Formulation of a modified release metformin.HCl matrix tablets : influence of some hydrophilic polymers on the release rate and in-vitro evaluation
ABSTRACT: Metformin hydrochloride is an antidiabetic agent which improves glucose tolerance in patients with type 2 diabetes and reduces basal plasma levels of glucose. In this study, a simplex centroid experimental design with 69 runs was used to select the best combination of some hydrophilic poly...
- Autores:
-
Rojas Camargo, John Jairo
González, César
Sáenz, Oswaldo
Ricco, Carolina
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2011
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/25227
- Acceso en línea:
- http://hdl.handle.net/10495/25227
- Palabra clave:
- Metformina
Metformin
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-sa/2.5/co/
| id |
UDEA2_3363aa08e6ac32580996cc5a0a89a487 |
|---|---|
| oai_identifier_str |
oai:bibliotecadigital.udea.edu.co:10495/25227 |
| network_acronym_str |
UDEA2 |
| network_name_str |
Repositorio UdeA |
| repository_id_str |
|
| dc.title.spa.fl_str_mv |
Formulation of a modified release metformin.HCl matrix tablets : influence of some hydrophilic polymers on the release rate and in-vitro evaluation |
| title |
Formulation of a modified release metformin.HCl matrix tablets : influence of some hydrophilic polymers on the release rate and in-vitro evaluation |
| spellingShingle |
Formulation of a modified release metformin.HCl matrix tablets : influence of some hydrophilic polymers on the release rate and in-vitro evaluation Metformina Metformin |
| title_short |
Formulation of a modified release metformin.HCl matrix tablets : influence of some hydrophilic polymers on the release rate and in-vitro evaluation |
| title_full |
Formulation of a modified release metformin.HCl matrix tablets : influence of some hydrophilic polymers on the release rate and in-vitro evaluation |
| title_fullStr |
Formulation of a modified release metformin.HCl matrix tablets : influence of some hydrophilic polymers on the release rate and in-vitro evaluation |
| title_full_unstemmed |
Formulation of a modified release metformin.HCl matrix tablets : influence of some hydrophilic polymers on the release rate and in-vitro evaluation |
| title_sort |
Formulation of a modified release metformin.HCl matrix tablets : influence of some hydrophilic polymers on the release rate and in-vitro evaluation |
| dc.creator.fl_str_mv |
Rojas Camargo, John Jairo González, César Sáenz, Oswaldo Ricco, Carolina |
| dc.contributor.author.none.fl_str_mv |
Rojas Camargo, John Jairo González, César Sáenz, Oswaldo Ricco, Carolina |
| dc.contributor.researchgroup.spa.fl_str_mv |
Diseño y Formulación de Medicamentos Cosméticos y Afines |
| dc.subject.decs.none.fl_str_mv |
Metformina Metformin |
| topic |
Metformina Metformin |
| description |
ABSTRACT: Metformin hydrochloride is an antidiabetic agent which improves glucose tolerance in patients with type 2 diabetes and reduces basal plasma levels of glucose. In this study, a simplex centroid experimental design with 69 runs was used to select the best combination of some hydrophilic polymers that rendered a 24 h in-vitro release profile of metformin.HCl. The Korsmeyer-Peppas model was used to model the dissolution profiles since it presented the best fit to the experimental data. Further, a cubic model predicted the best formulation of metformin.HCl containing polyvinyl pyrrolidone, ethyl cellulose, hydroxypropyl methyl cellulose, carrageenan, sodium alginate, and gum arabic at 6.26, 68.7, 6.26, 6.26, 6.26 and 6.26 % levels, respectively. The validation runs confirmed the accuracy of the cubic model with six components for predicting the best set of components which rendered a once-a-day modified release hydrophilic matrix tablet in compliance with the USP specifications. |
| publishDate |
2011 |
| dc.date.issued.none.fl_str_mv |
2011 |
| dc.date.accessioned.none.fl_str_mv |
