La interleuquina-8 como molécula clave en el periodonto
ABSTRACT: Periodontal disease is the result of the interaction of periodontal pathogens and the immune response of the individual. Neutrophils are the first line of innate cellular defense in periodontal tissues and also important in the initial protection against pathogens. The chemokines especiall...
- Autores:
-
Medina Echeverry, María Eugenia
Patiño Grajales, Pablo Javier
Sierra, Luz Inés
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2005
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- spa
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/9160
- Acceso en línea:
- http://hdl.handle.net/10495/9160
- Palabra clave:
- Interleucina 8
Interleukin-8
Neutrófilos
Neutrophils
Bacterias patógenas
Pathogenic bacteria
Periodontitis
Periodontitis
Interleucinas
Interleukins
Enfermedades periodontales
Periodontal disease
Periodoncia
Periodontics
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-sa/2.5/co/
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La interleuquina-8 como molécula clave en el periodonto |
| title |
La interleuquina-8 como molécula clave en el periodonto |
| spellingShingle |
La interleuquina-8 como molécula clave en el periodonto Interleucina 8 Interleukin-8 Neutrófilos Neutrophils Bacterias patógenas Pathogenic bacteria Periodontitis Periodontitis Interleucinas Interleukins Enfermedades periodontales Periodontal disease Periodoncia Periodontics |
| title_short |
La interleuquina-8 como molécula clave en el periodonto |
| title_full |
La interleuquina-8 como molécula clave en el periodonto |
| title_fullStr |
La interleuquina-8 como molécula clave en el periodonto |
| title_full_unstemmed |
La interleuquina-8 como molécula clave en el periodonto |
| title_sort |
La interleuquina-8 como molécula clave en el periodonto |
| dc.creator.fl_str_mv |
Medina Echeverry, María Eugenia Patiño Grajales, Pablo Javier Sierra, Luz Inés |
| dc.contributor.author.none.fl_str_mv |
Medina Echeverry, María Eugenia Patiño Grajales, Pablo Javier Sierra, Luz Inés |
| dc.contributor.researchgroup.spa.fl_str_mv |
Inmunodeficiencias Primarias |
| dc.subject.none.fl_str_mv |
Interleucina 8 Interleukin-8 Neutrófilos Neutrophils Bacterias patógenas Pathogenic bacteria Periodontitis Periodontitis Interleucinas Interleukins Enfermedades periodontales Periodontal disease Periodoncia Periodontics |
| topic |
Interleucina 8 Interleukin-8 Neutrófilos Neutrophils Bacterias patógenas Pathogenic bacteria Periodontitis Periodontitis Interleucinas Interleukins Enfermedades periodontales Periodontal disease Periodoncia Periodontics |
| description |
ABSTRACT: Periodontal disease is the result of the interaction of periodontal pathogens and the immune response of the individual. Neutrophils are the first line of innate cellular defense in periodontal tissues and also important in the initial protection against pathogens. The chemokines especially the interleukin 8 (IL-8) are fundamental for the recruitment and activation of the neutrophils in the periodontal tissues. The bacteria stimulate the production of IL-8 in different cells, which are derivative of the periodontal tissues in vitro and in patients with periodontitis. Several mechanisms of intracellular signaling bring to the production of IL-8. Among the periodontal pathogens there are differences in the stimulus for the production of this cytokine: Fusobacterium sp, Actinobacillus actinomycetemcomitans, and some Treponemas always induce their production. Porphyromonas gingivalis and Treponema denticola also stimulate production, but they present mechanisms that can induce quick degradation of this cytokine. The proteases from Porphyromonas gingivalis and the presence of antibodies against the IL-8 can explain the variations in the level of this cytokine in patients with periodontitis and probably in the function of the neutrophils in different aggressive periodontitis. This article reviews the production of IL-8 by several cell populations, in periodontal tissues and crevicular fluids and its role as a clue molecule in immune and inflammatory response. |
| publishDate |
2005 |
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2005 |
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2018-03-02T19:14:17Z |
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2018-03-02T19:14:17Z |
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Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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https://purl.org/redcol/resource_type/ART |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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Medina M, Patiño P, Sierra L. La interleuquina-8 como molécula clave en el periodonto. Rev Fac Odontol Univ Antioq. 2005;16(1-2):115-124 |
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0121-246X |
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http://hdl.handle.net/10495/9160 |
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2145-7670 |
| identifier_str_mv |
Medina M, Patiño P, Sierra L. La interleuquina-8 como molécula clave en el periodonto. Rev Fac Odontol Univ Antioq. 2005;16(1-2):115-124 0121-246X 2145-7670 |
