Fungal Vaccine Development: State of the Art and Perspectives Using Immunoinformatics
ABSTRACT: Fungal infections represent a serious global health problem, causing damage to health and the economy on the scale of millions. Although vaccines are the most effective therapeutic approach used to combat infectious agents, at the moment, no fungal vaccine has been approved for use in huma...
- Autores:
-
Hernández Ruiz, Orville
de Almeida Soares, Célia Maria
Borges, Clayton Luiz
Dias, Fátima Ribeiro
Elias Moreira, André Luís
Mattos, Karine
Milhomem Cruz Leite, Vanessa Rafaela
Morais Inácio, Moisés
O’Hara Souza Silva, Lana
Schneider Weber, Simone
Venturini, James
- Tipo de recurso:
- Review article
- Fecha de publicación:
- 2023
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/41224
- Acceso en línea:
- https://hdl.handle.net/10495/41224
https://www.mdpi.com/journal/jof
- Palabra clave:
- Biología Computacional
Computational Biology
Hongos
Fungi
Vacunas
Vaccines
Enfermedades Desatendidas
Neglected Diseases
Micosis
Mycoses
https://id.nlm.nih.gov/mesh/D019295
https://id.nlm.nih.gov/mesh/D005658
https://id.nlm.nih.gov/mesh/D014612
https://id.nlm.nih.gov/mesh/D058069
https://id.nlm.nih.gov/mesh/D009181
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by/2.5/co/
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Fungal Vaccine Development: State of the Art and Perspectives Using Immunoinformatics |
| title |
Fungal Vaccine Development: State of the Art and Perspectives Using Immunoinformatics |
| spellingShingle |
Fungal Vaccine Development: State of the Art and Perspectives Using Immunoinformatics Biología Computacional Computational Biology Hongos Fungi Vacunas Vaccines Enfermedades Desatendidas Neglected Diseases Micosis Mycoses https://id.nlm.nih.gov/mesh/D019295 https://id.nlm.nih.gov/mesh/D005658 https://id.nlm.nih.gov/mesh/D014612 https://id.nlm.nih.gov/mesh/D058069 https://id.nlm.nih.gov/mesh/D009181 |
| title_short |
Fungal Vaccine Development: State of the Art and Perspectives Using Immunoinformatics |
| title_full |
Fungal Vaccine Development: State of the Art and Perspectives Using Immunoinformatics |
| title_fullStr |
Fungal Vaccine Development: State of the Art and Perspectives Using Immunoinformatics |
| title_full_unstemmed |
Fungal Vaccine Development: State of the Art and Perspectives Using Immunoinformatics |
| title_sort |
Fungal Vaccine Development: State of the Art and Perspectives Using Immunoinformatics |
| dc.creator.fl_str_mv |
Hernández Ruiz, Orville de Almeida Soares, Célia Maria Borges, Clayton Luiz Dias, Fátima Ribeiro Elias Moreira, André Luís Mattos, Karine Milhomem Cruz Leite, Vanessa Rafaela Morais Inácio, Moisés O’Hara Souza Silva, Lana Schneider Weber, Simone Venturini, James |
| dc.contributor.author.none.fl_str_mv |
Hernández Ruiz, Orville de Almeida Soares, Célia Maria Borges, Clayton Luiz Dias, Fátima Ribeiro Elias Moreira, André Luís Mattos, Karine Milhomem Cruz Leite, Vanessa Rafaela Morais Inácio, Moisés O’Hara Souza Silva, Lana Schneider Weber, Simone Venturini, James |
| dc.contributor.researchgroup.spa.fl_str_mv |
Biología Celular y Molecular CIB U. de A. U. del Rosario Grupo de Investigación en Microbiología Básica y Aplicada-Microba |
| dc.subject.decs.none.fl_str_mv |
Biología Computacional Computational Biology Hongos Fungi Vacunas Vaccines Enfermedades Desatendidas Neglected Diseases Micosis Mycoses |
| topic |
Biología Computacional Computational Biology Hongos Fungi Vacunas Vaccines Enfermedades Desatendidas Neglected Diseases Micosis Mycoses https://id.nlm.nih.gov/mesh/D019295 https://id.nlm.nih.gov/mesh/D005658 https://id.nlm.nih.gov/mesh/D014612 https://id.nlm.nih.gov/mesh/D058069 https://id.nlm.nih.gov/mesh/D009181 |
| dc.subject.meshuri.none.fl_str_mv |
