Distribution of APOE polymorphism in the ‘‘Paisa’’ population from northwest Colombia (Antioquia)
ABSTRACT: Background: The apolipoprotein E (APOE) gene plays a pivotal role in cholesterol metabolism. Since the discovery of the APOE*2 and APOE*4 as the major susceptibility alleles for several diseases including dyslipidemia, atherosclerosis, coronary heart disease, late-onset and early Alzheimer...
- Autores:
-
Vélez Pardo, Carlos Alberto
Jiménez del Río, Marlene
Bedoya Berrío, Gabriel de Jesús
Rojas Montoya, Winston
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2014
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/30936
- Acceso en línea:
- https://hdl.handle.net/10495/30936
- Palabra clave:
- Distancia genética
Genetic distance
Apolipoproteína
Apolipoproteins
Polimorfismo
Polymorphism
http://aims.fao.org/aos/agrovoc/c_36526
http://aims.fao.org/aos/agrovoc/c_6088
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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| dc.title.spa.fl_str_mv |
Distribution of APOE polymorphism in the ‘‘Paisa’’ population from northwest Colombia (Antioquia) |
| title |
Distribution of APOE polymorphism in the ‘‘Paisa’’ population from northwest Colombia (Antioquia) |
| spellingShingle |
Distribution of APOE polymorphism in the ‘‘Paisa’’ population from northwest Colombia (Antioquia) Distancia genética Genetic distance Apolipoproteína Apolipoproteins Polimorfismo Polymorphism http://aims.fao.org/aos/agrovoc/c_36526 http://aims.fao.org/aos/agrovoc/c_6088 |
| title_short |
Distribution of APOE polymorphism in the ‘‘Paisa’’ population from northwest Colombia (Antioquia) |
| title_full |
Distribution of APOE polymorphism in the ‘‘Paisa’’ population from northwest Colombia (Antioquia) |
| title_fullStr |
Distribution of APOE polymorphism in the ‘‘Paisa’’ population from northwest Colombia (Antioquia) |
| title_full_unstemmed |
Distribution of APOE polymorphism in the ‘‘Paisa’’ population from northwest Colombia (Antioquia) |
| title_sort |
Distribution of APOE polymorphism in the ‘‘Paisa’’ population from northwest Colombia (Antioquia) |
| dc.creator.fl_str_mv |
Vélez Pardo, Carlos Alberto Jiménez del Río, Marlene Bedoya Berrío, Gabriel de Jesús Rojas Montoya, Winston |
| dc.contributor.author.none.fl_str_mv |
Vélez Pardo, Carlos Alberto Jiménez del Río, Marlene Bedoya Berrío, Gabriel de Jesús Rojas Montoya, Winston |
| dc.contributor.researchgroup.spa.fl_str_mv |
Genética Molecular (GENMOL) Grupo de Neurociencias de Antioquia |
| dc.subject.lemb.none.fl_str_mv |
Distancia genética Genetic distance |
| topic |
Distancia genética Genetic distance Apolipoproteína Apolipoproteins Polimorfismo Polymorphism http://aims.fao.org/aos/agrovoc/c_36526 http://aims.fao.org/aos/agrovoc/c_6088 |
| dc.subject.agrovoc.none.fl_str_mv |
Apolipoproteína Apolipoproteins Polimorfismo Polymorphism |
| dc.subject.agrovocuri.none.fl_str_mv |
http://aims.fao.org/aos/agrovoc/c_36526 http://aims.fao.org/aos/agrovoc/c_6088 |
| description |
ABSTRACT: Background: The apolipoprotein E (APOE) gene plays a pivotal role in cholesterol metabolism. Since the discovery of the APOE*2 and APOE*4 as the major susceptibility alleles for several diseases including dyslipidemia, atherosclerosis, coronary heart disease, late-onset and early Alzheimer’s disease, the APOE genotype might be considered as a potential predictive factor for both epidemiological research and diagnosis. Aim: The aim of this study is to report on the polymorphism of the APOE gene in the ‘‘Paisa’’ population from northwest Colombia (Antioquia) to obtain a population baseline of the existing variation in this locus. Method: One thousand and one healthy voluntaries were genotyped for the APOE polymorphism using polymerase chain reaction–restriction fragment length polymorphism technique. Results: The APOE*3/*3 genotype presented the highest frequency (66.33%) and the APOE*4/*4 had the lowest frequency (1.89%). Genotype frequencies comply with Hardy–Weinberg expectations. Allele frequencies obtained for APOE*2, APOE*3 and APOE*4 were 0.075 ± 0.005 (95% CI ¼ 0.063–0.086), 0.814 ± 0.009 (0.797–0.831) and 0.111 ± 0.007 (0.098–0.125), respectively. Conclusion: Although globally the high-to-low APOE frequency follows the E*34E*44E*2 trend, the present APOE frequency data is in disagreement with some reports from SouthAmerican countries. |
| publishDate |
2014 |
| dc.date.issued.none.fl_str_mv |
2014 |
| dc.date.accessioned.none.fl_str_mv |
2022-09-27T22:22:29Z |
| dc.date.available.none.fl_str_mv |
2022-09-27T22:22:29Z |
| dc.type.spa.fl_str_mv |
Artículo de investigación |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
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https://purl.org/redcol/resource_type/ART |
