Protein Kinase Inhibitors in Rheumatology
ABSTRACT: Protein kinases have multiple roles in cell biology, many of which are deeply involved in inflammation and immunity. There are currently many treatment options for patients with autoimmune disease, but none that is completely effective. Protein kinase inhibitors are becoming one of the mos...
- Autores:
-
Vásquez Duque, Gloria María
Herrera Uribe, Sebastián
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2014
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/34257
- Acceso en línea:
- https://hdl.handle.net/10495/34257
https://synergypublishers.com/downloads/jadrv2n1a4/
- Palabra clave:
- Lupus Erythematosus, Systemic
Lupus Eritematoso Sistémico
Protein Kinases
Proteínas Quinasas
Phosphotransferases
Fosfotransferasas
Janus Kinase 3
Janus Quinasa 3
Autoimmune Diseases
Enfermedades Autoinmunes
Rheumatology
Reumatología
Cyclin-Dependent Kinase Inhibitor Proteins
Proteínas Inhibidoras de las Quinasas Dependientes de la Ciclina
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by/4.0/
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Protein Kinase Inhibitors in Rheumatology |
| title |
Protein Kinase Inhibitors in Rheumatology |
| spellingShingle |
Protein Kinase Inhibitors in Rheumatology Lupus Erythematosus, Systemic Lupus Eritematoso Sistémico Protein Kinases Proteínas Quinasas Phosphotransferases Fosfotransferasas Janus Kinase 3 Janus Quinasa 3 Autoimmune Diseases Enfermedades Autoinmunes Rheumatology Reumatología Cyclin-Dependent Kinase Inhibitor Proteins Proteínas Inhibidoras de las Quinasas Dependientes de la Ciclina |
| title_short |
Protein Kinase Inhibitors in Rheumatology |
| title_full |
Protein Kinase Inhibitors in Rheumatology |
| title_fullStr |
Protein Kinase Inhibitors in Rheumatology |
| title_full_unstemmed |
Protein Kinase Inhibitors in Rheumatology |
| title_sort |
Protein Kinase Inhibitors in Rheumatology |
| dc.creator.fl_str_mv |
Vásquez Duque, Gloria María Herrera Uribe, Sebastián |
| dc.contributor.author.none.fl_str_mv |
Vásquez Duque, Gloria María Herrera Uribe, Sebastián |
| dc.contributor.researchgroup.spa.fl_str_mv |
Grupo de Reumatología Universidad de Antioquia -GRUA- |
| dc.subject.decs.none.fl_str_mv |
Lupus Erythematosus, Systemic Lupus Eritematoso Sistémico Protein Kinases Proteínas Quinasas Phosphotransferases Fosfotransferasas Janus Kinase 3 Janus Quinasa 3 Autoimmune Diseases Enfermedades Autoinmunes Rheumatology Reumatología Cyclin-Dependent Kinase Inhibitor Proteins Proteínas Inhibidoras de las Quinasas Dependientes de la Ciclina |
| topic |
Lupus Erythematosus, Systemic Lupus Eritematoso Sistémico Protein Kinases Proteínas Quinasas Phosphotransferases Fosfotransferasas Janus Kinase 3 Janus Quinasa 3 Autoimmune Diseases Enfermedades Autoinmunes Rheumatology Reumatología Cyclin-Dependent Kinase Inhibitor Proteins Proteínas Inhibidoras de las Quinasas Dependientes de la Ciclina |
| description |
ABSTRACT: Protein kinases have multiple roles in cell biology, many of which are deeply involved in inflammation and immunity. There are currently many treatment options for patients with autoimmune disease, but none that is completely effective. Protein kinase inhibitors are becoming one of the most promising therapeutic groups, not only for the treatment of disease, but for further developing our understanding of different pathologies. The purpose of this paper is to give an introduction to both protein kinases and their inhibitors, with their implications in the management of autoimmune diseases. |
| publishDate |
2014 |
| dc.date.issued.none.fl_str_mv |
2014 |
| dc.date.accessioned.none.fl_str_mv |
2023-03-27T19:49:45Z |
| dc.date.available.none.fl_str_mv |
2023-03-27T19:49:45Z |
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Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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1740-2557 |
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https://hdl.handle.net/10495/34257 |
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10.12970/2310-9874.2014.02.01.4 |
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1740-2557 10.12970/2310-9874.2014.02.01.4 |
