Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium

ABSTRACT: Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, with MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case-control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case-control status. Subtle case-control differences of brain macrostructural asymmetry may reflect differences at the molecular, cytoarchitectonic, or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia.

• Autores: Díaz Zuluaga, Ana María; López Jaramillo, Carlos Alberto; Pineda Zapata, Julian Alberto; Schijven, Dick; Postema, Merel C.; Fukunaga, Masaki; Matsumoto, Junya; Miura, Kenichiro; de Zwarte, Sonja M C.; van Haren, Neeltje E. M.; Cahn, Wiepke; Hulshoff Pol, Hilleke E.; Kahn, René S.; Ayesa Arriola, Rosa; Ortiz García de la Foz, Víctor; Tordesillas Gutiérrez, Diana; Vázquez Bourgon, Javier; Crespo Facorro, Benedicto; Alnæs, Dag; Dahl, Andreas; Westlye, Lars T.; Agartz, Ingrid; Andreassen, Ole A.; Jönsson, Erik G.; Bruggemann, Jason M.; Kochunov, Peter; Catts, Stanley V.; Michie, Patricia T.; Mowry, Bryan J.; Quidé, Yann; Rasser, Paul E.; Schall, Ulrich; Scott, Rodney J.; Carr, Vaughan J.; Green, Melissa J.; Henskens, Frans A.; Loughland, Carmel M.; Pantelis, Christos; Weickert, Cynthia Shannon; Weickert, Thomas W.; de Haan, Lieuwe; Brosch, Katharina; Pfarr, Julia-Katharina; Ringwald, Kai G.; Stein, Frederike; Jansen, Andreas; Kircher, Tilo T. J.; Nenadić, Igor; Krämer, Bernd; Gruber, Oliver; Satterthwaite, Theodore D.; Bustillo, Juan; Mathalon, Daniel H.; Preda, Adrian; Calhoun, Vince D.; Ford, Judith M.; Potkin, Steven G.; Chen, Jingxu; Tan, Yunlong; Wang, Zhiren; Xiang, Hong; Fan, Fengmei; Bernardoni, Fabio; Ehrlich, Stefan; Fuentes-Claramonte, Paola; García León, María Ángeles; Guerrero Pedraza, Amalia; Salvador, Raymond; Sarró, Salvador; Pomarol Clotet, Edith; Ciullo, Valentina; Piras, Fabrizio; Vecchio, Daniela; Banaj, Nerisa; Spalletta, Gianfranco; Michielse, Stijn; van Amelsvoort, Therese; Dickie, Erin W.; Voineskos, Aristotle N.; Sim, Kang; Ciufolini, Simone; Dazzan, Paola; Murray, Robin M; Kim, Woo Sung; Chung, Young Chul; Andreou, Christina; Schmidt, André; Borgwardt, Stefan; McIntosh, Andrew M.; Whalley, Heather C.; Lawrie, Stephen M.; du Plessis, Stefan; Luckhoff, Hilmar K.; Scheffler, Freda; Emsley, Robin; Grotegerd, Dominik; Lencer, Rebekka; Dannlowski, Udo; Edmond, Jesse T.; Rootes Murdy, Kelly; Stephen, Julia M.; Mayer, Andrew R.; Antonucci, Linda A.; Fazio, Leonardo; Pergola, Giulio; Bertolino, Alessandro; Janssen, Joost; Díaz Caneja, Covadonga M.; Lois, Noemi G.; Arango, Celso; Tomyshev, Alexander S.; Lebedeva, Irina; Cervenka, Simon; Sellgren, Carl M.; Georgiadis, Foivos; Kirschner, Matthias; Kaiser, Stefan; Hajek, Tomas; Skoch, Antonin; Spaniel, Filip; Kim, Minah; Kwak, Yoo Bin; Oh, Sanghoon; Kwon, Jun Soo; James, Anthony; Bakker, Geor; Knöchel, Christian; Stäblein, Michael; Oertel, Viola; Uhlmann, Anne; Howells, Fleur M.; Stein, Dan J.; Temmingh, Henk S.; Homan, Stephanie; Ji, Ellen; Surbeck, Werner; Homan, Philipp; Fisher, Simon E.; Franke, Barbara; Glahn, David C.; Gur, Ruben C.; Hashimoto, Ryota; Jahanshad, Neda; Luders, Eileen; Medland, Sarah E.; Thompson, Paul M.; Turner, Jessica A.; van Erp, Theo G. M.; Francks, Clyde
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2023
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/42112
• Acceso en línea: https://hdl.handle.net/10495/42112
• Palabra clave: Brain; Encéfalo; Case-Control Studies; Estudios de Casos y Controles; Cerebral Cortex; Corteza Cerebral; Functional Laterality; Lateralidad Funcional; Magnetic Resonance Imaging; Imagen por Resonancia Magnética; Schizophrenia; Esquizofrenia; https://id.nlm.nih.gov/mesh/D001921; https://id.nlm.nih.gov/mesh/D016022; https://id.nlm.nih.gov/mesh/D002540; https://id.nlm.nih.gov/mesh/D007839; https://id.nlm.nih.gov/mesh/D008279; https://id.nlm.nih.gov/mesh/D012559
• Rights: openAccess
• License: https://creativecommons.org/licenses/by/4.0/