Gene expression study using real-time PCR identifies an NTR gene as a major marker of resistance to benznidazole in Trypanosoma cruzi

ABSTRACT: Background: Chagas disease is a neglected illness, with limited treatments, caused by the parasite Trypanosoma cruzi. Two drugs are prescribed to treat the disease, nifurtimox and benznidazole, which have been previously reported to have limited efficacy and the appearance of resistance by...

Full description

Autores:

Mejía Jaramillo, Ana María
Fernández García, Geysson Javier
Palacio Muñoz, Lina Marcela
Triana Chávez, Omar

Tipo de recurso:

Article of investigation

Fecha de publicación:

2011

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/23695

Acceso en línea:

http://hdl.handle.net/10495/23695

Palabra clave:

Trypanosoma cruzi
Nifurtimox
Resistencia a Medicamentos
Drug Resistance
Enfermedad de Chagas
Chagas disease
Fenotipo
Phenotypes
Benznidazol
Genes involucrados
http://aims.fao.org/aos/agrovoc/c_5776
https://id.nlm.nih.gov/mesh/D014349
https://id.nlm.nih.gov/mesh/D009547
https://id.nlm.nih.gov/mesh/D004351

Rights

openAccess

License

https://creativecommons.org/licenses/by/4.0/