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https://hdl.handle.net/10495/34257 https://synergypublishers.com/downloads/jadrv2n1a4/ |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
J. Autoimmune Dis. |
| dc.relation.citationendpage.spa.fl_str_mv |
27 |
| dc.relation.citationstartpage.spa.fl_str_mv |
13 |
| dc.relation.citationvolume.spa.fl_str_mv |
2 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Journal of Autoimmune Diseases |
| dc.rights.uri.spa.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
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http://creativecommons.org/licenses/by/2.5/co/ |
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BioMed Central |
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Londres, Inglaterra |
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sin facultad - programa |
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Vásquez Duque, Gloria MaríaHerrera Uribe, SebastiánGrupo de Reumatología Universidad de Antioquia -GRUA-2023-03-27T19:49:45Z2023-03-27T19:49:45Z20141740-2557https://hdl.handle.net/10495/3425710.12970/2310-9874.2014.02.01.4https://synergypublishers.com/downloads/jadrv2n1a4/ABSTRACT: Protein kinases have multiple roles in cell biology, many of which are deeply involved in inflammation and immunity. There are currently many treatment options for patients with autoimmune disease, but none that is completely effective. Protein kinase inhibitors are becoming one of the most promising therapeutic groups, not only for the treatment of disease, but for further developing our understanding of different pathologies. The purpose of this paper is to give an introduction to both protein kinases and their inhibitors, with their implications in the management of autoimmune diseases.COL001095915application/pdfengBioMed CentralLondres, Inglaterrasin facultad - programahttps://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/2.5/co/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Protein Kinase Inhibitors in RheumatologyArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/redcol/resource_type/CJournalArticlehttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionLupus Erythematosus, SystemicLupus Eritematoso SistémicoProtein KinasesProteínas QuinasasPhosphotransferasesFosfotransferasasJanus Kinase 3Janus Quinasa 3Autoimmune DiseasesEnfermedades AutoinmunesRheumatologyReumatologíaCyclin-Dependent Kinase Inhibitor ProteinsProteínas Inhibidoras de las Quinasas Dependientes de la CiclinaJ. Autoimmune Dis.27132Journal of Autoimmune DiseasesPublicationORIGINALVasquezGloria_2014_ProteinKinaseRheumatology.pdfVasquezGloria_2014_ProteinKinaseRheumatology.pdfArtículo de revistaapplication/pdf1404869https://bibliotecadigital.udea.edu.co/bitstreams/9cde150c-8ff8-4035-a8ec-8672bb161ec0/downloadae84dfa91467f6d3ca241474fa136b8aMD51trueAnonymousREADCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8927https://bibliotecadigital.udea.edu.co/bitstreams/3cf61db7-d726-4671-867f-d6c23c5aa3ce/download1646d1f6b96dbbbc38035efc9239ac9cMD52falseAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstreams/28b46252-ebf7-4720-9d78-d7875effb300/download8a4605be74aa9ea9d79846c1fba20a33MD53falseAnonymousREADTEXTVasquezGloria_2014_ProteinKinaseRheumatology.pdf.txtVasquezGloria_2014_ProteinKinaseRheumatology.pdf.txtExtracted texttext/plain79568https://bibliotecadigital.udea.edu.co/bitstreams/4e4c888d-937b-4eb0-bcb9-d01becf4760f/downloadb9fe4be0c62179c85980f78773819266MD54falseAnonymousREADTHUMBNAILVasquezGloria_2014_ProteinKinaseRheumatology.pdf.jpgVasquezGloria_2014_ProteinKinaseRheumatology.pdf.jpgGenerated Thumbnailimage/jpeg18255https://bibliotecadigital.udea.edu.co/bitstreams/ec3a3d2c-d202-48d0-a0e4-965553564372/download4ea5e720961905102d95cb2bbfc57f7fMD55falseAnonymousREAD10495/34257oai:bibliotecadigital.udea.edu.co:10495/342572025-03-26 20:05:00.27https://creativecommons.org/licenses/by/4.0/open.accesshttps://bibliotecadigital.udea.edu.coRepositorio Institucional de la Universidad de Antioquiaaplicacionbibliotecadigitalbiblioteca@udea.edu.coTk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo= |