Accuracy of cotinine serum test to detect the smoking habit and its association with periodontal disease in a multicenter study

ABSTRACT: Background: The validity of the surveys on self-reported smoking status is often questioned because smokers underestimate cigarette use and deny the habit. It has been suggested that self-report should be accompanied by a cotinine test. This report evaluates the usefulness of serum cotinine test to assess the association between smoking and periodontal status in a study with a large sample population to be used in studies with other serum markers in epidemiologic and periodontal medicine research. Material and Methods: 578 patients who were part of a multicenter study on blood biomarkers were evaluated about smoking and its relation to periodontal disease. Severity of periodontal disease was determined using clinical attachment loss (CAL). Smoking was assessed by a questionnaire and a blood sample drawn for serum cotinine determination. Results: The optimal cut-off point for serum cotinine was 10 ng/ml. Serum cotinine showed greater association with severity of CAL than self-report for mild-moderate CAL [OR 2.03 (CI95% 1.16-3.53) vs. OR 1.08 (CI95%0.62-1.87) ] advanced periodontitis [OR 2.36 (CI95% 1.30- 4.31) vs. OR 2.06 (CI95% 0.97-4.38) ] and extension of CAL > 3 mm [ OR 1.78 (CI95% 1.16-1.71) vs. 1.37 (CI95% 0.89-2.11)]. When the two tests were evaluated together they were not shown to be better than serum cotinine tests. Conclusions: Self-reported smoking and serum cotinine test ≥ 10ng/ml are accurate,complementary and more reliable methods to assess the patient’s smoking status and could be used in studies evaluating serum samples in large population and multicenter studies. Clinical Relevance: The serum cotinine level is more reliable to make associations with the patient’s periodontal status than self-report questionnaire and could be used in multicenter and periodontal medicine studies.

• Autores: Ardila Medina, Carlos Martín; Duque Duque, Andrés; Gualtero Escobar, Diego Fernando; Martínez Carlier, Paula Juliana; Giraldo Aristizábal, Astrid
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2017
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/38779
• Acceso en línea: https://hdl.handle.net/10495/38779
• Palabra clave: Biomarcadores - sangre; Biomarkers - blood; Cotinina - sangre; Cotinine - blood; Enfermedades Periodontales; Periodontal Diseases; Fumar; Smoking; Periodontitis Agresiva; Aggressive Periodontitis; https://id.nlm.nih.gov/mesh/D015415; https://id.nlm.nih.gov/mesh/D003367; https://id.nlm.nih.gov/mesh/D010510; https://id.nlm.nih.gov/mesh/D012907; https://id.nlm.nih.gov/mesh/D010520
• Rights: openAccess
• License: https://creativecommons.org/licenses/by-nc-sa/4.0/