Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: comparison with two commercial antivenoms

ABSTRACT: Three horse-derived antivenoms were tested for their ability to neu-tralize lethal, hemorrhagic, edema-forming, defibrinating and myotoxicactivitiesinduced by the venom of Bothrops atrox from Antioquia andChocó (Colombia). The following antivenoms were used: a) polyva-lent (crotaline) antivenom produced by Instituto Clodomiro Picado(Costa Rica), b) monovalent antibothropic antivenom produced byInstituto Nacional de Salud-INS (Bogotá), and c) a new monovalentanti-B. atrox antivenom produced with the venom of B. atrox fromAntioquia and Chocó. The three antivenoms neutralized alltoxicactivitiestested albeit with different potencies. The new monovalentanti-B. atrox antivenomshowed the highest neutralizing ability againstedema-forming and defibrinating effects of B. atrox venom (41 ± 2and 100 ± 32 μl antivenom/mgvenom, respectively), suggesting thatitshould be usefulin the treatment of B. atrox envenomation inAntioquia and Chocó.

• Autores: Valle Agudelo, Gustavo del; Estrada, Ricardo; Valderrama Hernández, Rafael; Robles, Abel; Osorio Gutiérrez, Raúl Guillermo; Gutiérrez Gutiérrez, José María; Otero Patiño, Rafael; Giraldo, César Augusto; Núñez Rangel, Vitelbina
• Tipo de recurso: Article of investigation
• Fecha de publicación: 1997
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/25225
• Acceso en línea: http://hdl.handle.net/10495/25225
• Palabra clave: Bothrops; Venenos de Serpiente; Snake Venoms; Neutralización; Neutralization; Antioquia (Colombia); Chocó (Colombia)
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc-sa/2.5/co/