Tuberculin skin test and CD4+/CD8+ T cell counts in adults infected with the human inmunodeficiency virus in Medellin, Colombia

ABSTRACT: To evaluate the effect of BCG vaccination and T lymphocyte subpopulations on the reactivity to the tuberculin skin test, 113 asymptomatic HIV+ individuals were tuberculin tested by intradermal injection of 5TU of purified protein derivative and the levels of circulating lymphocyte (CD3, CD4 and CD8) subpopulations determined by indirect immunofluorescence. Ninety-two percent of the subjects included in the study were males. The mean age of the group was 32.1 +/- 7.4 years. Sixty-two percent presented a BCG scar. However, only 22% exhibited positive tuberculin reactions (> or = 5 mm) irrespective of the presence of the BCG scar. Tuberculin positive individuals exhibited higher CD4+ cell counts (p = 0.004) and CD4+/CD8+ ratios (p = 0.006) than tuberculin negative (< 5 mm) HIV+ individuals. The number of individuals with positive tuberculin reactions was significantly higher in subjects with more than 500 CD4+ lymphocytes/microliter (p = 0.02) or CD4+/CD8+ ratios > or = 1.12 (p = 0.002). These results suggest that a prior BCG vaccination does not influence the reactivity to the tuberculin skin test in HIV+ asymptomatic individuals and that the number of CD4+ lymphocytes and the CD4+/ CD8+ ratio positively correlate with the tuberculin reactivity.

• Autores: Rodríguez Ospina, Jaime Iván; Arias Pineda, Mauricio Alberto; París Ángel, Sara Claudia; Arbeláez Montoya, María Patricia; Betancur, Julián; García Moreno, Luis Fernando
• Tipo de recurso: Article of investigation
• Fecha de publicación: 1997
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/38754
• Acceso en línea: https://hdl.handle.net/10495/38754
• Palabra clave: Vacuna BCG; BCG Vaccine; Recuento de Linfocito CD4; CD4 Lymphocyte Count; Relación CD4-CD8; CD4-CD8 Ratio; Colombia - epidemiología; Colombia - epidemiology; Estudios de Seguimiento; Follow-Up Studies; Infecciones por VIH; HIV Infections; Prueba de Tuberculina; Tuberculin Test; https://id.nlm.nih.gov/mesh/D001500; https://id.nlm.nih.gov/mesh/D018791; https://id.nlm.nih.gov/mesh/D016516; https://id.nlm.nih.gov/mesh/D003105; https://id.nlm.nih.gov/mesh/D005500; https://id.nlm.nih.gov/mesh/D015658; https://id.nlm.nih.gov/mesh/D014374
• Rights: openAccess
• License: https://creativecommons.org/licenses/by/4.0/