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spa |
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spa |
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Rev Fac Odontol Univ Antioq |
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124 |
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1-2 |
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115 |
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16 |
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Revista Facultad de Odontología Universidad de Antioquia |
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Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO) |
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Medina Echeverry, María EugeniaPatiño Grajales, Pablo JavierSierra, Luz InésInmunodeficiencias Primarias2018-03-02T19:14:17Z2018-03-02T19:14:17Z2005Medina M, Patiño P, Sierra L. La interleuquina-8 como molécula clave en el periodonto. Rev Fac Odontol Univ Antioq. 2005;16(1-2):115-1240121-246Xhttp://hdl.handle.net/10495/91602145-7670ABSTRACT: Periodontal disease is the result of the interaction of periodontal pathogens and the immune response of the individual. Neutrophils are the first line of innate cellular defense in periodontal tissues and also important in the initial protection against pathogens. The chemokines especially the interleukin 8 (IL-8) are fundamental for the recruitment and activation of the neutrophils in the periodontal tissues. The bacteria stimulate the production of IL-8 in different cells, which are derivative of the periodontal tissues in vitro and in patients with periodontitis. Several mechanisms of intracellular signaling bring to the production of IL-8. Among the periodontal pathogens there are differences in the stimulus for the production of this cytokine: Fusobacterium sp, Actinobacillus actinomycetemcomitans, and some Treponemas always induce their production. Porphyromonas gingivalis and Treponema denticola also stimulate production, but they present mechanisms that can induce quick degradation of this cytokine. The proteases from Porphyromonas gingivalis and the presence of antibodies against the IL-8 can explain the variations in the level of this cytokine in patients with periodontitis and probably in the function of the neutrophils in different aggressive periodontitis. This article reviews the production of IL-8 by several cell populations, in periodontal tissues and crevicular fluids and its role as a clue molecule in immune and inflammatory response.RESUMEN: Las periodontitis son el resultado de la interacción de microorganismos periodontopáticos y la respuesta inmune del individuo. Los polimorfonucleares neutrófilos (PMN) son la primera línea de defensa celular innata en tejidos periodontales y su funcionamiento es importante en la protección inicial contra las bacterias periodontopáticas. Las quimiocinas, en especial la interleuquina 8 (IL-8), son fundamentales para el reclutamiento y activación de los PMN en los tejidos periodontales. Las bacterias estimulan la producción de IL- 8 en diferentes células derivadas de los tejidos periodontales in vitro y en pacientes con periodontitis. El estímulo bacteriano puede activar varios mecanismos de señalización intracelular, sin embargo, entre las bacterias periodontopáticas hay diferencias en el estímulo que induce la producción de esta citocina: Fusobacterium (Fn) sp, Actinobacillus actinomycetemcomitans (Aa), y algunos Treponemas siempre inducen su producción. Porphyromonas gingivalis (Pg) y Treponema denticola (Td) aunque estimulan producción, presentan mecanismos que pueden llevar a la degradación rápida de esta citocina. La demostración de proteasas de Pg y el hallazgo de anticuerpos contra la IL-8 pueden explicar las variaciones en los pacientes con periodontitis y probablemente en el funcionamiento de los PMN en diferentes periodontitis agresivas. En el presente artículo revisamos las respuestas de poblaciones celulares productoras de IL-8, en tejidos periodontales y fluido crevicular de pacientes con periodontitis y su papel como molécula clave en la defensa.COL0012426application/pdfspaUniversidad de Antioquia, Facultad de OdontologíaMedellín, Colombiahttps://creativecommons.org/licenses/by-nc-sa/2.5/co/https://creativecommons.org/licenses/by-nc-sa/4.0/Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Interleucina 8Interleukin-8NeutrófilosNeutrophilsBacterias patógenasPathogenic bacteriaPeriodontitisPeriodontitisInterleucinasInterleukinsEnfermedades periodontalesPeriodontal diseasePeriodonciaPeriodonticsLa interleuquina-8 como molécula clave en el periodontoArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRev Fac Odontol Univ Antioq1241-211516Revista Facultad de Odontología Universidad de AntioquiaPublicationORIGINALMedinaMaria_2005_Interleuquina8MoleculaPeriodonto.pdfMedinaMaria_2005_Interleuquina8MoleculaPeriodonto.pdfArtículo de investigaciónapplication/pdf2215144https://bibliotecadigital.udea.edu.co/bitstreams/61325e9e-6b28-42bd-b395-efc4fd7072c7/downloadb42c889f792018b3fe02c6aebc6e90a3MD51trueAnonymousREADCC-LICENSElicense_urllicense_urltext/plain; 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