Frequency of CYP3A5 Genetic Polymorphisms and Tacrolimus Pharmacokinetics in Pediatric Liver Transplantation
ABSTRACT: The evidence available in the pediatric population is limited for making clinical decisions regarding the optimization of tacrolimus (TAC) in pharmacotherapy. The objective of this study was to estimate the frequency of CYP3A5 genetic polymorphisms and their relationship with tacrolimus re...
- Autores:
-
Buendía Rodríguez, Jefferson Antonio
Halac, Esteban
Bosaleh, Andrea
García de Dávila, María Teresa
Imvertasa, Óscar César
Bramuglia, Guillermo Federico
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/44827
- Acceso en línea:
- https://hdl.handle.net/10495/44827
- Palabra clave:
- Tacrolimus
Trasplante de Hígado
Liver Transplantation
Farmacocinética
Pharmacokinetics
Polimorfismo Genético
Polymorphism, Genetic
Citocromo P-450 CYP3A
Cytochrome P-450 CYP3A
https://id.nlm.nih.gov/mesh/D016559
https://id.nlm.nih.gov/mesh/D016031
https://id.nlm.nih.gov/mesh/D010599
https://id.nlm.nih.gov/mesh/D011110
https://id.nlm.nih.gov/mesh/D051544
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by/4.0/
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| dc.title.spa.fl_str_mv |
Frequency of CYP3A5 Genetic Polymorphisms and Tacrolimus Pharmacokinetics in Pediatric Liver Transplantation |
| title |
Frequency of CYP3A5 Genetic Polymorphisms and Tacrolimus Pharmacokinetics in Pediatric Liver Transplantation |
| spellingShingle |
Frequency of CYP3A5 Genetic Polymorphisms and Tacrolimus Pharmacokinetics in Pediatric Liver Transplantation Tacrolimus Trasplante de Hígado Liver Transplantation Farmacocinética Pharmacokinetics Polimorfismo Genético Polymorphism, Genetic Citocromo P-450 CYP3A Cytochrome P-450 CYP3A https://id.nlm.nih.gov/mesh/D016559 https://id.nlm.nih.gov/mesh/D016031 https://id.nlm.nih.gov/mesh/D010599 https://id.nlm.nih.gov/mesh/D011110 https://id.nlm.nih.gov/mesh/D051544 |
| title_short |
Frequency of CYP3A5 Genetic Polymorphisms and Tacrolimus Pharmacokinetics in Pediatric Liver Transplantation |
| title_full |
Frequency of CYP3A5 Genetic Polymorphisms and Tacrolimus Pharmacokinetics in Pediatric Liver Transplantation |
| title_fullStr |
Frequency of CYP3A5 Genetic Polymorphisms and Tacrolimus Pharmacokinetics in Pediatric Liver Transplantation |
| title_full_unstemmed |
Frequency of CYP3A5 Genetic Polymorphisms and Tacrolimus Pharmacokinetics in Pediatric Liver Transplantation |
| title_sort |
Frequency of CYP3A5 Genetic Polymorphisms and Tacrolimus Pharmacokinetics in Pediatric Liver Transplantation |
| dc.creator.fl_str_mv |
Buendía Rodríguez, Jefferson Antonio Halac, Esteban Bosaleh, Andrea García de Dávila, María Teresa Imvertasa, Óscar César Bramuglia, Guillermo Federico |
| dc.contributor.author.none.fl_str_mv |
Buendía Rodríguez, Jefferson Antonio Halac, Esteban Bosaleh, Andrea García de Dávila, María Teresa Imvertasa, Óscar César Bramuglia, Guillermo Federico |
| dc.contributor.researchgroup.spa.fl_str_mv |
Grupo de Investigación en Farmacología y Toxicología |
| dc.subject.decs.none.fl_str_mv |
Tacrolimus Trasplante de Hígado Liver Transplantation Farmacocinética Pharmacokinetics Polimorfismo Genético Polymorphism, Genetic Citocromo P-450 CYP3A Cytochrome P-450 CYP3A |
| topic |
Tacrolimus Trasplante de Hígado Liver Transplantation Farmacocinética Pharmacokinetics Polimorfismo Genético Polymorphism, Genetic Citocromo P-450 CYP3A Cytochrome P-450 CYP3A https://id.nlm.nih.gov/mesh/D016559 https://id.nlm.nih.gov/mesh/D016031 https://id.nlm.nih.gov/mesh/D010599 https://id.nlm.nih.gov/mesh/D011110 https://id.nlm.nih.gov/mesh/D051544 |
| dc.subject.meshuri.none.fl_str_mv |
https://id.nlm.nih.gov/mesh/D016559 https://id.nlm.nih.gov/mesh/D016031 https://id.nlm.nih.gov/mesh/D010599 https://id.nlm.nih.gov/mesh/D011110 https://id.nlm.nih.gov/mesh/D051544 |
| description |
ABSTRACT: The evidence available in the pediatric population is limited for making clinical decisions regarding the optimization of tacrolimus (TAC) in pharmacotherapy. The objective of this study was to estimate the frequency of CYP3A5 genetic polymorphisms and their relationship with tacrolimus requirements in the pediatric population. This was a longitudinal cohort study with a two-year follow-up of 77 patients under 18 years old who underwent a liver transplant during the period 2009–2012 at the J.P. Garrahan Pediatric Hospital. Tacrolimus levels from day five up to two years after the transplant were obtained from hospital records of routine therapeutic drug monitoring. The genotyping of CYP3A5 (CYP3A5*1/*3 or *3/*3) was performed in liver biopsies from both the donor and the recipient. The frequency of CYP3A5*1 expression for recipients was 37.1% and 32.2% for donors. Patients who received an expresser organ showed lower Co/dose, especially following 90 days after the surgery. The role of each polymorphism is di erent according to the number of days after the transplant, and it must be taken into account to optimize the benefits of TAC therapy during the post-transplant induction and maintenance phases. |
| publishDate |
2020 |
| dc.date.issued.none.fl_str_mv |
2020 |
| dc.date.accessioned.none.fl_str_mv |
2025-02-11T16:45:05Z |
| dc.date.available.none.fl_str_mv |
2025-02-11T16:45:05Z |
| dc.type.spa.fl_str_mv |
Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/ART |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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publishedVersion |
| dc.identifier.citation.spa.fl_str_mv |
Buendía JA, Halac E, Bosaleh A, Garcia de Davila MT, Imvertasa O, Bramuglia G. Frequency of CYP3A5 Genetic Polymorphisms and Tacrolimus Pharmacokinetics in Pediatric Liver Transplantation. Pharmaceutics. 2020 Sep 22;12(9):898. doi: 10.3390/pharmaceutics12090898. |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/10495/44827 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/pharmaceutics12090898 |
| dc.identifier.eissn.none.fl_str_mv |
1999-4923 |
| identifier_str_mv |
Buendía JA, Halac E, Bosaleh A, Garcia de Davila MT, Imvertasa O, Bramuglia G. Frequency of CYP3A5 Genetic Polymorphisms and Tacrolimus Pharmacokinetics in Pediatric Liver Transplantation. Pharmaceutics. 2020 Sep 22;12(9):898. doi: 10.3390/pharmaceutics12090898. 10.3390/pharmaceutics12090898 1999-4923 |
| url |
https://hdl.handle.net/10495/44827 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Pharmaceutics |
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7 |
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9 |
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1 |
| dc.relation.citationvolume.spa.fl_str_mv |
12 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Pharmaceutics |
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https://creativecommons.org/licenses/by/4.0/ |
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http://creativecommons.org/licenses/by/2.5/co/ |
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info:eu-repo/semantics/openAccess |
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http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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7 páginas |
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application/pdf |
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MDPI |
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Basilea, Suiza |
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Buendía Rodríguez, Jefferson AntonioHalac, EstebanBosaleh, AndreaGarcía de Dávila, María TeresaImvertasa, Óscar CésarBramuglia, Guillermo FedericoGrupo de Investigación en Farmacología y Toxicología2025-02-11T16:45:05Z2025-02-11T16:45:05Z2020Buendía JA, Halac E, Bosaleh A, Garcia de Davila MT, Imvertasa O, Bramuglia G. Frequency of CYP3A5 Genetic Polymorphisms and Tacrolimus Pharmacokinetics in Pediatric Liver Transplantation. Pharmaceutics. 2020 Sep 22;12(9):898. doi: 10.3390/pharmaceutics12090898.https://hdl.handle.net/10495/4482710.3390/pharmaceutics120908981999-4923ABSTRACT: The evidence available in the pediatric population is limited for making clinical decisions regarding the optimization of tacrolimus (TAC) in pharmacotherapy. The objective of this study was to estimate the frequency of CYP3A5 genetic polymorphisms and their relationship with tacrolimus requirements in the pediatric population. This was a longitudinal cohort study with a two-year follow-up of 77 patients under 18 years old who underwent a liver transplant during the period 2009–2012 at the J.P. Garrahan Pediatric Hospital. Tacrolimus levels from day five up to two years after the transplant were obtained from hospital records of routine therapeutic drug monitoring. The genotyping of CYP3A5 (CYP3A5*1/*3 or *3/*3) was performed in liver biopsies from both the donor and the recipient. The frequency of CYP3A5*1 expression for recipients was 37.1% and 32.2% for donors. Patients who received an expresser organ showed lower Co/dose, especially following 90 days after the surgery. The role of each polymorphism is di erent according to the number of days after the transplant, and it must be taken into account to optimize the benefits of TAC therapy during the post-transplant induction and maintenance phases.COL00399027 páginasapplication/pdfengMDPIBasilea, Suizahttps://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/2.5/co/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Frequency of CYP3A5 Genetic Polymorphisms and Tacrolimus Pharmacokinetics in Pediatric Liver TransplantationArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionTacrolimusTrasplante de HígadoLiver TransplantationFarmacocinéticaPharmacokineticsPolimorfismo GenéticoPolymorphism, GeneticCitocromo P-450 CYP3ACytochrome P-450 CYP3Ahttps://id.nlm.nih.gov/mesh/D016559https://id.nlm.nih.gov/mesh/D016031https://id.nlm.nih.gov/mesh/D010599https://id.nlm.nih.gov/mesh/D011110https://id.nlm.nih.gov/mesh/D051544Pharmaceutics79112PharmaceuticsPublicationORIGINALBuendiaJefferson_2020_Frequency_CYP3A5_Genetic_Polymorphisms.pdfBuendiaJefferson_2020_Frequency_CYP3A5_Genetic_Polymorphisms.pdfArtículo de investigaciónapplication/pdf563388https://bibliotecadigital.udea.edu.co/bitstreams/7d867fc1-ef22-48aa-9577-19da8e98c0e2/download19f9774e85fb771ce0a8ed62a8d8fbc9MD51trueAnonymousREADBuendiaJefferson_2020_Frequency_CYP3A5_Genetic_Polymorphisms.epubBuendiaJefferson_2020_Frequency_CYP3A5_Genetic_Polymorphisms.epubArtículo de investigaciónapplication/epub+zip122065https://bibliotecadigital.udea.edu.co/bitstreams/4a5d78b7-22a0-4ee5-b2ef-a2b66830704f/download8f38778902d06a1255b144f195232ea8MD54falseAnonymousREADCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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