Monoamine and Iron-related Toxicity : From Serotonin-binding Proteins to Lipid Peroxidation and Apoptosis in PC12 Cells
ABSTRACT: 1. Monoamines do not form coordination bonds with a preformed iron–serotonin-binding protein (SBP) complex, as initially believed. Instead, metals oxidize the monoamines either directly (manganese, copper) or by oxygen free radical formation (iron), the oxidation products bind covalently t...
- Autores:
-
Vélez Pardo, Carlos Alberto
Jiménez del Río, Marlene
Ebinger, Guy
Vauquelin, Georges
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 1998
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/34000
- Acceso en línea:
- https://hdl.handle.net/10495/34000
https://www.sciencedirect.com/science/article/pii/S0306362397004400?via%3Dihub
- Palabra clave:
- Lipid Peroxidation
Peroxidación de Lípido
Apoptosis
Apoptosis
Monoamine Oxidase
Monoaminooxidasa
Iron
Hierro
PC12 Cells
Células PC12
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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| dc.title.spa.fl_str_mv |
Monoamine and Iron-related Toxicity : From Serotonin-binding Proteins to Lipid Peroxidation and Apoptosis in PC12 Cells |
| title |
Monoamine and Iron-related Toxicity : From Serotonin-binding Proteins to Lipid Peroxidation and Apoptosis in PC12 Cells |
| spellingShingle |
Monoamine and Iron-related Toxicity : From Serotonin-binding Proteins to Lipid Peroxidation and Apoptosis in PC12 Cells Lipid Peroxidation Peroxidación de Lípido Apoptosis Apoptosis Monoamine Oxidase Monoaminooxidasa Iron Hierro PC12 Cells Células PC12 |
| title_short |
Monoamine and Iron-related Toxicity : From Serotonin-binding Proteins to Lipid Peroxidation and Apoptosis in PC12 Cells |
| title_full |
Monoamine and Iron-related Toxicity : From Serotonin-binding Proteins to Lipid Peroxidation and Apoptosis in PC12 Cells |
| title_fullStr |
Monoamine and Iron-related Toxicity : From Serotonin-binding Proteins to Lipid Peroxidation and Apoptosis in PC12 Cells |
| title_full_unstemmed |
Monoamine and Iron-related Toxicity : From Serotonin-binding Proteins to Lipid Peroxidation and Apoptosis in PC12 Cells |
| title_sort |
Monoamine and Iron-related Toxicity : From Serotonin-binding Proteins to Lipid Peroxidation and Apoptosis in PC12 Cells |
| dc.creator.fl_str_mv |
Vélez Pardo, Carlos Alberto Jiménez del Río, Marlene Ebinger, Guy Vauquelin, Georges |
| dc.contributor.author.none.fl_str_mv |
Vélez Pardo, Carlos Alberto Jiménez del Río, Marlene Ebinger, Guy Vauquelin, Georges |
| dc.contributor.researchgroup.spa.fl_str_mv |
Grupo de Neurociencias de Antioquia |
| dc.subject.decs.none.fl_str_mv |
Lipid Peroxidation Peroxidación de Lípido Apoptosis Apoptosis Monoamine Oxidase Monoaminooxidasa Iron Hierro PC12 Cells Células PC12 |
| topic |
Lipid Peroxidation Peroxidación de Lípido Apoptosis Apoptosis Monoamine Oxidase Monoaminooxidasa Iron Hierro PC12 Cells Células PC12 |
| description |
ABSTRACT: 1. Monoamines do not form coordination bonds with a preformed iron–serotonin-binding protein (SBP) complex, as initially believed. Instead, metals oxidize the monoamines either directly (manganese, copper) or by oxygen free radical formation (iron), the oxidation products bind covalently to SBP and the conjugates are able to undergo redox cycling. These interactions are denoted as a “molecular oxidative mechanism.” 2. Dopamine in combination with iron induces lipid peroxidation and apoptosis in PC12 cells by a stress oxidative-Ca2+ independent mechanism. 3. Dopamine–iron cytotoxicity may have relevance to an understanding of the mechanism by which dopaminergic neurons are eroded in some neurodegenerative disorders. |
| publishDate |
1998 |
| dc.date.issued.none.fl_str_mv |
1998 |
| dc.date.accessioned.none.fl_str_mv |
2023-03-14T21:06:09Z |
| dc.date.available.none.fl_str_mv |
2023-03-14T21:06:09Z |
| dc.type.spa.fl_str_mv |
Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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https://purl.org/redcol/resource_type/ART |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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0306-3623 |
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https://hdl.handle.net/10495/34000 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/S0306-3623(97)00440-0 |
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https://www.sciencedirect.com/science/article/pii/S0306362397004400?via%3Dihub |
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0306-3623 10.1016/S0306-3623(97)00440-0 |
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| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Gen. Pharmacol. |
| dc.relation.citationendpage.spa.fl_str_mv |
24 |
| dc.relation.citationissue.spa.fl_str_mv |
1 |
| dc.relation.citationstartpage.spa.fl_str_mv |
19 |
| dc.relation.citationvolume.spa.fl_str_mv |
31 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
General Pharmacology: The Vascular System |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/2.5/co/ |
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Elsevier |
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Vélez Pardo, Carlos AlbertoJiménez del Río, MarleneEbinger, GuyVauquelin, GeorgesGrupo de Neurociencias de Antioquia2023-03-14T21:06:09Z2023-03-14T21:06:09Z19980306-3623https://hdl.handle.net/10495/3400010.1016/S0306-3623(97)00440-0https://www.sciencedirect.com/science/article/pii/S0306362397004400?via%3DihubABSTRACT: 1. Monoamines do not form coordination bonds with a preformed iron–serotonin-binding protein (SBP) complex, as initially believed. Instead, metals oxidize the monoamines either directly (manganese, copper) or by oxygen free radical formation (iron), the oxidation products bind covalently to SBP and the conjugates are able to undergo redox cycling. These interactions are denoted as a “molecular oxidative mechanism.” 2. Dopamine in combination with iron induces lipid peroxidation and apoptosis in PC12 cells by a stress oxidative-Ca2+ independent mechanism. 3. Dopamine–iron cytotoxicity may have relevance to an understanding of the mechanism by which dopaminergic neurons are eroded in some neurodegenerative disorders.COL00107446application/pdfengElsevierOxford, Inglaterrasin facultad - programahttp://creativecommons.org/licenses/by-nc-nd/2.5/co/https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Monoamine and Iron-related Toxicity : From Serotonin-binding Proteins to Lipid Peroxidation and Apoptosis in PC12 CellsArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionLipid PeroxidationPeroxidación de LípidoApoptosisApoptosisMonoamine OxidaseMonoaminooxidasaIronHierroPC12 CellsCélulas PC12Gen. 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