The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris
ABSTRACT: The LUFS domain (LUG/LUH, Flo8, single-strand DNA-binding protein [SSBP]) is a well-conserved and apparently ancient region found in diverse proteins and taxa. This domain, which has as its most obvious structural feature a series of three helices, has been identified in transcriptional re...
- Autores:
-
Misas Rivas, Elizabeth
McEwen Ochoa, Juan Guillermo
Escandón, Patricia
Clay, Oliver
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2019
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/45052
- Acceso en línea:
- https://hdl.handle.net/10495/45052
- Palabra clave:
- Secuencia de Aminoácidos
Amino Acid Sequence
Anfotericina B
Amphotericin B
Antifúngicos
Antifungal Agents
Candida
Proteínas de Unión al ADN
DNA-Binding Proteins
Farmacorresistencia Fúngica
Drug Resistance, Fungal
Pruebas de Sensibilidad Microbiana
Microbial Sensitivity Tests
Modelos Moleculares
Models, Molecular
Alineación de Secuencia
Sequence Alignment
https://id.nlm.nih.gov/mesh/D000595
https://id.nlm.nih.gov/mesh/D000666
https://id.nlm.nih.gov/mesh/D000935
https://id.nlm.nih.gov/mesh/D002175
https://id.nlm.nih.gov/mesh/D004268
https://id.nlm.nih.gov/mesh/D025141
https://id.nlm.nih.gov/mesh/D008826
https://id.nlm.nih.gov/mesh/D008958
https://id.nlm.nih.gov/mesh/D016415
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-nd/4.0/
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The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris |
| title |
The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris |
| spellingShingle |
The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris Secuencia de Aminoácidos Amino Acid Sequence Anfotericina B Amphotericin B Antifúngicos Antifungal Agents Candida Proteínas de Unión al ADN DNA-Binding Proteins Farmacorresistencia Fúngica Drug Resistance, Fungal Pruebas de Sensibilidad Microbiana Microbial Sensitivity Tests Modelos Moleculares Models, Molecular Alineación de Secuencia Sequence Alignment https://id.nlm.nih.gov/mesh/D000595 https://id.nlm.nih.gov/mesh/D000666 https://id.nlm.nih.gov/mesh/D000935 https://id.nlm.nih.gov/mesh/D002175 https://id.nlm.nih.gov/mesh/D004268 https://id.nlm.nih.gov/mesh/D025141 https://id.nlm.nih.gov/mesh/D008826 https://id.nlm.nih.gov/mesh/D008958 https://id.nlm.nih.gov/mesh/D016415 |
| title_short |
The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris |
| title_full |
The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris |
| title_fullStr |
The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris |
| title_full_unstemmed |
The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris |
| title_sort |
The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris |
| dc.creator.fl_str_mv |
Misas Rivas, Elizabeth McEwen Ochoa, Juan Guillermo Escandón, Patricia Clay, Oliver |
| dc.contributor.author.none.fl_str_mv |
Misas Rivas, Elizabeth McEwen Ochoa, Juan Guillermo Escandón, Patricia Clay, Oliver |
| dc.contributor.researchgroup.spa.fl_str_mv |
Biología Celular y Molecular CIB U. de A. U. del Rosario Micología Médica |
| dc.subject.decs.none.fl_str_mv |
Secuencia de Aminoácidos Amino Acid Sequence Anfotericina B Amphotericin B Antifúngicos Antifungal Agents Candida Proteínas de Unión al ADN DNA-Binding Proteins Farmacorresistencia Fúngica Drug Resistance, Fungal Pruebas de Sensibilidad Microbiana Microbial Sensitivity Tests Modelos Moleculares Models, Molecular Alineación de Secuencia Sequence Alignment |
| topic |
Secuencia de Aminoácidos Amino Acid Sequence Anfotericina B Amphotericin B Antifúngicos Antifungal Agents Candida Proteínas de Unión al ADN DNA-Binding Proteins Farmacorresistencia Fúngica Drug Resistance, Fungal Pruebas de Sensibilidad Microbiana Microbial Sensitivity Tests Modelos Moleculares Models, Molecular Alineación de Secuencia Sequence Alignment https://id.nlm.nih.gov/mesh/D000595 https://id.nlm.nih.gov/mesh/D000666 https://id.nlm.nih.gov/mesh/D000935 https://id.nlm.nih.gov/mesh/D002175 https://id.nlm.nih.gov/mesh/D004268 https://id.nlm.nih.gov/mesh/D025141 https://id.nlm.nih.gov/mesh/D008826 https://id.nlm.nih.gov/mesh/D008958 https://id.nlm.nih.gov/mesh/D016415 |
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https://id.nlm.nih.gov/mesh/D000595 https://id.nlm.nih.gov/mesh/D000666 https://id.nlm.nih.gov/mesh/D000935 https://id.nlm.nih.gov/mesh/D002175 https://id.nlm.nih.gov/mesh/D004268 https://id.nlm.nih.gov/mesh/D025141 https://id.nlm.nih.gov/mesh/D008826 https://id.nlm.nih.gov/mesh/D008958 https://id.nlm.nih.gov/mesh/D016415 |
| description |
