Harmonized-Multinational qEEG norms (HarMNqEEG)

ABSTRACT: This paper extends frequency domain quantitative electroencephalography (qEEG) methods pursuing higher sensitivity to detect Brain Developmental Disorders. Prior qEEG work lacked integration of cross-spectral information omitting important functional connectivity descriptors. Lack of geographical diversity precluded accounting for site-specific variance, increasing qEEG nuisance variance. We ameliorate these weaknesses. (i) Create lifespan Riemannian multinational qEEG norms for cross-spectral tensors. These norms result from the HarMNqEEG project fostered by the Global Brain Consortium. We calculate the norms with data from 9 countries, 12 devices, and 14 studies, including 1564 subjects. Instead of raw data, only anonymized metadata and EEG cross-spectral tensors were shared. After visual and automatic quality control, developmental equations for the mean and standard deviation of qEEG traditional and Riemannian DPs were calculated using additive mixed-effects models. We demonstrate qEEG "batch effects" and provide methods to calculate harmonized z-scores. (ii) We also show that harmonized Riemannian norms produce z-scores with increased diagnostic accuracy predicting brain dysfunction produced by malnutrition in the first year of life and detecting COVID induced brain dysfunction. (iii) We offer open code and data to calculate different individual z-scores from the HarMNqEEG dataset. These results contribute to developing bias-free, low-cost neuroimaging technologies applicable in various health settings.

• Autores: Tobón Quintero, Carlos Andrés; Ochoa Gómez, John Fredy; Li, Min; Wang, Ying; López Naranjo, Carlos; Hu, Shiang; García Reyes, Ronaldo César; Paz Linares, Deirel; Areces González, Ariosky; Abd Hamid, Aini Ismafairus; Evans, Alan C.; Savostyanov, Alexander N.; Calzada Reyes, Ana; Villringer, Arno; García Agustín, Daysi; Yao, Dezhong; Dong, Li; Aubert Vázquez, Eduardo; Reza, Faruque; Razzaq, Fuleah Abdul; Omar, Hazim; Abdullah, Jafri Malin; Galler, Janina R.; Prichep, Leslie S.; Galán García, Lidice; Morales Chacón, Lilia; Valdés Sosa, Mitchell J.; Tröndle, Marius; Mohd Zulkifly, Mohd Faizal; Rahman, Muhammad Riddha Bin Abdul; Milakhina, Natalya S.; Langer, Nicolas; Rudych, Pavel; Koenig, Thomas; Virues Alba, Trinidad A.; Lei, Xu; Bringas Vega, Maria L.; Bosch Bayard, Jorge F.; Valdés Sosa, Pedro Antonio
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2022
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/42133
• Acceso en línea: https://hdl.handle.net/10495/42133
• Palabra clave: Éncefalo; Brain; Encefalopatías; Brain Diseases; Mapeo Encefálico; Brain Mapping; Electroencefalografía; Electroencephalography; COVID-19; https://id.nlm.nih.gov/mesh/D001921; https://id.nlm.nih.gov/mesh/D001927; https://id.nlm.nih.gov/mesh/D001931; https://id.nlm.nih.gov/mesh/D000086382; https://id.nlm.nih.gov/mesh/D004569
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc-nd/2.5/co/