https://id.nlm.nih.gov/mesh/D019295 https://id.nlm.nih.gov/mesh/D005658 https://id.nlm.nih.gov/mesh/D014612 https://id.nlm.nih.gov/mesh/D058069 https://id.nlm.nih.gov/mesh/D009181 |
| description |
ABSTRACT: Fungal infections represent a serious global health problem, causing damage to health and the economy on the scale of millions. Although vaccines are the most effective therapeutic approach used to combat infectious agents, at the moment, no fungal vaccine has been approved for use in humans. However, the scientific community has been working hard to overcome this challenge. In this sense, we aim to describe here an update on the development of fungal vaccines and the progress of methodological and experimental immunotherapies against fungal infections. In addition, advances in immunoinformatic tools are described as an important aid by which to overcome the difficulty of achieving success in fungal vaccine development. In silico approaches are great options for the most important and difficult questions regarding the attainment of an efficient fungal vaccine. Here, we suggest how bioinformatic tools could contribute, considering the main challenges, to an effective fungal vaccine. |
| publishDate |
2023 |
| dc.date.issued.none.fl_str_mv |
2023 |
| dc.date.accessioned.none.fl_str_mv |
2024-08-18T19:14:19Z |
| dc.date.available.none.fl_str_mv |
2024-08-18T19:14:19Z |
| dc.type.spa.fl_str_mv |
Artículo de revisión |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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| dc.identifier.citation.spa.fl_str_mv |
Inácio MM, Moreira ALE, Cruz-Leite VRM, Mattos K, Silva LOS, Venturini J, Ruiz OH, Ribeiro-Dias F, Weber SS, Soares CMA, Borges CL. Fungal Vaccine Development: State of the Art and Perspectives Using Immunoinformatics. J Fungi (Basel). 2023 May 31;9(6):633. doi: 10.3390/jof9060633. |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/10495/41224 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/jof9060633 |
| dc.identifier.eissn.none.fl_str_mv |
2309-608X |
| dc.identifier.url.spa.fl_str_mv |
https://www.mdpi.com/journal/jof |
| identifier_str_mv |
Inácio MM, Moreira ALE, Cruz-Leite VRM, Mattos K, Silva LOS, Venturini J, Ruiz OH, Ribeiro-Dias F, Weber SS, Soares CMA, Borges CL. Fungal Vaccine Development: State of the Art and Perspectives Using Immunoinformatics. J Fungi (Basel). 2023 May 31;9(6):633. doi: 10.3390/jof9060633. 10.3390/jof9060633 2309-608X |
| url |
https://hdl.handle.net/10495/41224 https://www.mdpi.com/journal/jof |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
J. Fungi. |
| dc.relation.citationendpage.spa.fl_str_mv |
35 |
| dc.relation.citationissue.spa.fl_str_mv |
6 |
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1 |
| dc.relation.citationvolume.spa.fl_str_mv |
9 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Journal of Fungi |
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35 páginas |
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MDPI |
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Hernández Ruiz, Orvillede Almeida Soares, Célia MariaBorges, Clayton LuizDias, Fátima RibeiroElias Moreira, André LuísMattos, KarineMilhomem Cruz Leite, Vanessa RafaelaMorais Inácio, MoisésO’Hara Souza Silva, LanaSchneider Weber, SimoneVenturini, JamesBiología Celular y Molecular CIB U. de A. U. del RosarioGrupo de Investigación en Microbiología Básica y Aplicada-Microba2024-08-18T19:14:19Z2024-08-18T19:14:19Z2023Inácio MM, Moreira ALE, Cruz-Leite VRM, Mattos K, Silva LOS, Venturini J, Ruiz OH, Ribeiro-Dias F, Weber SS, Soares CMA, Borges CL. Fungal Vaccine Development: State of the Art and Perspectives Using Immunoinformatics. J Fungi (Basel). 