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info:eu-repo/semantics/article |
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info:eu-repo/semantics/acceptedVersion |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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acceptedVersion |
| dc.identifier.citation.spa.fl_str_mv |
Vélez-Pardo, Carlos & Rojas, Winston & Rio, Marlene & Bedoya, Gabriel. (2014). Distribution of APOE polymorphism in the "Paisa'' population from northwest Colombia (Antioquia). Annals of human biology. 42. 1-4. 10.3109/03014460.2014.932846. |
| dc.identifier.issn.none.fl_str_mv |
0301-4460 |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/10495/30936 |
| dc.identifier.doi.none.fl_str_mv |
10.3109/03014460.2014.932846 |
| dc.identifier.eissn.none.fl_str_mv |
1464-5033 |
| identifier_str_mv |
Vélez-Pardo, Carlos & Rojas, Winston & Rio, Marlene & Bedoya, Gabriel. (2014). Distribution of APOE polymorphism in the "Paisa'' population from northwest Colombia (Antioquia). Annals of human biology. 42. 1-4. 10.3109/03014460.2014.932846. 0301-4460 10.3109/03014460.2014.932846 1464-5033 |
| url |
https://hdl.handle.net/10495/30936 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Ann. Hum. Biol. |
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4 |
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2 |
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1 |
| dc.relation.citationvolume.spa.fl_str_mv |
42 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Annals of Human Biology |
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http://creativecommons.org/licenses/by-nc-nd/2.5/co/ |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/2.5/co/ https://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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4 |
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application/pdf |
| dc.publisher.spa.fl_str_mv |
Society for the Study of Human Biology (SSHB) Taylor & Francis |
| dc.publisher.place.spa.fl_str_mv |
Londres, Inglaterra |
| institution |
Universidad de Antioquia |
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Vélez Pardo, Carlos AlbertoJiménez del Río, MarleneBedoya Berrío, Gabriel de JesúsRojas Montoya, WinstonGenética Molecular (GENMOL)Grupo de Neurociencias de Antioquia2022-09-27T22:22:29Z2022-09-27T22:22:29Z2014Vélez-Pardo, Carlos & Rojas, Winston & Rio, Marlene & Bedoya, Gabriel. (2014). Distribution of APOE polymorphism in the "Paisa'' population from northwest Colombia (Antioquia). Annals of human biology. 42. 1-4. 10.3109/03014460.2014.932846.0301-4460https://hdl.handle.net/10495/3093610.3109/03014460.2014.9328461464-5033ABSTRACT: Background: The apolipoprotein E (APOE) gene plays a pivotal role in cholesterol metabolism. Since the discovery of the APOE*2 and APOE*4 as the major susceptibility alleles for several diseases including dyslipidemia, atherosclerosis, coronary heart disease, late-onset and early Alzheimer’s disease, the APOE genotype might be considered as a potential predictive factor for both epidemiological research and diagnosis. Aim: The aim of this study is to report on the polymorphism of the APOE gene in the ‘‘Paisa’’ population from northwest Colombia (Antioquia) to obtain a population baseline of the existing variation in this locus. Method: One thousand and one healthy voluntaries were genotyped for the APOE polymorphism using polymerase chain reaction–restriction fragment length polymorphism technique. Results: The APOE*3/*3 genotype presented the highest frequency (66.33%) and the APOE*4/*4 had the lowest frequency (1.89%). Genotype frequencies comply with Hardy–Weinberg expectations. Allele frequencies obtained for APOE*2, APOE*3 and APOE*4 were 0.075 ± 0.005 (95% CI ¼ 0.063–0.086), 0.814 ± 0.009 (0.797–0.831) and 0.111 ± 0.007 (0.098–0.125), respectively. Conclusion: Although globally the high-to-low APOE frequency follows the E*34E*44E*2 trend, the present APOE frequency data is in disagreement with some reports from SouthAmerican countries.Colombia. Ministerio de Ciencia, Tecnología e InnovaciónCOL0006723COL00107444application/pdfengSociety for the Study of Human Biology (SSHB)Taylor & FrancisLondres, Inglaterrahttp://creativecommons.org/licenses/by-nc-nd/2.5/co/https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Distribution of APOE polymorphism in the ‘‘Paisa’’ population from northwest Colombia (Antioquia)Artículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionDistancia genéticaGenetic distanceApolipoproteínaApolipoproteinsPolimorfismoPolymorphismhttp://aims.fao.org/aos/agrovoc/c_36526http://aims.fao.org/aos/agrovoc/c_6088Ann. Hum. 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