Neurogenesis and gliogenesis modulation in cerebral ischemia by CDK5 RNAi-based therapy
ABSTRACT: Cerebral ischemia is the third cause of death risk in Colombia and the first cause of physical disability worldwide. Different studies on the silencing of the cyclin-dependent kinase 5 (CDK5) have shown that reducing its activity is beneficial in ischemic contexts. However, its effect on n...
- Autores:
-
Cardona Gómez, Gloria Patricia
Muñoz Manco, Juan Ignacio
Gutiérrez Vargas, Johanna Andrea
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2018
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/36534
- Acceso en línea:
- https://hdl.handle.net/10495/36534
- Palabra clave:
- Isquemia Encefálica
Brain Ischemia
Neurogénesis
Quinasa 5 Dependiente de la Ciclina
Cyclin-Dependent Kinase 5
Estenosis Carotídea
Carotid Stenosis
Momento de Replicación del ADN
Período de Replicação do DNA
Terapia Molecular Dirigida
Molecular Targeted Therapy
Ratas Wistar
Rats, Wistar
Interferencia de ARN
RNA Interference
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-nd/4.0/
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| dc.title.spa.fl_str_mv |
Neurogenesis and gliogenesis modulation in cerebral ischemia by CDK5 RNAi-based therapy |
| dc.title.translated.spa.fl_str_mv |
Modulación de la neurogénesis y la gliogénesis en la isquemia cerebral mediante una terapia basada en la interferencia de CDK5 |
| title |
Neurogenesis and gliogenesis modulation in cerebral ischemia by CDK5 RNAi-based therapy |
| spellingShingle |
Neurogenesis and gliogenesis modulation in cerebral ischemia by CDK5 RNAi-based therapy Isquemia Encefálica Brain Ischemia Neurogénesis Quinasa 5 Dependiente de la Ciclina Cyclin-Dependent Kinase 5 Estenosis Carotídea Carotid Stenosis Momento de Replicación del ADN Período de Replicação do DNA Terapia Molecular Dirigida Molecular Targeted Therapy Ratas Wistar Rats, Wistar Interferencia de ARN RNA Interference |
| title_short |
Neurogenesis and gliogenesis modulation in cerebral ischemia by CDK5 RNAi-based therapy |
| title_full |
Neurogenesis and gliogenesis modulation in cerebral ischemia by CDK5 RNAi-based therapy |
| title_fullStr |
Neurogenesis and gliogenesis modulation in cerebral ischemia by CDK5 RNAi-based therapy |
| title_full_unstemmed |
Neurogenesis and gliogenesis modulation in cerebral ischemia by CDK5 RNAi-based therapy |
| title_sort |
Neurogenesis and gliogenesis modulation in cerebral ischemia by CDK5 RNAi-based therapy |
| dc.creator.fl_str_mv |
Cardona Gómez, Gloria Patricia Muñoz Manco, Juan Ignacio Gutiérrez Vargas, Johanna Andrea |
| dc.contributor.author.none.fl_str_mv |
Cardona Gómez, Gloria Patricia Muñoz Manco, Juan Ignacio Gutiérrez Vargas, Johanna Andrea |
| dc.contributor.researchgroup.spa.fl_str_mv |
Grupo de Neurociencias de Antioquia |
| dc.subject.decs.none.fl_str_mv |
Isquemia Encefálica Brain Ischemia Neurogénesis Quinasa 5 Dependiente de la Ciclina Cyclin-Dependent Kinase 5 Estenosis Carotídea Carotid Stenosis Momento de Replicación del ADN Período de Replicação do DNA Terapia Molecular Dirigida Molecular Targeted Therapy Ratas Wistar Rats, Wistar Interferencia de ARN RNA Interference |
| topic |
Isquemia Encefálica Brain Ischemia Neurogénesis Quinasa 5 Dependiente de la Ciclina Cyclin-Dependent Kinase 5 Estenosis Carotídea Carotid Stenosis Momento de Replicación del ADN Período de Replicação do DNA Terapia Molecular Dirigida Molecular Targeted Therapy Ratas Wistar Rats, Wistar Interferencia de ARN RNA Interference |
| description |
ABSTRACT: Cerebral ischemia is the third cause of death risk in Colombia and the first cause of physical disability worldwide. Different studies on the silencing of the cyclin-dependent kinase 5 (CDK5) have shown that reducing its activity is beneficial in ischemic contexts. However, its effect on neural cell production after cerebral ischemia has not been well studied yet. |
| publishDate |
2018 |
| dc.date.issued.none.fl_str_mv |
2018 |
| dc.date.accessioned.none.fl_str_mv |
2023-09-04T15:42:13Z |
| dc.date.available.none.fl_str_mv |
2023-09-04T15:42:13Z |
| dc.type.spa.fl_str_mv |
Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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https://purl.org/redcol/resource_type/ART |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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Muñoz-Manco, J. I., Gutiérrez-Vargas, J. A., & Cardona-Gómez, G. P. (2018). Neurogenesis and gliogenesis modulation in cerebral ischemia by CDK5 RNAi-based therapy. Biomedica : revista del Instituto Nacional de Salud, 38(3), 388–397. https://doi.org/10.7705/biomedica.v38i4.3800 |
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0120-4157 |
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https://hdl.handle.net/10495/36534 |
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10.7705/biomedica.v38i4.3800 |
| dc.identifier.eissn.none.fl_str_mv |
2590-7379 |
| identifier_str_mv |
Muñoz-Manco, J. I., Gutiérrez-Vargas, J. A., & Cardona-Gómez, G. P. (2018). Neurogenesis and gliogenesis modulation in cerebral ischemia by CDK5 RNAi-based therapy. Biomedica : revista del Instituto Nacional de Salud, 38(3), 388–397. https://doi.org/10.7705/biomedica.v38i4.3800 0120-4157 10.7705/biomedica.v38i4.3800 2590-7379 |
| url |
https://hdl.handle.net/10495/36534 |
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eng |
| language |
eng |
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Biomédica |
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397 |
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3 |
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388 |
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38 |
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Biomédica |
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Instituto Nacional de Salud |
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Bogotá, Colombia |
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Universidad de Antioquia |
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Cardona Gómez, Gloria PatriciaMuñoz Manco, Juan IgnacioGutiérrez Vargas, Johanna AndreaGrupo de Neurociencias de Antioquia2023-09-04T15:42:13Z2023-09-04T15:42:13Z2018Muñoz-Manco, J. I., Gutiérrez-Vargas, J. A., & Cardona-Gómez, G. P. (2018). Neurogenesis and gliogenesis modulation in cerebral ischemia by CDK5 RNAi-based therapy. Biomedica : revista del Instituto Nacional de Salud, 38(3), 388–397. https://doi.org/10.7705/biomedica.v38i4.38000120-4157https://hdl.handle.net/10495/3653410.7705/biomedica.v38i4.38002590-7379ABSTRACT: Cerebral ischemia is the third cause of death risk in Colombia and the first cause of physical disability worldwide. Different studies on the silencing of the cyclin-dependent kinase 5 (CDK5) have shown that reducing its activity is beneficial in ischemic contexts. However, its effect on neural cell production after cerebral ischemia has not been well studied yet.RESUMEN: La isquemia cerebral es la tercera causa de riesgo de muerte en Colombia y la primera causa de discapacidad física en el mundo. En diversos estudios en los que se silenció la cinasa 5 dependiente de la ciclina (CDK5) se ha demostrado que la reducción de su actividad es beneficiosa frente a la isquemia. Sin embargo, su efecto sobre la neurogénesis después de la isquemia no se ha dilucidado suficientemente.Ministerio de Ciencia, Tecnología e InnovaciónCOL001074410application/pdfengInstituto Nacional de SaludBogotá, Colombiahttps://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/2.5/co/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Neurogenesis and gliogenesis modulation in cerebral ischemia by CDK5 RNAi-based therapyModulación de la neurogénesis y la gliogénesis en la isquemia cerebral mediante una terapia basada en la interferencia de CDK5Artículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionIsquemia EncefálicaBrain IschemiaNeurogénesisQuinasa 5 Dependiente de la CiclinaCyclin-Dependent Kinase 5Estenosis CarotídeaCarotid StenosisMomento de Replicación del ADNPeríodo de Replicação do DNATerapia Molecular DirigidaMolecular Targeted TherapyRatas WistarRats, WistarInterferencia de ARNRNA InterferenceBiomédica397338838Biomédicaproject 111554531400RoR: 048jthh02PublicationORIGINALCardonaGloria_2018_NeurogenesisGliogenesisModulation.pdfCardonaGloria_2018_NeurogenesisGliogenesisModulation.pdfArtículo de investigaciónapplication/pdf2550971https://bibliotecadigital.udea.edu.co/bitstreams/66f1382f-fee6-4968-99b1-96a30e79011b/download8a389e2080c32ee4ce944598e52f5512MD51trueAnonymousREADCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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