2023 May 31;9(6):633. doi: 10.3390/jof9060633.https://hdl.handle.net/10495/4122410.3390/jof90606332309-608Xhttps://www.mdpi.com/journal/jofABSTRACT: Fungal infections represent a serious global health problem, causing damage to health and the economy on the scale of millions. Although vaccines are the most effective therapeutic approach used to combat infectious agents, at the moment, no fungal vaccine has been approved for use in humans. However, the scientific community has been working hard to overcome this challenge. In this sense, we aim to describe here an update on the development of fungal vaccines and the progress of methodological and experimental immunotherapies against fungal infections. In addition, advances in immunoinformatic tools are described as an important aid by which to overcome the difficulty of achieving success in fungal vaccine development. In silico approaches are great options for the most important and difficult questions regarding the attainment of an efficient fungal vaccine. Here, we suggest how bioinformatic tools could contribute, considering the main challenges, to an effective fungal vaccine.Conselho Nacional de Desenvolvimento Científico e TecnológicoInstitutos Nacionais de Ciência e TecnologiaFundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do SulCoordenação de Aperfeicoamento de Pessoal de Nível SuperiorCOL0000963COL012613135 páginasapplication/pdfengMDPIBasilea, Suizahttp://creativecommons.org/licenses/by/2.5/co/https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Fungal Vaccine Development: State of the Art and Perspectives Using ImmunoinformaticsArtículo de revisiónhttp://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTREVhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionBiología ComputacionalComputational BiologyHongosFungiVacunasVaccinesEnfermedades DesatendidasNeglected DiseasesMicosisMycoseshttps://id.nlm.nih.gov/mesh/D019295https://id.nlm.nih.gov/mesh/D005658https://id.nlm.nih.gov/mesh/D014612https://id.nlm.nih.gov/mesh/D058069https://id.nlm.nih.gov/mesh/D009181J. Fungi.35619Journal of FungiEdital Universal-CNPq- 408042/2021-4FUNDECT/DECIT-MS/CNPq/SES No. 03/2016-PPSUS-MS, PPSUS/FUNDECT No. 08/2020CAPES 001CAPES 88882.458447/2019-01RoR:03swz6y49RoR:045ydbe97RoR:05jtrt935RoR:00x0ma614PublicationCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8927https://bibliotecadigital.udea.edu.co/bitstreams/4fcd0ab4-dd36-4101-b858-34e5983bf90d/download1646d1f6b96dbbbc38035efc9239ac9cMD52falseAnonymousREADORIGINALRuizHernandezOrville_2023_Bioinformatic_Vaccine_Fungi.pdfRuizHernandezOrville_2023_Bioinformatic_Vaccine_Fungi.pdfArtículo de revisiónapplication/pdf1849123https://bibliotecadigital.udea.edu.co/bitstreams/cea76397-932f-4a0d-b22e-bf21a254136d/downloade12243103650927b7fae43d975f73b6eMD51trueAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstreams/b0da3a5a-d353-406a-b00f-8216d956bdc8/download8a4605be74aa9ea9d79846c1fba20a33MD53falseAnonymousREADTEXTRuizHernandezOrville_2023_Bioinformatic_Vaccine_Fungi.pdf.txtRuizHernandezOrville_2023_Bioinformatic_Vaccine_Fungi.pdf.txtExtracted texttext/plain100281https://bibliotecadigital.udea.edu.co/bitstreams/c527fa4a-80b7-4a64-af36-08bd2636b708/download43547ceb03a5b218be3dbc296220b9baMD54falseAnonymousREADTHUMBNAILRuizHernandezOrville_2023_Bioinformatic_Vaccine_Fungi.pdf.jpgRuizHernandezOrville_2023_Bioinformatic_Vaccine_Fungi.pdf.jpgGenerated Thumbnailimage/jpeg15489https://bibliotecadigital.udea.edu.co/bitstreams/b82a69bd-0c92-454f-8b9d-6a3b58297fcc/download26556721322acc9c71577a83506fbef8MD55falseAnonymousREAD10495/41224oai:bibliotecadigital.udea.edu.co:10495/412242025-03-27 01:13:44.209http://creativecommons.org/licenses/by/2.5/co/open.accesshttps://bibliotecadigital.udea.edu.coRepositorio Institucional de la Universidad de Antioquiaaplicacionbibliotecadigitalbiblioteca@udea.edu.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 |