Furan type lignans with antimycobacterial activity

ABSTRACT: Compounds such as triclosan, diclofenac and trimetropin posses antibacterial activity, including mycobacterial; their structures are based on two aromatic rings joined by a methylene or a heteroatom. Since a similar structural system is found in natural diarylfuranbased lignans, we studied plants known with this type of lignans, as potential active against Mycobacterium tuberculosis. Fractions of the active extracts were tested for anti-TB activity and their chemical constituents analyzed by NMR spectroscopy. Several extracts and chromatographical fractions exhibited > 90% inhibition of M. tuberculosis at 128 ug/mL. Methylpluviatilol, a pure compound isolated from Virola sebifera, was active at this concentration. These findings suggest that plant species of the families here studied may yield novel lead compounds for the development of antimycobacterial agents.

• Autores: Baquero Salazar, Eduard; Quiñones Fletcher, Winston; Franzblau, Scott; Torres, Fernando; Archbold Joseph, Rosendo; Echeverri López, Luis Fernando
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2015
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/22184
• Acceso en línea: http://hdl.handle.net/10495/22184
• Palabra clave: Lignanos; Lignans; Antibacterianos; Anti-Bacterial Agents; Tuberculosis; Ensayo biológico; Bio-assays; Arilfurano; http://aims.fao.org/aos/agrovoc/c_7997; http://aims.fao.org/aos/agrovoc/c_15731; https://id.nlm.nih.gov/mesh/D017705; https://id.nlm.nih.gov/mesh/D000900
• Rights: openAccess
• License: https://creativecommons.org/licenses/by-nc-nd/4.0/