ABSTRACT: The LUFS domain (LUG/LUH, Flo8, single-strand DNA-binding protein [SSBP]) is a well-conserved and apparently ancient region found in diverse proteins and taxa. This domain, which has as its most obvious structural feature a series of three helices, has been identified in transcriptional regulator proteins of animals, plants, and fungi. Recently, in these pages (Wang et al., Protein Sci., 2019, 28:788-793), the first crystal structure of a LUFS domain was reported, for the human SSBP2, a transcriptional repressor. We briefly address how the new insights into LUFS structures might contribute to a better understanding of an important transcriptional activator of yeasts that contains the LUFS domain, Flo8, and consider how a focus on the LUFS domain and its variation could help us to understand etiologies of drug resistance in a recently emerged pathogenic fungus, Candida auris. |
| publishDate |
2019 |
| dc.date.issued.none.fl_str_mv |
2019 |
| dc.date.accessioned.none.fl_str_mv |
2025-02-19T21:42:04Z |
| dc.date.available.none.fl_str_mv |
2025-02-19T21:42:04Z |
| dc.type.spa.fl_str_mv |
Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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Misas E, Escandón P, McEwen JG, Clay OK. The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris. Protein Sci. 2019 Nov;28(11):2024-2029. doi: 10.1002/pro.3727. |
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0961-8368 |
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https://hdl.handle.net/10495/45052 |
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10.1002/pro.3727 |
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1469-896X |
| identifier_str_mv |
Misas E, Escandón P, McEwen JG, Clay OK. The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris. Protein Sci. 2019 Nov;28(11):2024-2029. doi: 10.1002/pro.3727. 0961-8368 10.1002/pro.3727 1469-896X |
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https://hdl.handle.net/10495/45052 |
| dc.language.iso.spa.fl_str_mv |
eng |
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eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Protein. Sci. |
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2029 |
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11 |
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2024 |
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28 |
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Protein Science |
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6 páginas |
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Misas Rivas, ElizabethMcEwen Ochoa, Juan GuillermoEscandón, PatriciaClay, OliverBiología Celular y Molecular CIB U. de A. U. del RosarioMicología Médica2025-02-19T21:42:04Z2025-02-19T21:42:04Z2019Misas E, Escandón P, McEwen JG, Clay OK. The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris. Protein Sci. 2019 Nov;28(11):2024-2029. doi: 10.1002/pro.3727.0961-8368https://hdl.handle.net/10495/4505210.1002/pro.37271469-896XABSTRACT: The LUFS domain (LUG/LUH, Flo8, single-strand DNA-binding protein [SSBP]) is a well-conserved and apparently ancient region found in diverse proteins and taxa. This domain, which has as its most obvious structural feature a series of three helices, has been identified in transcriptional regulator proteins of animals, plants, and fungi. Recently, in these pages (Wang et al., Protein Sci., 2019, 28:788-793), the first crystal structure of a LUFS domain was reported, for the human SSBP2, a transcriptional repressor. We briefly address how the new insights into LUFS structures might contribute to a better understanding of an important transcriptional activator of yeasts that contains the LUFS domain, Flo8, and consider how a focus on the LUFS domain and its variation could help us to understand etiologies of drug resistance in a recently emerged pathogenic fungus, Candida auris.Universidad de Antioquia. Vicerrectoría de investigación. Comité para el Desarrollo de la Investigación - CODIColombia. Ministerio de Ciencia, Tecnología e Innovación - MinCienciasCOL0000962COL00420696 páginasapplication/pdfengWileyWoodbury, Estados Unidoshttps://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/2.5/co/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida aurisArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionSecuencia de AminoácidosAmino Acid SequenceAnfotericina BAmphotericin BAntifúngicosAntifungal AgentsCandidaProteínas de Unión al ADNDNA-Binding ProteinsFarmacorresistencia FúngicaDrug Resistance, FungalPruebas de Sensibilidad MicrobianaMicrobial Sensitivity TestsModelos MolecularesModels, MolecularAlineación de SecuenciaSequence Alignmenthttps://id.nlm.nih.gov/mesh/D000595https://id.nlm.nih.gov/mesh/D000666https://id.nlm.nih.gov/mesh/D000935https://id.nlm.nih.gov/mesh/D002175https://id.nlm.nih.gov/mesh/D004268https://id.nlm.nih.gov/mesh/D025141https://id.nlm.nih.gov/mesh/D008826https://id.nlm.nih.gov/mesh/D008958https://id.nlm.nih.gov/mesh/D016415Protein. 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