2022-01-12T17:08:44Z |
| dc.date.available.none.fl_str_mv |
2022-01-12T17:08:44Z |
| dc.type.spa.fl_str_mv |
Artículo de investigación |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/ART |
| dc.type.coarversion.spa.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| status_str |
publishedVersion |
| dc.identifier.citation.spa.fl_str_mv |
Rojas J, González C, Rico C, Saez O. Formulation of a modified release metformin. HCl matrix tablet: influence of some hydrophilic polymers on release rate and in-vitro evaluation . Braz. J. Pharm. Sci. [Internet]. 2011Sep.1 [cited 2022Jan.12];47(3):483-9. Available from: https://www.revistas.usp.br/bjps/article/view/10909 |
| dc.identifier.issn.none.fl_str_mv |
1984-8250 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/25227 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/S1984-82502011000300006 |
| dc.identifier.eissn.none.fl_str_mv |
2175-9790 |
| identifier_str_mv |
Rojas J, González C, Rico C, Saez O. Formulation of a modified release metformin. HCl matrix tablet: influence of some hydrophilic polymers on release rate and in-vitro evaluation . Braz. J. Pharm. Sci. [Internet]. 2011Sep.1 [cited 2022Jan.12];47(3):483-9. Available from: https://www.revistas.usp.br/bjps/article/view/10909 1984-8250 10.1590/S1984-82502011000300006 2175-9790 |
| url |
http://hdl.handle.net/10495/25227 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Braz. J. Pharm. Sci. |
| dc.relation.citationendpage.spa.fl_str_mv |
493 |
| dc.relation.citationissue.spa.fl_str_mv |
3 |
| dc.relation.citationstartpage.spa.fl_str_mv |
483 |
| dc.relation.citationvolume.spa.fl_str_mv |
47 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc-sa/2.5/co/ |
| dc.rights.uri.spa.fl_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.coar.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-sa/2.5/co/ https://creativecommons.org/licenses/by-nc-sa/4.0/ http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.extent.spa.fl_str_mv |
11 |
| dc.format.mimetype.spa.fl_str_mv |
application/pdf |
| dc.publisher.spa.fl_str_mv |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas |
| dc.publisher.place.spa.fl_str_mv |
Sao Paulo, Brasil |
| institution |
Universidad de Antioquia |
| bitstream.url.fl_str_mv |
https://bibliotecadigital.udea.edu.co/bitstreams/71b38593-b557-4bff-bdfe-f828dd5349fd/download https://bibliotecadigital.udea.edu.co/bitstreams/4ff91d52-698f-4fee-bee4-3817f0e1b15a/download https://bibliotecadigital.udea.edu.co/bitstreams/7a111cf5-d466-41b1-a813-98559810c9d3/download https://bibliotecadigital.udea.edu.co/bitstreams/80ba0b58-d028-4af0-8047-8eda1d11b2fc/download https://bibliotecadigital.udea.edu.co/bitstreams/7e029dc5-4a6a-47fb-908e-a4e895aa34d7/download |
| bitstream.checksum.fl_str_mv |
0e767192815537eda296e1cbd4ad1a49 e2060682c9c70d4d30c83c51448f4eed 8a4605be74aa9ea9d79846c1fba20a33 ba259f62be8594d60962587aa504a5dc e9fe949263171c3f264223d916378578 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositorio Institucional de la Universidad de Antioquia |
| repository.mail.fl_str_mv |
aplicacionbibliotecadigitalbiblioteca@udea.edu.co |
| _version_ |
1851052472020238336 |
| spelling |
Rojas Camargo, John JairoGonzález, CésarSáenz, OswaldoRicco, CarolinaDiseño y Formulación de Medicamentos Cosméticos y Afines2022-01-12T17:08:44Z2022-01-12T17:08:44Z2011Rojas J, González C, Rico C, Saez O. Formulation of a modified release metformin. HCl matrix tablet: influence of some hydrophilic polymers on release rate and in-vitro evaluation . Braz. J. Pharm. Sci. [Internet]. 