Inmunopatogenia del pénfigo vulgar y el pénfigo foliáceo
ABSTRACT: Pemphigus vulgaris and pemphigus foliaceus are autoimmune blistering diseases mediated by antibodies against desmosomal proteins. They are strongly associated with major histocompatibility complex alleles with the ability to present antigenic peptides of desmogleins. In the affected indivi...
- Autores:
-
Valencia Ocampo, Oscar Jairo
Velásquez Lopera, Margarita María
- Tipo de recurso:
- Review article
- Fecha de publicación:
- 2011
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- spa
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/12969
- Acceso en línea:
- http://hdl.handle.net/10495/12969
- Palabra clave:
- Acantólisis
Fisiopatología
Inmunología
Pénfigo
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-sa/4.0/
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Inmunopatogenia del pénfigo vulgar y el pénfigo foliáceo |
| dc.title.translated.spa.fl_str_mv |
Immunopathogenesis of pemphigus vulgaris and pemphigus foliaceus |
| title |
Inmunopatogenia del pénfigo vulgar y el pénfigo foliáceo |
| spellingShingle |
Inmunopatogenia del pénfigo vulgar y el pénfigo foliáceo Acantólisis Fisiopatología Inmunología Pénfigo |
| title_short |
Inmunopatogenia del pénfigo vulgar y el pénfigo foliáceo |
| title_full |
Inmunopatogenia del pénfigo vulgar y el pénfigo foliáceo |
| title_fullStr |
Inmunopatogenia del pénfigo vulgar y el pénfigo foliáceo |
| title_full_unstemmed |
Inmunopatogenia del pénfigo vulgar y el pénfigo foliáceo |
| title_sort |
Inmunopatogenia del pénfigo vulgar y el pénfigo foliáceo |
| dc.creator.fl_str_mv |
Valencia Ocampo, Oscar Jairo Velásquez Lopera, Margarita María |
| dc.contributor.author.none.fl_str_mv |
Valencia Ocampo, Oscar Jairo Velásquez Lopera, Margarita María |
| dc.contributor.researchgroup.spa.fl_str_mv |
GRID - Grupo de Investigación Dermatológica |
| dc.subject.none.fl_str_mv |
Acantólisis Fisiopatología Inmunología Pénfigo |
| topic |
Acantólisis Fisiopatología Inmunología Pénfigo |
| description |
ABSTRACT: Pemphigus vulgaris and pemphigus foliaceus are autoimmune blistering diseases mediated by antibodies against desmosomal proteins. They are strongly associated with major histocompatibility complex alleles with the ability to present antigenic peptides of desmogleins. In the affected individuals the presence of auto-reactive T and B lymphocytes, and alterations in the immune system regulation with imbalance of the Th1/Th2 responses have been described. Damage mechanisms are not yet precisely known but current investigation indicates that antibodies play an important pathogenic role: they start different signaling cascades that lead to acantholysis and apoptosis of keratinocytes. Better knowledge of the pathogenesis of autoimmune blistering diseases has been the basis for the development and implementation of new therapeutic approaches. |
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2020-01-10T16:02:23Z |
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Valencia Ocampo OJ, Velásquez-Lopera MM. Inmunopatogenia del pénfigo vulgar y el pénfigo foliáceo. Iatreia. 2011 Sep-Nov;24(3):272-286. |
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0121-0793 |
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http://hdl.handle.net/10495/12969 |
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2011-7965 |
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Valencia Ocampo OJ, Velásquez-Lopera MM. Inmunopatogenia del pénfigo vulgar y el pénfigo foliáceo. Iatreia. 2011 Sep-Nov;24(3):272-286. 0121-0793 2011-7965 |
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Iatreia |
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Universidad de Antioquia, Facultad de Medicina |
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Valencia Ocampo, Oscar JairoVelásquez Lopera, Margarita MaríaGRID - Grupo de Investigación Dermatológica2020-01-10T16:02:23Z2020-01-10T16:02:23Z2011Valencia Ocampo OJ, Velásquez-Lopera MM. Inmunopatogenia del pénfigo vulgar y el pénfigo foliáceo. Iatreia. 2011 Sep-Nov;24(3):272-286.0121-0793http://hdl.handle.net/10495/129692011-7965ABSTRACT: Pemphigus vulgaris and pemphigus foliaceus are autoimmune blistering diseases mediated by antibodies against desmosomal proteins. They are strongly associated with major histocompatibility complex alleles with the ability to present antigenic peptides of desmogleins. In the affected individuals the presence of auto-reactive T and B lymphocytes, and alterations in the immune system regulation with imbalance of the Th1/Th2 responses have been described. Damage mechanisms are not yet precisely known but current investigation indicates that antibodies play an important pathogenic role: they start different signaling cascades that lead to acantholysis and apoptosis of keratinocytes. Better knowledge of the pathogenesis of autoimmune blistering diseases has been the basis for the development and implementation of new therapeutic approaches.RESUMEN: El pénfigo vulgar y el pénfigo foliáceo son enfermedades ampollosas autoinmunes mediadas por autoanticuerpos dirigidos contra proteínas de los desmosomas, las desmogleínas 1 y 3. Están asociadas con moléculas del complejo mayor de histocompatibilidad (HLA) que por su estructura tienen la capacidad de presentar péptidos antigénicos de las desmogleínas. En los individuos afectados se han descrito la presencia de linfocitos T y B autorreactivos y alteraciones en la regulación del sistema inmune con desequilibrio de las respuestas Th1/Th2. No se conocen con precisión los mecanismos de daño pero la investigación actual indica que los anticuerpos tienen un papel patogénico, inician diferentes cascadas de señalización que provocan la acantólisis y apoptosis de los queratinocitos. El conocimiento de la inmunopatogenia de las enfermedades ampollosas autoinmunes ha permitido el desarrollo y la puesta en práctica de nuevas alternativas terapéuticas.COL005083915 páginasapplication/pdfspaUniversidad de Antioquia, Facultad de MedicinaMedellín, Colombiahttps://creativecommons.org/licenses/by-nc-sa/4.0/https://creativecommons.org/licenses/by-nc-sa/2.5/co/Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2AcantólisisFisiopatologíaInmunologíaPénfigoInmunopatogenia del pénfigo vulgar y el pénfigo foliáceoImmunopathogenesis of pemphigus vulgaris and pemphigus foliaceusArtículo de revisiónhttp://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTREVhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionIatreia286324IatreiaPublicationORIGINALValenciaOscar_2011_InmunopatogeniaVulgarFoliaceo.pdfValenciaOscar_2011_InmunopatogeniaVulgarFoliaceo.pdfArtículo de revisiónapplication/pdf2184674https://bibliotecadigital.udea.edu.co/bitstreams/91c67665-052a-4adf-95c9-f75745b6a6de/download3b29303654091d43a310d6897f6de68bMD51trueAnonymousREADCC-LICENSElicense_urllicense_urltext/plain; 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