Monoamine and Iron-related Toxicity : From Serotonin-binding Proteins to Lipid Peroxidation and Apoptosis in PC12 Cells

ABSTRACT: 1. Monoamines do not form coordination bonds with a preformed iron–serotonin-binding protein (SBP) complex, as initially believed. Instead, metals oxidize the monoamines either directly (manganese, copper) or by oxygen free radical formation (iron), the oxidation products bind covalently to SBP and the conjugates are able to undergo redox cycling. These interactions are denoted as a “molecular oxidative mechanism.” 2. Dopamine in combination with iron induces lipid peroxidation and apoptosis in PC12 cells by a stress oxidative-Ca2+ independent mechanism. 3. Dopamine–iron cytotoxicity may have relevance to an understanding of the mechanism by which dopaminergic neurons are eroded in some neurodegenerative disorders.

• Autores: Vélez Pardo, Carlos Alberto; Jiménez del Río, Marlene; Ebinger, Guy; Vauquelin, Georges
• Tipo de recurso: Article of investigation
• Fecha de publicación: 1998
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/34000
• Acceso en línea: https://hdl.handle.net/10495/34000; https://www.sciencedirect.com/science/article/pii/S0306362397004400?via%3Dihub
• Palabra clave: Lipid Peroxidation; Peroxidación de Lípido; Apoptosis; Apoptosis; Monoamine Oxidase; Monoaminooxidasa; Iron; Hierro; PC12 Cells; Células PC12
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc-nd/2.5/co/