2011Sep.1 [cited 2022Jan.12];47(3):483-9. Available from: https://www.revistas.usp.br/bjps/article/view/109091984-8250http://hdl.handle.net/10495/2522710.1590/S1984-825020110003000062175-9790ABSTRACT: Metformin hydrochloride is an antidiabetic agent which improves glucose tolerance in patients with type 2 diabetes and reduces basal plasma levels of glucose. In this study, a simplex centroid experimental design with 69 runs was used to select the best combination of some hydrophilic polymers that rendered a 24 h in-vitro release profile of metformin.HCl. The Korsmeyer-Peppas model was used to model the dissolution profiles since it presented the best fit to the experimental data. Further, a cubic model predicted the best formulation of metformin.HCl containing polyvinyl pyrrolidone, ethyl cellulose, hydroxypropyl methyl cellulose, carrageenan, sodium alginate, and gum arabic at 6.26, 68.7, 6.26, 6.26, 6.26 and 6.26 % levels, respectively. The validation runs confirmed the accuracy of the cubic model with six components for predicting the best set of components which rendered a once-a-day modified release hydrophilic matrix tablet in compliance with the USP specifications.RESUMO: Metformina clorhidrato es un antidiabético agente cual mejora glucosa tolerancia en pacientes con escribe 2 diabetes y reduce basal plasma niveles de glucosa. En esta estudio, a simplex centroide experimental diseño con 69 carreras era usado para seleccionar el mejor combinación de algo hidrofílico polímeros que prestados a 24 h en vitrinao perfil de liberación de metformina.HCl. El modelo de Korsmeyer-Peppas se utilizó para modelar eldissolución perfiles ya que eso presentado el mejor t a el experimentantal datos. Más, a cubiC modelo predicted el mejor formulación de metformina.HCl conteniendo polivinilo pirrolidonami, etilo celulosa, hidroxipropilo metilo celulosa, carragenina, sodio alginato y goma Arábica en 6,26, 68,7, 6,26, 6,26, 6.26 y 6.26 % niveles, respectivamente. El validación corre confrmado el exactitud de El cúbico modelo con seis componentes por prediciendo el mejor colocar de componentes cual prestados a una vez al día modicado liberar hidrofílico tableta matricial de conformidad con la USP especifcaciones.COL000362311application/pdfengUniversidade de São Paulo, Faculdade de Ciências FarmacêuticasSao Paulo, Brasilhttp://creativecommons.org/licenses/by-nc-sa/2.5/co/https://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Formulation of a modified release metformin.HCl matrix tablets : influence of some hydrophilic polymers on the release rate and in-vitro evaluationArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionMetforminaMetforminBraz. J. Pharm. Sci.493348347Brazilian Journal of Pharmaceutical SciencesPublicationORIGINALRojasJuan_2011_FormulationModifiedRelease.pdfRojasJuan_2011_FormulationModifiedRelease.pdfArtículo de investigaciónapplication/pdf1845456https://bibliotecadigital.udea.edu.co/bitstreams/71b38593-b557-4bff-bdfe-f828dd5349fd/download0e767192815537eda296e1cbd4ad1a49MD51trueAnonymousREADCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81051https://bibliotecadigital.udea.edu.co/bitstreams/4ff91d52-698f-4fee-bee4-3817f0e1b15a/downloade2060682c9c70d4d30c83c51448f4eedMD52falseAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstreams/7a111cf5-d466-41b1-a813-98559810c9d3/download8a4605be74aa9ea9d79846c1fba20a33MD53falseAnonymousREADTEXTRojasJuan_2011_FormulationModifiedRelease.pdf.txtRojasJuan_2011_FormulationModifiedRelease.pdf.txtExtracted texttext/plain39074https://bibliotecadigital.udea.edu.co/bitstreams/80ba0b58-d028-4af0-8047-8eda1d11b2fc/downloadba259f62be8594d60962587aa504a5dcMD54falseAnonymousREADTHUMBNAILRojasJuan_2011_FormulationModifiedRelease.pdf.jpgRojasJuan_2011_FormulationModifiedRelease.pdf.jpgGenerated Thumbnailimage/jpeg14439https://bibliotecadigital.udea.edu.co/bitstreams/7e029dc5-4a6a-47fb-908e-a4e895aa34d7/downloade9fe949263171c3f264223d916378578MD55falseAnonymousREAD10495/25227oai:bibliotecadigital.udea.edu.co:10495/252272025-03-26 22:52:26.135http://creativecommons.org/licenses/by-nc-sa/2.5/co/open.accesshttps://bibliotecadigital.udea.edu.coRepositorio Institucional de la Universidad de Antioquiaaplicacionbibliotecadigitalbiblioteca@udea.edu.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 |