Characterization and structure prediction of the 5' untranslated region from Hepatitis C Virus Colombian isolates
ABSTRACT: The genome of the Hepatitis C Virus (HCV) is a single stranded positive sense RNA flanked by 5’ and 3’ untranslated regions (UTR). The 5’UTR has a relevant role in translation of the HCV polyprotein driven by the internal ribosome entry site (IRES). This structured región contains four dom...
- Autores:
-
Álvarez Cárdenas, Santiago
López Osorio, María Camila
Ochoa Deossa, Rodrigo Alonso
Navas Navas, María Cristina
- Tipo de recurso:
- http://purl.org/coar/resource_type/c_6670
- Fecha de publicación:
- 2022
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/37176
- Acceso en línea:
- https://hdl.handle.net/10495/37176
- Palabra clave:
- Hepacivirus
Hepatitis C
Regiones no Traducidas 5'
5' Untranslated Regions
Regiones no Traducidas 3'
3' Untranslated Regions
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-sa/4.0/
| Summary: | ABSTRACT: The genome of the Hepatitis C Virus (HCV) is a single stranded positive sense RNA flanked by 5’ and 3’ untranslated regions (UTR). The 5’UTR has a relevant role in translation of the HCV polyprotein driven by the internal ribosome entry site (IRES). This structured región contains four domains (DI-DIV) from which DII and DIII have the main role in the interaction to the ribosome, and therefore for initiation of translation. Furthermore, DII presents two subdomains (basal DIIa, and apical DIIb) while DIII consists of 6 stem-loops (DIIIabcdef). |
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