome entry site (IRES). This structured región contains four domains (DI-DIV) from which DII and DIII have the main role in the interaction to the ribosome, and therefore for initiation of translation. Furthermore, DII presents two subdomains (basal DIIa, and apical DIIb) while DIII consists of 6 stem-loops (DIIIabcdef). |
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2022 |
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2022 |
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2023-11-06T20:41:36Z |
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2023-11-06T20:41:36Z |
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https://hdl.handle.net/10495/37176 |
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eng |
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eng |
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2022-07-16/2022-07-20 |
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University of Wisconsin, Madison, Estados Unidos |
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41th annual meeting of American Society for Virology |
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Álvarez Cárdenas, SantiagoLópez Osorio, María CamilaOchoa Deossa, Rodrigo AlonsoNavas Navas, María CristinaAnnual meeting of American Society for Virology (41 : Del 16 al 20 de julio de 2022, University of Wisconsin, Madison, Estados Unidos)Grupo de GastrohepatologíaGrupo Tandem en Nano-bio-física2023-11-06T20:41:36Z2023-11-06T20:41:36Z2022https://hdl.handle.net/10495/37176ABSTRACT: The genome of the Hepatitis C Virus (HCV) is a single stranded positive sense RNA flanked by 5’ and 3’ untranslated regions (UTR). The 5’UTR has a relevant role in translation of the HCV polyprotein driven by the internal ribosome entry site (IRES). This structured región contains four domains (DI-DIV) from which DII and DIII have the main role in the interaction to the ribosome, and therefore for initiation of translation. Furthermore, DII presents two subdomains (basal DIIa, and apical DIIb) while DIII consists of 6 stem-loops (DIIIabcdef).COL0024159COL0202529application/pdfenghttps://creativecommons.org/licenses/by-nc-sa/4.0/http://creativecommons.org/licenses/by-nc-sa/2.5/co/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Characterization and structure prediction of the 5' untranslated region from Hepatitis C Virus Colombian isolatesPóster de conferenciahttp://purl.org/coar/resource_type/c_6670http://purl.org/coar/resource_type/c_c94fhttps://purl.org/redcol/resource_type/EChttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/publishedVersionMadison, Estados UnidosHepacivirusHepatitis CRegiones no Traducidas 5'5' Untranslated RegionsRegiones no Traducidas 3'3' Untranslated Regions2022-07-16/2022-07-20University of Wisconsin, Madison, Estados Unidos41th annual meeting of American Society for VirologyPublicationORIGINALAlvarezSantiago_2022_Characterization_Structure_Prediction.pdfAlvarezSantiago_2022_Characterization_Structure_Prediction.pdfPóster de conferenciaapplication/pdf3387130https://bibliotecadigital.udea.edu.co/bitstreams/0ab4755d-49ba-4cfe-8262-ef0485e385e2/downloadfbe3d50fa470d07d4c4e7fb54175f011MD51trueAnonymousREADCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81051https://bibliotecadigital.udea.edu.co/bitstreams/dffefa67-7982-4472-9e13-a26f85446c43/downloade2060682c9c70d4d30c83c51448f4eedMD52falseAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstreams/db914051-9932-4218-8bc4-22ef47f220b9/download8a4605be74aa9ea9d79846c1fba20a33MD53falseAnonymousREADTEXTAlvarezSantiago_2022_Characterization_Structure_Prediction.pdf.txtAlvarezSantiago_2022_Characterization_Structure_Prediction.pdf.txtExtracted texttext/plain3121https://bibliotecadigital.udea.edu.co/bitstreams/12eb1deb-0117-48a6-94f6-c0884a432858/download3c2ade3391d54b5aa90ad02d024065daMD54falseAnonymousREADTHUMBNAILAlvarezSantiago_2022_Characterization_Structure_Prediction.pdf.jpgAlvarezSantiago_2022_Characterization_Structure_Prediction.pdf.jpgGenerated Thumbnailimage/jpeg21145https://bibliotecadigital.udea.edu.co/bitstreams/834b88e8-60b3-44d6-9d17-9130d2a75098/download2f7fc8f61067c9198c29ef21e3cf749dMD55falseAnonymousREAD10495/37176oai:bibliotecadigital.udea.edu.co:10495/371762025-03-27 00:03:45.535https://creativecommons.org/licenses/by-nc-sa/4.0/open.accesshttps://bibliotecadigital.udea.edu.coRepositorio Institucional de la Universidad de Antioquiaaplicacionbibliotecadigitalbiblioteca@udea.edu.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 |